Endothelial NO Synthase Gene Polymorphisms and Risk of Ischemic Stroke in Asian Population: A Meta-Analysis

Abstract Background Prodynorphin (PDYN) gene polymorphisms have been linked with opioid dependence (OD) with conflicting outcomes, the aim of this study is to synthesize the existing evidence of the association between PDYN polymorphisms and OD susceptibility. Methods Four databases including PubMed, EMBASE, Web of Science, and Wanfang were retrieved for relevant studies before August, 2018. All identified studies were evaluated using predetermined inclusion and exclusion criteria. Summary odds ratio (OR) and 95% confidence interval (95%CI) were calculated to appraise the association. Statistical analysis was performed using RevMan 5.3 software. Results A total of seven case-control studies with 3129 cases and 3289 controls were recruited in the meta-analysis. For rs910080, rs1997794, rs1022563, and rs2235749 polymorphisms of PDYN gene, there were six, four, five, and four studies eventually included, respectively. The findings indicated that rs910080 polymorphism was significantly correlated with OD among Asian population under allelic model (A vs. G, OR = 1.30, 95% CI 1.04–1.62, P = 0.02, FDR = 0.05) and dominant model (AA+AG vs. GG, OR = 1.25, 95% CI 1.04–1.51, P = 0.02, FDR = 0.05). However, rs1022563, rs1997794 and rs2235749 polymorphisms did not appear to associate with OD susceptibility. Conclusions There existed a significant association between rs1022563 polymorphism and OD among Asian population. As the included studies were not adequate to guarantee a robust and convincing conclusion, future studies with larger sample size among more ethnicities are recommended.

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Associations of KCNQ1 Polymorphisms with the Risk of Type 2 Diabetes Mellitus: An Updated Meta-Analysis with Trial Sequential Analysis

Journal of Diabetes Research ◽

10.1155/2020/7145139 ◽

2020 ◽

Vol 2020 ◽

pp. 1-11

Author(s):

Xiao-xuan Yu ◽

Min-qi Liao ◽

Yu-fei Zeng ◽

Xu-ping Gao ◽

Yan-hua Liu ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Gene Polymorphisms ◽

Sequential Analysis ◽

Meta Analysis ◽

Asian Population ◽

Trial Sequential Analysis ◽

Case Control Studies

Background. Previous studies have examined the role of the KQT-like subfamily Q member1 (KCNQ1) gene polymorphisms on the risk of type 2 diabetes mellitus (T2DM), but the findings are inconclusive. Objective. To examine the association between the KCNQ1 gene polymorphisms and the risk of T2DM using an updated meta-analysis with an almost tripled number of studies. Methods. Five electronic databases, such as PubMed and Embase, were searched thoroughly for relevant studies on the associations between seven most studied KCNQ1 gene polymorphisms, including rs2237892, rs2237897, rs2237895, rs2283228, rs231362, rs151290, and rs2074196, and T2DM risk up to September 14, 2019. The summary odds ratios (ORs) with their 95% confidence intervals (CIs) were applied to assess the strength of associations in the random-effects models. We used the trial sequential analysis (TSA) to measure the robustness of the evidence. Results. 49 publications including 55 case-control studies (68,378 cases and 66,673 controls) were finally enrolled. In overall analyses, generally, increased T2DM risk was detected for rs2237892, rs2237895, rs2283228, rs151290, and rs2074196, but not for rs231362 under all genetic models. The ORs and 95% CIs for allelic comparison were 1.23 (1.14-1.33) for rs2237892, 1.21 (1.16-1.27) for rs2237895, 1.27 (1.11-1.46) for rs2237897, 1.25 (1.09-1.42) for rs2283228, 1.14 (1.03-1.27) for rs151290, 1.31 (1.23-1.39) for rs2074196, and 1.16 (0.83, 1.61) for rs231362. Stratified analyses showed that associations for rs2237892, rs2237895, rs2283228, and rs151290 were more evident among Asians than Caucasians. TSA demonstrated that the evidence was sufficient for all polymorphisms in this study. The genotypes of the three SNPs (rs2237892, rs2283228, and rs231362) were significantly correlated with altered KCNQ1 gene expression. Conclusion. This meta-analysis suggested that KCNQ1 gene polymorphisms (rs2237892, rs2283228, rs2237895, rs151290, and rs2074196) might be the susceptible factors for T2DM, especially among Asian population.

