scholarly journals Association between prodynorphin gene polymorphisms and opioid dependence susceptibility: a meta-analysis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Chang-wang Wang ◽  
Min Ma ◽  
Wei-guang Lu ◽  
Ru-qin Luo
Keyword(s):  
Gene Polymorphisms ◽  
Opioid Dependence ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control Studies ◽  
Exclusion Criteria ◽  
Future Studies ◽  
Larger Sample ◽  
Allelic Model ◽  
Summary Odds Ratio

Abstract Background Prodynorphin (PDYN) gene polymorphisms have been linked with opioid dependence (OD) with conflicting outcomes, the aim of this study is to synthesize the existing evidence of the association between PDYN polymorphisms and OD susceptibility. Methods Four databases including PubMed, EMBASE, Web of Science, and Wanfang were retrieved for relevant studies before August, 2018. All identified studies were evaluated using predetermined inclusion and exclusion criteria. Summary odds ratio (OR) and 95% confidence interval (95%CI) were calculated to appraise the association. Statistical analysis was performed using RevMan 5.3 software. Results A total of seven case-control studies with 3129 cases and 3289 controls were recruited in the meta-analysis. For rs910080, rs1997794, rs1022563, and rs2235749 polymorphisms of PDYN gene, there were six, four, five, and four studies eventually included, respectively. The findings indicated that rs910080 polymorphism was significantly correlated with OD among Asian population under allelic model (A vs. G, OR = 1.30, 95% CI 1.04–1.62, P = 0.02, FDR = 0.05) and dominant model (AA+AG vs. GG, OR = 1.25, 95% CI 1.04–1.51, P = 0.02, FDR = 0.05). However, rs1022563, rs1997794 and rs2235749 polymorphisms did not appear to associate with OD susceptibility. Conclusions There existed a significant association between rs1022563 polymorphism and OD among Asian population. As the included studies were not adequate to guarantee a robust and convincing conclusion, future studies with larger sample size among more ethnicities are recommended.

scholarly journals Associations of KCNQ1 Polymorphisms with the Risk of Type 2 Diabetes Mellitus: An Updated Meta-Analysis with Trial Sequential Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Xiao-xuan Yu ◽  
Min-qi Liao ◽  
Yu-fei Zeng ◽  
Xu-ping Gao ◽  
Yan-hua Liu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphisms ◽  
Sequential Analysis ◽  
Meta Analysis ◽  
Asian Population ◽  
Trial Sequential Analysis ◽  
Case Control Studies

Background. Previous studies have examined the role of the KQT-like subfamily Q member1 (KCNQ1) gene polymorphisms on the risk of type 2 diabetes mellitus (T2DM), but the findings are inconclusive. Objective. To examine the association between the KCNQ1 gene polymorphisms and the risk of T2DM using an updated meta-analysis with an almost tripled number of studies. Methods. Five electronic databases, such as PubMed and Embase, were searched thoroughly for relevant studies on the associations between seven most studied KCNQ1 gene polymorphisms, including rs2237892, rs2237897, rs2237895, rs2283228, rs231362, rs151290, and rs2074196, and T2DM risk up to September 14, 2019. The summary odds ratios (ORs) with their 95% confidence intervals (CIs) were applied to assess the strength of associations in the random-effects models. We used the trial sequential analysis (TSA) to measure the robustness of the evidence. Results. 49 publications including 55 case-control studies (68,378 cases and 66,673 controls) were finally enrolled. In overall analyses, generally, increased T2DM risk was detected for rs2237892, rs2237895, rs2283228, rs151290, and rs2074196, but not for rs231362 under all genetic models. The ORs and 95% CIs for allelic comparison were 1.23 (1.14-1.33) for rs2237892, 1.21 (1.16-1.27) for rs2237895, 1.27 (1.11-1.46) for rs2237897, 1.25 (1.09-1.42) for rs2283228, 1.14 (1.03-1.27) for rs151290, 1.31 (1.23-1.39) for rs2074196, and 1.16 (0.83, 1.61) for rs231362. Stratified analyses showed that associations for rs2237892, rs2237895, rs2283228, and rs151290 were more evident among Asians than Caucasians. TSA demonstrated that the evidence was sufficient for all polymorphisms in this study. The genotypes of the three SNPs (rs2237892, rs2283228, and rs231362) were significantly correlated with altered KCNQ1 gene expression. Conclusion. This meta-analysis suggested that KCNQ1 gene polymorphisms (rs2237892, rs2283228, rs2237895, rs151290, and rs2074196) might be the susceptible factors for T2DM, especially among Asian population.

