scholarly journals Impaired Acetylcholine-Induced Endothelium-Dependent Aortic Relaxation by Caveolin-1 in Angiotensin II-Infused Apolipoprotein-E (ApoE−/−) Knockout Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58481 ◽  
Author(s):  
Sai Wang Seto ◽  
Smriti M. Krishna ◽  
Hongyou Yu ◽  
David Liu ◽  
Surabhi Khosla ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Apolipoprotein E ◽  
Knockout Mice ◽  
Caveolin 1 ◽  
Apoe Knockout Mice

scholarly journals Endothelial Gab1 Deletion Accelerates Angiotensin II-Dependent Vascular Inflammation and Atherosclerosis in Apolipoprotein E Knockout Mice

2012 ◽  
Vol 76 (8) ◽  
pp. 2031-2040 ◽  
Author(s):  
Kaori Higuchi ◽  
Yoshikazu Nakaoka ◽  
Wataru Shioyama ◽  
Yoh Arita ◽  
Takahiro Hashimoto ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Apolipoprotein E ◽  
Knockout Mice ◽  
Vascular Inflammation ◽  
Apolipoprotein E Knockout Mice

scholarly journals Inhibition of Diet-Induced Atherosclerosis and Endothelial Dysfunction in Apolipoprotein E/Angiotensin II Type 1A Receptor Double-Knockout Mice

Circulation ◽  
2004 ◽  
Vol 110 (19) ◽  
pp. 3062-3067 ◽  
Author(s):  
Sven Wassmann ◽  
Thomas Czech ◽  
Martin van Eickels ◽  
Ingrid Fleming ◽  
Michael Böhm ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Endothelial Dysfunction ◽  
Apolipoprotein E ◽  
Knockout Mice ◽  
Double Knockout

scholarly journals Effect of irradiation and bone marrow transplantation on angiotensin II-induced aortic inflammation in ApoE knockout mice

2018 ◽  
Vol 276 ◽  
pp. 74-82 ◽  
Author(s):  
Jyoti Patel ◽  
Gillian Douglas ◽  
Alastair G. Kerr ◽  
Ashley B. Hale ◽  
Keith M. Channon
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Angiotensin Ii ◽  
Knockout Mice ◽  
Marrow Transplantation ◽  
Apoe Knockout Mice

scholarly journals Angiotensin II induces extracellular matrix metalloproteinase inducer expression via an AT1R dependent pathway in aortic atherosclerotic plaque in apolipoprotein E knockout mice

2011 ◽  
Vol 13 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Li-xia Yang ◽  
Zhi-hua Yang ◽  
Rui-wei Guo ◽  
Jin-shan Ye ◽  
Hong Liu
Keyword(s):  
Extracellular Matrix ◽  
Angiotensin Ii ◽  
Matrix Metalloproteinase ◽  
Protein Expression ◽  
Atherosclerotic Plaque ◽  
Knockout Mice ◽  
Ang Ii ◽  
Extracellular Matrix Metalloproteinase Inducer ◽  
Apolipoprotein E Knockout Mice ◽  
Apoe Knockout Mice

The pathogenesis of acute coronary syndrome is rupture of vulnerable plaque. Extracellular matrix metalloproteinase inducer (EMMPRIN) is reported to have a important role in the destabilization of atheroma. Objectives: this investigation examined the effect of angiotensin II (Ang II) on EMMPRIN expression in atherosclerotic plaques in ApoE knockout mice. Methods: ApoE knockout mice were fed a high fat diet to establish an atherosclerosis model then intervention was made with Ang II and valsartan. EMMPRIN gene and its protein expression were measured by real-time PCR immunohistochemistry, and Western blot. Results: EMMPRIN gene and protein expression intervened with Ang II were significantly increased; valsartan could inhibit the effect of Ang II. Conclusion: Ang II up-regulated EMMPRIN expression in atherosclerotic plaque via AT1R, and valsartan could inhibit the effect of Ang II.

scholarly journals UCP-2 is involved in angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0179743 ◽  
Author(s):  
Peng Yan ◽  
Ken Chen ◽  
Qiang Wang ◽  
Dachun Yang ◽  
De Li ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Angiotensin Ii ◽  
Aortic Aneurysm ◽  
Apolipoprotein E ◽  
Knockout Mice ◽  
Abdominal Aortic ◽  
Apolipoprotein E Knockout Mice
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