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Association between CASP-8 gene polymorphisms and cancer risk in some Asian population based on a HuGE review and meta-analysis

Genetics and Molecular Research ◽

10.4238/2013.february.28.3 ◽

2013 ◽

Vol 12 (4) ◽

pp. 6466-6476 ◽

Cited By ~ 5

Author(s):

Y.J. Zhang ◽

X.P. Zhong ◽

Y. Chen ◽

S.R. Liu ◽

G. Wu ◽

...

Keyword(s):

Cancer Risk ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Asian Population ◽

Population Based

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IL-17A (-197G/A) and IL-17F (7488T/C) gene polymorphisms and cancer risk in Asian population: a meta-analysis

OncoTargets and Therapy ◽

10.2147/ott.s62781 ◽

2014 ◽

pp. 703 ◽

Cited By ~ 5

Author(s):

Wei Dai ◽

Qing Zhou ◽

Xuexin Tan ◽

Changfu sun

Keyword(s):

Cancer Risk ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Asian Population

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Associations of the Angiotensin II Type 1 Receptor A 1166 C and the Endothelial NO Synthase G 894 T Gene Polymorphisms With Silent Subcortical White Matter Lesions in Essential Hypertension

Stroke ◽

10.1161/01.str.0000177867.39769.cb ◽

2005 ◽

Vol 36 (9) ◽

pp. 1869-1873 ◽

Cited By ~ 33

Author(s):

Léon H.G. Henskens ◽

Abraham A. Kroon ◽

Martin P.J. van Boxtel ◽

Paul A.M. Hofman ◽

Peter W. de Leeuw

Keyword(s):

Essential Hypertension ◽

Angiotensin Ii ◽

White Matter ◽

Gene Polymorphisms ◽

White Matter Lesions ◽

Subcortical White Matter ◽

No Synthase ◽

Endothelial No Synthase

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The rs11833579 and rs12425791 polymorphisms and risk of ischemic stroke in an Asian population: A meta-analysis

Thrombosis Research ◽

10.1016/j.thromres.2012.06.014 ◽

2012 ◽

Vol 130 (3) ◽

pp. e95-e102 ◽

Cited By ~ 7

Author(s):

Gu Lian ◽

Yan Yan ◽

Long Jianxiong ◽

Xie Juanjuan ◽

Chen Qing ◽

...

Keyword(s):

Ischemic Stroke ◽

Meta Analysis ◽

Asian Population

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Significant Association between Microrna Gene Polymorphisms and Type 2 Diabetes Mellitus Susceptibility in Asian Population: A Meta-Analysis

Iranian Journal of Public Health ◽

10.18502/ijph.v49i5.3200 ◽

2020 ◽

Author(s):

Zhifang DENG ◽

Wenqi GAO ◽

Wei LUO ◽

Li AI ◽

Min HU

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Gene Polymorphisms ◽

Meta Analysis ◽

Asian Population ◽

Healthy Population ◽

Nucleotide Polymorphisms ◽

Microrna Gene

Background: The gene polymorphisms in microRNA might relate to susceptibility of type 2 diabetes mellitus (T2DM). However, the results of existing studies were inconsistent and obscure. To investigate the precise associations between microRNA gene polymorphisms and T2DM risk, the present meta-analysis was performed. Methods: The literatures were searched from four electronic databases, PubMed, Embase, CNKI and Wanfang. Subsequently, odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were both used to evaluate the associations between two single nucleotide polymorphisms (SNPs) (microRNA146a rs2910164 (G>C), microRNA124a rs531564 (C>G)) and risk of T2DM in Asian population. Results: Totally, there were 4 studies included in our present analysis in the language of English and Chinese. There were partly significant associations between susceptibility of T2DM and SNPs (microRNA146a rs2910164 (G>C), microRNA124a rs531564 (C>G)). The G allele in microRNA146a rs2910164 (G>C) and C allele in microRNA124a rs531564 (C>G) both presented remarkably reduced risk of T2DM when compared with the healthy population. Conclusion: The microRNA146a rs2910164 (G allele) and microRNA124a rs531564 (C allele) might function as protective factors in the pathogenetic process of T2DM in Asian population.

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