scholarly journals Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-13 ◽  
Author(s):  
Chao Shan ◽  
Abasijiang Aisaiti ◽  
Zhong Peng Wu ◽  
Ting Ting Wang ◽  
Jin Zhao
Keyword(s):  
Gene Polymorphisms ◽  
Large Scale ◽  
Meta Analysis ◽  
Critical Role ◽  
Case Control ◽  
Recessive Model ◽  
Immune Gene ◽  
Case Control Studies ◽  
Codominant Model ◽  
Allelic Model

Background. Periodontitis is a kind of chronic infectious disease, affecting the health of billions of people. In recent years, a number of studies have shown that multiple immune gene polymorphisms are associated with the susceptibility to periodontitis, among which TLR-2 plays a critical role in periodontitis. But most of the studies reported TLR-2 gene polymorphism and susceptibility to periodontitis are not consistent. Therefore, we included all eligible studies in our study for further meta-analysis. Methods. We used electronic databases, including CNKI, PubMed, EMBASE, and Web of Science databases, and relevant research published through June, 2020. Selecting studies involved case-control trials. For all eligibility studies, odds ratios (ORs) and 95% confidence intervals (95% CI) are provided or can be calculated from the study data. The size of the combined effect was calculated using STATA 15.0. Results. Our meta-analysis included 14 articles representing 18 case-control studies with a total of 3873 cases and 3438 control subjects. Significant association was found between periodontitis and TLR-2 rs1898830 polymorphism under the allelic model (A allele vs. G allele: p=0.014, OR=1.208, 95% CI: 1.039-1.406), recessive model (GG vs. GA+AA: p=0.028, OR=0.755, 95% CI: 0.588-0.970), and codominant model (GG VS. AA: p=0.014, OR=0.681, 95% CI: 0.501-0.925). In subgroup analysis, TLR-2 rs5743708 polymorphism was associated with periodontitis risk in Asians under an allelic model (G allele vs. A allele: p=0.017, OR=12.064, 95% CI: 1.570-92.688), dominant model (GA+AA vs.GG: p=0.016, OR=0.08, 95% CI: 0.010-0.620), and codominant model (GA VS. GG: p=0.016, OR=1.026, 95% CI: 0.821-1.282). Conclusion. The TLR-2 rs1898830, rs5743708 polymorphism may be associated with susceptibility to periodontitis. In the future, genome-wide approaches and large-scale, multiethnic case-control trials are still needed.

scholarly journals Interleukin-6 gene −572 G > C polymorphism and myocardial infarction risk

Open Medicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 376-383
Author(s):  
He-guo Ding ◽  
Yan-wei Yin ◽  
Sun-lin Liu
Keyword(s):  
Myocardial Infarction ◽  
Interleukin 6 ◽  
Protective Factor ◽  
Web Of Science ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Future Studies ◽  
Larger Sample ◽  
Insight Into

AbstractIntroductionThe association between interleukin-6 (IL-6) gene −572 G^C polymorphism and myocardial infarction (MI) risk has not been established. We adopted this meta-analysis for further insight into the case–control studies.Materials and methodsTo investigate the genetic association, we searched multiple databases, including Web of Science, EMbase, CBM disc, PubMed and CNKI. Also, we manually identified the searched references. All the statistical analyses were conducted using Stata 11.0.ResultsA total of five studies were identified, involving 2,526 MI cases and 3,027 controls. The results revealed a significant association between IL-6 gene −572 G^C polymorphism and MI, implying that the IL-6 gene −572 C allele may be a protective factor for MI (for C allele vs K allele: OR = 0.85, 95% CI = 0.73–0.99, p = 0.041; for C/C vs G/G: OR = 0.55, 95% CI = 0.31–0.98, p = 0.044; for C/C vs G/C + G/G: OR = 0.60, 95% CI = 0.41–0.89, p = 0.011). However, in the subgroup analysis with regard to ethnicity, no significant correlation was identified between IL-6 gene −572 G^C polymorphism and MI among Europeans.ConclusionThe IL-6 gene −572 C allele may be a protective factor for MI. Future studies involving larger sample bases are still recommended.

scholarly journals Association of ABO Polymorphisms and Cancer/Cardiocerebrovascular Disease: a Meta-analysis

2019 ◽  
Author(s):  
Yanxia Li ◽  
Luyang Liu ◽  
Yubei Huang ◽  
Hong Zheng ◽  
Lian Li
Keyword(s):  
Gene Polymorphisms ◽  
Web Of Science ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Exclusion Criteria ◽  
Bias Assessment ◽  
Heterogeneity Test ◽  
The Relationship ◽  
Eligible Case

