scholarly journals C. elegans sym-1is a downstream target of the Hunchback-like-1 developmental timing transcription factor

Cell Cycle ◽  
2009 ◽  
Vol 8 (24) ◽  
pp. 4147-4154 ◽  
Author(s):  
Ryusuke Niwa ◽  
Kazumasa Hada ◽  
Kouichi Moliyama ◽  
Ryosuke L. Ohniwa ◽  
Yi-Meng Tan ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Developmental Timing ◽  
C Elegans ◽  
Downstream Target

scholarly journals The temporally regulated transcription factor SEL-7 controls developmental timing in C. elegans

2009 ◽  
Vol 332 (2) ◽  
pp. 246-257 ◽  
Author(s):  
Dan Xia ◽  
Xinxin Huang ◽  
Hong Zhang
Keyword(s):  
Transcription Factor ◽  
Developmental Timing ◽  
C Elegans

The Regulation of Downstream Target Gene AP-2γ by Transcription Factor OCT-4

2013 ◽  
Vol 40 (1) ◽  
pp. 43
Author(s):  
Xiao-Meng ZHAO ◽  
Cheng WANG ◽  
Xiao-Feng LI ◽  
Xiao-Ting ZHANG ◽  
Xi-Zhi LIU ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Target Gene ◽  
Downstream Target ◽  
Downstream Target Gene

scholarly journals Specific collagens maintain the cuticle permeability barrier in Caenorhabditis elegans

Genetics ◽  
2021 ◽  
Author(s):  
Anjali Sandhu ◽  
Divakar Badal ◽  
Riya Sheokand ◽  
Shalini Tyagi ◽  
Varsha Singh
Keyword(s):  
Transcription Factor ◽  
Caenorhabditis Elegans ◽  
Barrier Function ◽  
Permeability Barrier ◽  
Nematode Caenorhabditis Elegans ◽  
Zinc Finger Transcription Factor ◽  
Outermost Layer ◽  
C Elegans ◽  
Receptor Mutant ◽  
Antioxidant Machinery

Abstract Collagen enriched cuticle forms the outermost layer of skin in nematode Caenorhabditis elegans. The nematode’s genome encodes 177 collagens, but little is known about their role in maintaining the structure or barrier function of the cuticle. In this study, we found six permeability determining (PD) collagens. Loss of any of these PD collagens- DPY-2, DPY-3, DPY-7, DPY-8, DPY-9, and DPY-10- led to enhanced susceptibility of nematodes to paraquat (PQ) and antihelminthic drugs levamisole and ivermectin. Upon exposure to paraquat, PD collagen mutants accumulated more PQ and incurred more damage and death despite the robust activation of antioxidant machinery. We find that BLMP-1, a zinc finger transcription factor, maintains the barrier function of the cuticle by regulating the expression of PD collagens. We show that the permeability barrier maintained by PD collagens acts in parallel to FOXO transcription factor DAF-16 to enhance survival of insulin-like receptor mutant, daf-2. In all, this study shows that PD collagens regulate cuticle permeability by maintaining the structure of C. elegans cuticle and thus provide protection against exogenous toxins.

scholarly journals Regulatory Mutations of mir-48, a C. elegans let-7 Family MicroRNA, Cause Developmental Timing Defects

2005 ◽  
Vol 9 (3) ◽  
pp. 415-422 ◽  
Author(s):  
Ming Li ◽  
Matthew W. Jones-Rhoades ◽  
Nelson C. Lau ◽  
David P. Bartel ◽  
Ann E. Rougvie
Keyword(s):  
Developmental Timing ◽  
C Elegans ◽  
Regulatory Mutations ◽  
Timing Defects
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