scholarly journals Human antibody reaction against recombinant salivary proteins of Phlebotomus orientalis in Eastern Africa

2018 ◽  
Vol 12 (12) ◽  
pp. e0006981 ◽  
Author(s):  
Petra Sumova ◽  
Michal Sima ◽  
Tatiana Spitzova ◽  
Maha E. Osman ◽  
Anderson B. Guimaraes-Costa ◽  
...  
2016 ◽  
Vol 10 (3) ◽  
pp. e0004553 ◽  
Author(s):  
Michal Sima ◽  
Blanka Ferencova ◽  
Alon Warburg ◽  
Iva Rohousova ◽  
Petr Volf

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Souleymane Doucoure ◽  
François Mouchet ◽  
Sylvie Cornelie ◽  
Papa Makhtar Drame ◽  
Eric D’Ortenzio ◽  
...  

Aedesborne viruses represent public health problems in southern countries and threat to emerge in the developed world. Their control is currently based on vector population control. Much effort is being devoted to develop new tools to control such arbovirus. Recent findings suggest that the evaluation of human antibody (Ab) response to arthropod salivary proteins is relevant to measuring the level of human exposure to mosquito bites. Using an immunoepidemiological approach, the present study aimed to assess the usefulness of the salivary biomarker for measuring the efficacy ofAe. albopictuscontrol strategies in La Reunion urban area. The antisaliva Ab response of adult humans exposed toAe. albopictuswas evaluatedbefore and after vector control measures. Our results showed a significant correlation between antisaliva Ab response and the level of exposure to vectors bites. The decrease ofAe.albopictusdensity has been detected by this biomarker two weeks after the implementation of control measures, suggesting its potential usefulness for evaluating control strategies in a short time period. The identification of species specific salivary proteins/peptides should improve the use of this biomarker.


1976 ◽  
Vol 35 (02) ◽  
pp. 274-288 ◽  
Author(s):  
Judith Pool ◽  
Rosemary Biggs ◽  
R. G Miller

SummaryThe theoretical basis for determining the number of antibody sites on antigen molecules is examined. The theoretical considerations are applied to factor VIII molecules. Examples based on data available at the Oxford Haemophilia Centre are calculated to illustrate the approach. It is concluded that there are few sites on each factor VIII molecule for human antibody. The three antibodies for which reasonable data were available suggest 1–3 sites for human antibody. The data for rabbit antibody suggest 5–6 sites per factor VIII molecule.


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