Abstract Background: ABO gene polymorphisms have been reported to be associated with the risk of multiple cancers and cardiocerebrovascular diseases. However, the results remained controversial. In this study, we conducted a systematic review and meta-analysis to clarify the association between two SNPs (rs505922 and rs657152) in ABO gene and cancers/cardiocerebrovascular diseases. Method: All eligible case-control studies come from PubMed, Embase and Web of Science up to Jan. 1, 2019. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the corresponding associations. Sensitivity analysis, publication bias assessment, and heterogeneity test were performed using STATA 12.0. Results: A total of eighteen articles involving twenty-nine case-control populations were included according to inclusion and exclusion criteria. Eleven populations (16,929 cases and 23,941 controls) were used to evaluate the relationship between rs505922 and overall cancers and nine populations (22,275 cases and 71,549 controls) were included to assess the association between rs505922 and cardiocerebrovascular diseases. The results showed a significant association between the rs505922 polymorphism and cancers (CvsT: OR=1.13, 95% CI=1.04-1.22, P=0.003), and cardiocerebrovascular diseases (OR=1.36, 95%CI=1.19-1.57, P<0.001). Four populations (5,158 cases and 7,021 controls) were included to evaluate association between rs657152 and cancers and five populations (8,105 cases and 6,712 controls) were included to estimate the relationship between rs657152 and cardiocerebrovascular diseases. The result of meta-analysis reveals that rs657152 was significantly associated with cancers (OR=1.16, 95%CI=1.09-1.24, P<0.001) and cardiocerebrovascular diseases (OR=1.54, 95%CI=1.24-1.92, P<0.001). Conclusion: Our study suggested that ABO polymorphisms may serve as a risk factor of cancers and cardiocerebrovascular diseases.

scholarly journals Association of Interleukin-16 rs4778889 T>C Gene Polymorphism with Cancer Risk: a Meta-analysis

2020 ◽  
Author(s):  
Qin Lei ◽  
Zhao Jiawen ◽  
Zhao Yutong ◽  
Ma Chenjun ◽  
Li Chaobin ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Gene Polymorphism ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Sensitivity Analyses ◽  
Nucleotide Polymorphisms ◽  
Case Control Studies ◽  
Single Nucleotide ◽  
The Relationship ◽  
Larger Sample

Abstract BACKGROUND: Rs4778889 T>C is one of the single nucleotide polymorphisms (SNPs) in interleukin-16 (IL-16). As a growth factor, IL-16 might play a significant impact on cancer formation. Several studies have investigated the relationship between IL-16 rs4778889 T>C gene polymorphisms and cancer risk, but the results are contradictory. We conducted a meta-analysis on the association between IL-16 rs4778889 T>C gene polymorphism and cancer risk. METHODS: Twelve case–control studies with 3066 cases and 4433 controls from Web of Science, PubMed, and Embase databases were included. The data was analyzed using the STATA software and the combined odds ratio (ORs) and the corresponding 95% confidence interval (CIs) were used to identify the correlation strength. RESULTS: Our results show that no significant associations were observed between the IL-16 rs4778889 T>C gene polymorphisms and cancer risk in all genetic models (C vs. T: OR=1.06, 95% CI: 0.90–1.26, Ph<0.001; CC vs. TT: OR=1.07, 95% CI: 0.71–1.62, Ph<0.001; CT vs. TT: OR=1.07, 95% CI: 0.91–1.26, Ph=0.002; CC+CT vs. TT: OR=1.08, 95% CI: 0.90–1.30, Ph<0.001; CC vs. CT+TT: OR=1.04, 95% CI: 0.73–1.50, Ph=0.001). Subgroup and sensitivity analyses also were performed. CONCLUSIONS: The results of this meta-analysis indicate that there are no significant associations between IL-16 rs4778889 T>C gene polymorphisms and cancer risk. To verify these results, further studies with larger sample size and multiracial populations are needful. Keywords: IL-16, polymorphisms, cancer, meta-analysis

scholarly journals Relevance of hMLH1 -93G>A, 655A>G and 1151T>A polymorphisms with colorectal cancer susceptibility: a meta-analysis based on 38 case-control studies

2018 ◽  
Vol 64 (10) ◽  
pp. 942-951 ◽  
Author(s):  
Mohammad Zare ◽  
Jamal Jafari-Nedooshan ◽  
Mohammadali Jafari ◽  
Hossein Neamatzadeh ◽  
Seyed Mojtaba Abolbaghaei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Biomedical Literature ◽  
Case Control Studies ◽  
Increased Risk ◽  
Comprehensive Search ◽  
Meta Analyses

