scholarly journals Hemoglobin Constant Spring among Southeast Asian Populations: Haplotypic Heterogeneities and Phylogenetic Analysis

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0145230 ◽  
Author(s):  
Wittaya Jomoui ◽  
Goonnapa Fucharoen ◽  
Kanokwan Sanchaisuriya ◽  
Van Hoa Nguyen ◽  
Supan Fucharoen
Blood ◽  
1989 ◽  
Vol 73 (7) ◽  
pp. 1987-1992 ◽  
Author(s):  
GL Kropp ◽  
S Fucharoen ◽  
SH Embury

Abstract Hemoglobin Constant Spring is an elongation mutation of the alpha 2- globin locus that results in a thalassemic phenotype. It has a high prevalence in Asian populations. When inherited with other alpha- thalassemia determinants, the Constant Spring gene has the potential to cause severe forms of alpha-thalassemia. Accurate diagnosis of the condition with standard hemoglobin electrophoresis is unreliable due to the small to undetectable amounts of the mutant hemoglobin present. Because of the extensive sequence homology of the alpha 1 and alpha 2 loci, allele-specific hybridization to total genomic DNA containing the Constant Spring gene would not distinguish between heterozygous and homozygous hemoglobin Constant Spring. Selective enzymatic amplification of alpha 2-globin DNA sequences, however, allows unambiguous diagnoses to be made using allele-specific hybridization. This method is useful for providing accurate genetic counseling and prenatal diagnosis in populations and specific families in which precise diagnosis is important.


2017 ◽  
Vol 44 (8) ◽  
pp. 747-750 ◽  
Author(s):  
Wittaya Jomoui ◽  
Goonnapa Fucharoen ◽  
Kanokwan Sanchaisuriya ◽  
Nga Thi Nguyen ◽  
Hoa Van Nguyen ◽  
...  

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Woei-Yuh Saw ◽  
Erwin Tantoso ◽  
Husna Begum ◽  
Lihan Zhou ◽  
Ruiyang Zou ◽  
...  

2002 ◽  
Vol 59 (1-2) ◽  
pp. 57-69 ◽  
Author(s):  
Jennifer R Ovenden ◽  
Julie Lloyd ◽  
Stephen J Newman ◽  
Clive P Keenan ◽  
Leigh S Slater

2009 ◽  
Vol 19 (11) ◽  
pp. 2154-2162 ◽  
Author(s):  
Y.-Y. Teo ◽  
X. Sim ◽  
R. T.H. Ong ◽  
A. K.S. Tan ◽  
J. Chen ◽  
...  

2007 ◽  
Vol 86 (9) ◽  
pp. 665-669 ◽  
Author(s):  
Sanita Singsanan ◽  
Goonnapa Fucharoen ◽  
Onekham Savongsy ◽  
Kanokwan Sanchaisuriya ◽  
Supan Fucharoen

2013 ◽  
Vol 132 (1) ◽  
pp. 10-14 ◽  
Author(s):  
Goonnapa Fucharoen ◽  
Khomsan Yooyen ◽  
Attawut Chaibunruang ◽  
Supan Fucharoen

Water ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2311
Author(s):  
Geetha Maniam ◽  
Phaik Eong Poh ◽  
Thet Thet Htar ◽  
Wai Ching Poon ◽  
Lay Hong Chuah

The water situation in Southeast Asia has changed from one of relative abundance to one of relative scarcity. Conventional water management that strategized around the provision of adequate water supply to users has limited sustainability. Though nations in this region have adopted the United Nations Sustainable Development Plan into their water management framework, successful outcomes are limited thus far. Water literacy has a growing importance for improving water sustainability, especially in developing countries. A literature search was employed to extract data on the different dimensions of water literacy in Southeast Asia including the sources and consumption patterns, water governance and management, and sociodemographic elements as well as the various aspects of water related challenges faced. Results from the review and analysis show that a large proportion of Southeast Asian populations are not part of a water sustainable society, and this presents a major hurdle for the countries to meet United Nations Sustainable Development Goal 6 by 2030. Therefore, active cognitive engagement through the creation of a water literate environment is critical for breaking the chain of water illiteracy and to achieve long-term water sustainability in Southeast Asia countries. Overall, this paper provides a critical analysis on lessons learnt from the region that can be mirrored in other parts of the world.


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