scholarly journals Multiplexed Digital mRNA Profiling of the Inflammatory Response in the West Nile Swiss Webster Mouse Model

2014 ◽  
Vol 8 (10) ◽  
pp. e3216 ◽  
Author(s):  
José Peña ◽  
Jessica A. Plante ◽  
Alda Celena Carillo ◽  
Kimberly K. Roberts ◽  
Jennifer K. Smith ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Mouse Model ◽  
The West ◽  
West Nile ◽  
Mrna Profiling ◽  
Swiss Webster Mouse

The fight to save Uganda’s White Rhino

1964 ◽  
Vol 2 (01) ◽  
pp. 6-12
Keyword(s):  
The West ◽  
West Nile ◽  
White Rhino

In the West Nile District of Uganda lives a population of white rhino—those relies of a past age, cumbrous, gentle creatures despite their huge bulk—which estimates only 10 years ago, put at 500. But poachers live in the area, too, and official counts showed that white rhino were being reduced alarmingly. By 1959, they were believed to be diminished to 300.

scholarly journals Arginine methylation enhances the RNA chaperone activity of the West Nile virus host factor AUF1 p45

RNA ◽  
2016 ◽  
Vol 22 (10) ◽  
pp. 1574-1591 ◽  
Author(s):  
Susann Friedrich ◽  
Tobias Schmidt ◽  
Angelika Schierhorn ◽  
Hauke Lilie ◽  
Grit Szczepankiewicz ◽  
...  
Keyword(s):  
West Nile Virus ◽  
Arginine Methylation ◽  
Host Factor ◽  
Chaperone Activity ◽  
The West ◽  
West Nile ◽  
Rna Chaperone

Polymorphic microsatellite loci from the West Nile virus vector Culex tarsalis

2006 ◽  
Vol 6 (3) ◽  
pp. 680-682 ◽  
Author(s):  
JASON L. RASGON ◽  
MEERA VENKATESAN ◽  
CATHERINE J. WESTBROOK ◽  
MARY CLAIRE HAUER
Keyword(s):  
West Nile Virus ◽  
Microsatellite Loci ◽  
Virus Vector ◽  
Culex Tarsalis ◽  
The West ◽  
West Nile ◽  
Polymorphic Microsatellite

scholarly journals CD4+CD25+Foxp3+ regulatory T cells regulate immune balance in unexplained recurrent spontaneous abortion via the Toll-like receptor 4/nuclear factor-κB pathway

2020 ◽  
Vol 48 (12) ◽  
pp. 030006052098094
Author(s):  
Shuang Qin ◽  
Li Li ◽  
Jia Liu ◽  
Jinrui Zhang ◽  
Qing Xiao ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Inflammatory Response ◽  
Mouse Model ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Unexplained Recurrent Spontaneous Abortion ◽  
Tlr4 Antagonist

Objective The present study aimed to evaluate the effects of cluster of differentiation (CD)4+CD25+ forkhead box p3 (Foxp3)+ regulatory T cells (Tregs) on unexplained recurrent spontaneous abortion (URSA) and the associated mechanisms. Methods The proportion of CD4+CD25+Foxp3+ Tregs and inflammatory cytokine concentrations in the peripheral blood of women with URSA were measured by flow cytometry and enzyme-linked immunosorbent assay, respectively. CBA/JxDBA/2J mating was used to establish an abortion-prone mouse model and the model mice were treated with the Toll-like receptor 4 (TLR4) antagonist E5564 and the TLR4 agonist lipopolysaccharide. Results The proportion of CD4+CD25+Foxp3+ Tregs was decreased and the inflammatory response was increased in women with URSA. In the abortion-prone mouse model, E5564 significantly increased the proportion of CD4+CD25+Foxp3+ Tregs, decreased the inflammatory response, and increased Foxp3 mRNA and protein expression. Lipopolysaccharide had adverse effects on the abortion-prone model. Conclusions These data suggest that CD4+CD25+Foxp3+ Tregs regulate immune homeostasis in URSA via the TLR4/nuclear factor-κB pathway, and that the TLR4 antagonist E5564 may be a novel and potential drug for treating URSA.

scholarly journals Two Distinct Yersinia pestis Populations Causing Plague among Humans in the West Nile Region of Uganda

2016 ◽  
Vol 10 (2) ◽  
pp. e0004360 ◽  
Author(s):  
Laurel B. Respicio-Kingry ◽  
Brook M. Yockey ◽  
Sarah Acayo ◽  
John Kaggwa ◽  
Titus Apangu ◽  
...  
Keyword(s):  
Yersinia Pestis ◽  
The West ◽  
West Nile
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