SUMMARY OBJECTIVE: There has been increasing interest in the study of the association between human mutL homolog 1 (hMLH1) gene polymorphisms and risk of colorectal cancer (CRC). However, results from previous studies are inconclusive. Thus, a meta-analysis was conducted to derive a more precise estimation of the effects of this gene. METHODS: A comprehensive search was conducted in the PubMed, EMBASE, Chinese Biomedical Literature databases until January 1, 2018. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the association. RESULTS: Finally, 38 case-control studies in 32 publications were identified met our inclusion criteria. There were 14 studies with 20668 cases and 19533 controls on hMLH1 −93G>A, 11 studies with 5,786 cases and 8,867 controls on 655A>G and 5 studies with 1409 cases and 1637 controls on 1151T>A polymorphism. The combined results showed that 655A>G and 1151T>A polymorphisms were significantly associated with CRC risk, whereas −93G>A polymorphism was not significantly associated with CRC risk. As for ethnicity, −93G>A and 655A>G polymorphisms were associated with increased risk of CRC among Asians, but not among Caucasians. More interestingly, subgroup analysis indicated that 655A>G might raise CRC risk in PCR-RFLP and HB subgroups. CONCLUSION: Inconsistent with previous meta-analyses, this meta-analysis shows that the hMLH1 655A>G and 1151T>A polymorphisms might be risk factors for CRC. Moreover, the −93G>A polymorphism is associated with the susceptibility of CRC in Asian population.

scholarly journals Association Between Blood Circulating Vitamin D and Colorectal Cancer Risk in Asian Countries: A Systematic Review and Dose-Response Meta-analysis

2019 ◽  
Author(s):  
Lin Zhang ◽  
Huachun Zou ◽  
Yang Zhao ◽  
Chunlei Hu ◽  
Adejare (Jay) Atanda ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Vitamin D ◽  
Cancer Risk ◽  
Dose Response ◽  
Meta Analysis ◽  
Asian Population ◽  
Colorectal Cancer Risk ◽  
Asian Countries ◽  
Case Control Studies ◽  
Vitamin D Levels

ABSTRACTObjectivesTo assess the association between blood circulating Vitamin D levels and colorectal cancer risk in the Asian population.DesignThis is a systematic review and dose-response meta-analysis of observational studies that investigated the relationship between blood circulating Vitamin D levels and colorectal cancer risk in the Asian population.Data SourcesRelevant studies were identified through a literature search in MEDLINE, EMBASE, and Web of Science from January 1980 to 31 January 2019. Eligibility criteria: original studies published in peer-reviewed journals investigating the association between blood circulating Vitamin D levels and the risk of colorectal cancer and/or adenoma in Asian countries.Data extraction and synthesisTwo authors independently extracted data and assessed the quality of included studies. Study-specific ORs were pooled using a random-effects model. A dose-response meta-analysis was performed with generalized least squares regression. We applied the Newcastle-Ottawa Scale quality assessment to evaluate the quality of the selected studies.ResultsThe eight included studies encompassed a total of 2,916 cases and 6,678 controls. The pooled ORs of colorectal cancer for the highest versus lowest categories of blood circulating Vitamin D levels was 0.75 [95% CI, 0.58-0.97] up to 36.5 ng/mL in the Asian population. There was heterogeneity among the studies (I2=53.9%, Pheterogeneity=0.034). The dose-response meta-analysis indicated a significant linear relationship (Pnon-linearity=0.11). An increment of 16 ng/mL in blood circulating Vitamin D level corresponded to an OR of 0.79 [95% CI, 0.64-0.97].ConclusionsThe results of this meta□analysis indicate that blood circulating Vitamin D level is associated with decreased risk of colorectal cancer in Asian countries. The dose-response meta-analysis shows that the strength of this association among the Asian population is similar to that among the Western population. Our study suggests that the Asian population should improve nutritional status and maintain a higher level of blood circulating Vitamin D.Strengths and limitations of this studyOur study seeks to extend previous work by including a number of new studies and by distinguishing the Asian population explicitly.The number of included studies is not sufficient to provide a robust estimate, so the results should be interpreted in the context of the limitations of the available data.Heterogeneous definitions of blood circulating Vitamin D categories were used across studies. The variability in definitions could limit comparability between studies.Our study included seven case-control studies; the study design implies that the measurement of blood circulating Vitamin D is measured in individuals already diagnosed with colorectal cancer. Results from case-control studies need to be interpreted cautiously because of the potential for reverse causation.Time of blood sampling in relation to outcome ascertainment also varied among studies. Such cross-sectional measurements may not accurately reflect an individual’s Vitamin D status across time.

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