scholarly journals Efficacy and Cardiotoxicity of Liposomal Doxorubicin-Based Chemotherapy in Advanced Breast Cancer: A Meta-Analysis of Ten Randomized Controlled Trials

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0133569 ◽  
Author(s):  
Meiyuan Xing ◽  
Feifei Yan ◽  
Sufen Yu ◽  
Peng Shen
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Randomized Controlled Trials ◽  
Liposomal Doxorubicin ◽  
Meta Analysis ◽  
Advanced Breast ◽  
Controlled Trials ◽  
Randomized Controlled

Fulvestrant in the treatment of advanced breast cancer: A systematic review and meta-analysis of randomized controlled trials

2010 ◽  
Vol 73 (3) ◽  
pp. 220-227 ◽  
Author(s):  
Antonis Valachis ◽  
Davide Mauri ◽  
Nikolaos P. Polyzos ◽  
Dimitris Mavroudis ◽  
Vassilis Georgoulias ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Advanced Breast Cancer ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Advanced Breast ◽  
Controlled Trials ◽  
Randomized Controlled

scholarly journals Poly(ADP-Ribose) Polymerase Inhibitors (PARPi) for Patients With Advanced Breast Cancer: a Meta-analysis of Randomized Controlled Trials

2020 ◽  
Author(s):  
YongCheng Su ◽  
XiaoGang Zheng
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Advanced Breast ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Polymerase Inhibitors

Abstract The authors have withdrawn this preprint due to erroneous posting.

scholarly journals Efficacy and Safety of Aidi Injection as an Adjuvant Therapy on Advanced Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Yihui Chai ◽  
Yunzhi Chen ◽  
Wen Li ◽  
Zhong Qin ◽  
Jie Gao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Advanced Breast Cancer ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Advanced Breast ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Randomized Controlled ◽  
Aidi Injection

Background. Aidi injection (ADI) is being used widely for breast cancer in China. However, the efficacy and safety of it need to be summarized. We conducted a systematic review and meta-analysis to compare ADI and non-ADI treatment for advanced breast cancer. Methods. We searched PubMed, EMBASE, CNKI, SinoMed, and CENTRAL from inception to Jan 2020 for randomized controlled trials (RCTs) with diagnosis of advanced breast cancer that compared the efficacy of ADI with non-ADI treatment. Two researchers screened the literature, extracted data, and evaluated risk of bias separately. The primary outcomes were overall response rate (ORR) and disease control rate (DCR). The secondary outcomes included the QOL, immune cells, and adverse events. Review Manager software was used for estimating risks of bias of included studies, data analysis, and plotting. The sensitivity analysis and the publication bias test were performed using the R language. I2 and chi-square tests were used to estimate heterogeneity. If P>0.1 or I2 < 40%, the fixed-effect model meta-analysis was performed. A random or fixed-effect analysis was used depending on the heterogeneity testing. Weighted mean difference (WMD) or standard mean difference (SMD) was used for analysis of continuous data, and the rate ratio (RR) was calculated for the dichotomous variable, respectively. Results. We included 14 studies with 1006 patients diagnosed as advanced breast cancer in total. The pooled effect showed that ADI increased ORR in advanced BC patients as an add-on therapy with little heterogeneity (RR = 1.14, 95% CI 1.03–1.27). DCR in BC patients could not be improved by ADI. ADI improved the KPS score in BC patients compared with chemotherapy alone (MD = 3.26, 95% CI 1.74–4.78). There were no improvements on immune markers except CD4/CD8 and NK%. Serum tumor markers CEA and CA153 were decreased while treated with ADI, but only one trial was involved. ADI decreased the numbers of myelosuppression in advanced BC patients, and AST, ALT, γ-GT, and CK-MB were all decreased. The sensitivity evaluation indicated that the result of the pooled effect size had good stability. Conclusion. This meta-analysis suggested that based on the existing evidence, treatment with ADI significantly changed the ORR of patients with advanced BC and improved their quality of life with few side effects. However, more randomized trials involving larger samples should be considered, and detailed mechanisms are needed to be uncovered.

Risk of hematological toxicities in patients with advanced breast cancer treated with everolimus: A meta-analysis of phase 3 randomized controlled trials.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e13087-e13087
Author(s):  
Anita Sultan ◽  
Kyaw Zin Thein ◽  
Sriman Swarup ◽  
Ruth D’Cunha ◽  
Fred L. Hardwicke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Advanced Breast Cancer ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Advanced Breast ◽  
Controlled Trials ◽  
Phase 3 ◽  
Randomized Controlled

scholarly journals Side effects of CDK4/6 inhibitors in the treatment of HR+/HER2− advanced breast cancer: a systematic review and meta-analysis of randomized controlled trials

2021 ◽  
Vol 10 (5) ◽  
pp. 5590-5599
Author(s):  
Lin Yang ◽  
Jingyi Xue ◽  
Zhengyu Yang ◽  
Meixue Wang ◽  
Ping Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Side Effects ◽  
Advanced Breast Cancer ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Advanced Breast ◽  
Controlled Trials ◽  
Randomized Controlled

A systematic review and meta- analysis of randomized controlled trials to evaluate the risk of pulmonary toxicities in patients with advanced breast cancer treated with everolimus.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e13086-e13086
Author(s):  
Sriman Swarup ◽  
Kyaw Zin Thein ◽  
Anita Sultan ◽  
Rachana Yendala ◽  
Fred L. Hardwicke ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Systematic Review ◽  
Advanced Breast Cancer ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Advanced Breast ◽  
Controlled Trials ◽  
Randomized Controlled
Sign in / Sign up

Export Citation Format

Share Document