scholarly journals The Cytoplasmic Location of Chicken Mx Is Not the Determining Factor for Its Lack of Antiviral Activity

PLoS ONE ◽  
2010 ◽  
Vol 5 (8) ◽  
pp. e12151 ◽  
Author(s):  
Camilla T. O. Benfield ◽  
Jon W. Lyall ◽  
Laurence S. Tiley
Keyword(s):  
Antiviral Activity ◽  
Determining Factor ◽  
Cytoplasmic Location

Quantum-Chemical Investigations of 5-Bromo-2'-Deoxyuridine Derivatives with Antiviral Activity

2006 ◽  
Vol 71 (5) ◽  
pp. 691-697
Author(s):  
Zhivko A. Velkov ◽  
Yasen Zh. Velkov ◽  
Alia V. Tadjer ◽  
Ivanka G. Stankova
Keyword(s):  
Amino Acids ◽  
Antiviral Activity ◽  
Quantum Chemical Calculations ◽  
Quantum Chemical ◽  
Molecular Descriptors ◽  
Structure Investigation ◽  
Determining Factor ◽  
Semiempirical Quantum Chemical Calculations

The article describes the results of semiempirical quantum-chemical calculations for a series of 3',5'-esters of 5-bromo-2'-deoxyuridine with amino acids or peptides. These compounds were synthesized and tested for antiviral activity as potential prodrugs of the parent 5-bromonucleoside. It was not clear why only some of the compounds were active. On the basis of structure investigation and the calculated molecular descriptors, it was found that the determining factor for obtaining appropriate prodrugs of 5-bromo-2'-deoxyuridine is the lipophilicity of the esters.

Antiviral activity of EPs® 7630 as assessed in a fibroblast-virus protection assay

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
C Thaele ◽  
A Janecki ◽  
AF Kiderlen ◽  
H Kolodziej
Keyword(s):  
Antiviral Activity ◽  
Protection Assay

Antiviral Activity of Fluorinated Heterocyclic Compounds

2016 ◽  
Author(s):  
Liubov Biliavska ◽  
Yulia Pankivska ◽  
Olga Povnitsa ◽  
Svitlana Zagorodnya ◽  
Ganna Gudz ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Heterocyclic Compounds ◽  
Strong Antiviral Activity
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