Background:
Ischemic stroke (IS) is a significant disease which threatens human health
condition. Genome-wide association studies (GWAS) have demonstrated that two intergenic single-
nucleotide polymorphisms (SNPs) rs11833579 and rs12425791 G>A on chromosome 12p13
are associated with IS susceptibility. However, later studies came to contradictory outcomes. Thus,
we carried out a meta-analysis to identify the association between nerve injury-induced protein 2
(NINJ2) gene polymorphisms (rs11833579 and rs12425791) and the risk of IS.
Methods:
PubMed, Embase, Web of Science, CBM, Wanfang, VIP, and CNKI databases were
searched until March 2019. Data was analyzed by RevMan 5.3 and STATA 12.0 software. The
pooled odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the strength of the
association.
Results:
Eighteen qualified articles were selected in total. For rs12425791 and rs11833579, a total
of 14055 cases with 13148 controls and 10635 cases with 10462 controls, respectively, were identified
for the present study. Our meta-analysis found that rs12425791 was associated with IS for
three genetic models (allele model: OR=1.04, 95% CI: 1.00-1.08, P=0.04; dominant model:
OR=1.06, 95% CI: 1.01-1.12, P=0.01 and heterozygous model: OR=1.07, 95% CI: 1.01-1.12,
P=0.02). Whereas rs11833579 polymorphism was not associated with IS among different genetic
models.
Conclusion:
NINJ2 gene rs12425791 confers a susceptible factor for IS, while there is no association
between NINJ2 gene rs11833579 and IS. Larger sample size studies should be performed to
find the association between NINJ2 gene and IS.
Endothelial NO Synthase Gene Polymorphisms and Risk of Ischemic Stroke in Asian Population: A Meta-Analysis
