scholarly journals Human Antibody Response to Anopheles Saliva for Comparing the Efficacy of Three Malaria Vector Control Methods in Balombo, Angola

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e44189 ◽  
Author(s):  
Laura Brosseau ◽  
Papa Makhtar Drame ◽  
Patrick Besnard ◽  
Jean-Claude Toto ◽  
Vincent Foumane ◽  
...  
Author(s):  
Ahmed I Omotayo ◽  
Adeolu T Ande ◽  
Adedayo O Oduola ◽  
Abiodun K Olakiigbe ◽  
Aishat K Ghazali ◽  
...  

Abstract Malaria is a leading public health challenge causing mortality and morbidity in sub-Saharan Africa. Prominent malaria vector control methods employed in sub-Saharan Africa include Long Lasting Insecticide Nets (LLINs) and Indoor Residual spraying (IRS). This study investigated knowledge, attitude and practices (KAP) of malaria vector control methods in Lagos, South-West Nigeria. Structured questionnaires were employed for the cross-sectional survey which was carried out between May and August 2018. Multi-stage sampling technique was used to select Lagos Mainland, Kosofe, and Ojo local government areas (LGAs). Five hundred and twenty questionnaires were used for the study. Data were analyzed for descriptive statistics, whereas χ 2 was used to determine influence of respondents’ LGA, level of education and type of dwelling on respondents’ attitude and practice. Respondents’ LGAs have no significant impact on attitude and practice to malaria vector control methods. However, ‘level of education’ as well as ‘type of dwelling structure’ impacted significantly on some practices and attitude. Basically, IRS is the major tool employed in malaria vector control, but sometimes it is used in combination with other methods. A good number of residents also use LLINs. ‘Choice of method’ employed is mainly based on the effectiveness of method. General perception about LLINs and IRS is that they are effective, cheap and safer. Considering the widespread use of IRS and LLINs for malaria vector control in Lagos, implementation of malaria control programs should consider KAP to these two strategies.


2021 ◽  
Vol 6 (4) ◽  

Background: Malaria occurs mostly in poor tropical and subtropical areas of the world and still a leading cause of illness and death. This study aimed to explore the community knowledge, attitudes and practices towards malaria vector control methods in Rwanda. Methods: This research was conducted under community-based cross-sectional study. Study was conducted in Ruhango district, located in South province of Rwanda. A number of 385 participants were selected using a two-stage randomized cluster sampling procedure and subjected to a tested structured questionnaire for data collection. The data were coded and entered using Kobo Collect Toolbox, and transferred to SPSS for statistical analysis. Results: More than a half of respondents were females (57.7%), married (69.4%), had attended school (89.4%) and 89.6% were farmers. The overall knowledge score showed that 41.0% had low knowledge about malaria vector control methods. Overall, 33.8% of the respondents had positive attitudes towards MVCM. The overall practice score indicated 24.7% of respondents had good on MVCM. People with high level of knowledge towards malaria vector control methods were less likely to have good practices on malaria vector control methods than people with medium and low level of knowledge towards MVCM (OR=0.04; 95%CI: [0.005-0.30]; p<0.001) and that people with positive attitudes were 1.97 times more likely having good practices than people with neutral and negative attitudes towards malaria vector control methods (OR=1.97; 95%CI: [1.08-3.59]; p<0.001). Conclusion: Malaria vector control campaigns accompanied with education for behavioural change should be considered to ensure householders’ participation and cooperation in the Integrated Vector Management (IVM) programme. Moreover, continuous evaluation and monitoring of IVM as well as conducting more surveys on KAP are recommended to improve malaria control measures and to identify indicators for effective, successful, and sustainable malaria elimination programme.


PLoS ONE ◽  
2010 ◽  
Vol 5 (12) ◽  
pp. e15596 ◽  
Author(s):  
Papa Makhtar Drame ◽  
Anne Poinsignon ◽  
Patrick Besnard ◽  
Sylvie Cornelie ◽  
Jacques Le Mire ◽  
...  

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Blaženka D. Letinić ◽  
Marinela Contreras ◽  
Yael Dahan-Moss ◽  
Ingrid Linnekugel ◽  
José de la Fuente ◽  
...  

Abstract Background Anopheles arabiensis is an opportunistic malaria vector that rests and feeds outdoors, circumventing current indoor vector control methods. Furthermore, this vector will readily feed on both animals and humans. Targeting this vector while feeding on animals can provide an additional intervention for the current vector control activities. Previous results have displayed the efficacy of using Subolesin/Akirin ortholog vaccines for the control of multiple ectoparasite infestations. This made Akirin a potential antigen for vaccine development against An. arabiensis. Methods The efficacy of three antigens, namely recombinant Akirin from An. arabiensis, recombinant Akirin from Aedes albopictus, and recombinant Q38 (Akirin/Subolesin chimera) were evaluated as novel interventions for An. arabiensis vector control. Immunisation trials were conducted based on the concept that mosquitoes feeding on vaccinated balb/c mice would ingest antibodies specific to the target antigen. The antibodies would interact with the target antigen in the arthropod vector, subsequently disrupting its function. Results All three antigens successfully reduced An. arabiensis survival and reproductive capacities, with a vaccine efficacy of 68–73%. Conclusions These results were the first to show that hosts vaccinated with recombinant Akirin vaccines could develop a protective response against this outdoor malaria transmission vector, thus providing a step towards the development of a novel intervention for An. arabiensis vector control. Graphic Abstract


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