scholarly journals Human antibody reaction against recombinant salivary proteins of Phlebotomus orientalis in Eastern Africa

2018 ◽  
Vol 12 (12) ◽  
pp. e0006981 ◽  
Author(s):  
Petra Sumova ◽  
Michal Sima ◽  
Tatiana Spitzova ◽  
Maha E. Osman ◽  
Anderson B. Guimaraes-Costa ◽  
...  
Keyword(s):  
Eastern Africa ◽  
Salivary Proteins ◽  
Human Antibody ◽  
Phlebotomus Orientalis ◽  
Antibody Reaction

scholarly journals Recombinant Salivary Proteins of Phlebotomus orientalis are Suitable Antigens to Measure Exposure of Domestic Animals to Sand Fly Bites

2016 ◽  
Vol 10 (3) ◽  
pp. e0004553 ◽  
Author(s):  
Michal Sima ◽  
Blanka Ferencova ◽  
Alon Warburg ◽  
Iva Rohousova ◽  
Petr Volf
Keyword(s):  
Domestic Animals ◽  
Sand Fly ◽  
Salivary Proteins ◽  
Phlebotomus Orientalis

scholarly journals Human Antibody Response toAedes albopictusSalivary Proteins: A Potential Biomarker to Evaluate the Efficacy of Vector Control in an Area of Chikungunya and Dengue Virus Transmission

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Souleymane Doucoure ◽  
François Mouchet ◽  
Sylvie Cornelie ◽  
Papa Makhtar Drame ◽  
Eric D’Ortenzio ◽  
...  
Keyword(s):  
Vector Control ◽  
Population Control ◽  
Control Strategies ◽  
Virus Transmission ◽  
Control Measures ◽  
Salivary Proteins ◽  
Human Antibody ◽  
Vector Population ◽  
Potential Biomarker ◽  
Species Specific

Aedesborne viruses represent public health problems in southern countries and threat to emerge in the developed world. Their control is currently based on vector population control. Much effort is being devoted to develop new tools to control such arbovirus. Recent findings suggest that the evaluation of human antibody (Ab) response to arthropod salivary proteins is relevant to measuring the level of human exposure to mosquito bites. Using an immunoepidemiological approach, the present study aimed to assess the usefulness of the salivary biomarker for measuring the efficacy ofAe. albopictuscontrol strategies in La Reunion urban area. The antisaliva Ab response of adult humans exposed toAe. albopictuswas evaluatedbefore and after vector control measures. Our results showed a significant correlation between antisaliva Ab response and the level of exposure to vectors bites. The decrease ofAe.albopictusdensity has been detected by this biomarker two weeks after the implementation of control measures, suggesting its potential usefulness for evaluating control strategies in a short time period. The identification of species specific salivary proteins/peptides should improve the use of this biomarker.

The Estimation of the Number of Binding Sites for Antibody on Antigen Molecules with Reference to Factor VIII and its Antibody

1976 ◽  
Vol 35 (02) ◽  
pp. 274-288 ◽  
Author(s):  
Judith Pool ◽  
Rosemary Biggs ◽  
R. G Miller
Keyword(s):  
Factor Viii ◽  
Binding Sites ◽  
Theoretical Basis ◽  
Human Antibody ◽  
Rabbit Antibody ◽  
Number Of Binding Sites ◽  
Theoretical Considerations

SummaryThe theoretical basis for determining the number of antibody sites on antigen molecules is examined. The theoretical considerations are applied to factor VIII molecules. Examples based on data available at the Oxford Haemophilia Centre are calculated to illustrate the approach. It is concluded that there are few sites on each factor VIII molecule for human antibody. The three antibodies for which reasonable data were available suggest 1–3 sites for human antibody. The data for rabbit antibody suggest 5–6 sites per factor VIII molecule.

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