Cardiac computed tomography-derived epicardial fat volume and attenuation independently distinguish patients with and without myocardial infarction

Background Aortic stiffness and epicardial fat relate to cardiovascular risk. Their relationship with each other and their role with hypertension, diabetes mellitus (DM), and myocardial infarction (MI) can be evaluated by cardiac magnetic resonance (CMR). Purpose To explore an association between aortic stiffness and epicardial as well as paracardial fat volume (EFV and ParaFV, respectively) in hypertensive patients and to relate the results to the presence of DM and MI. Material and Methods A total of 156 hypertensive and 20 non-hypertensive participants were examined at 1.5 Tesla. A 2D-velocity-encoded sequence was acquired to assess aortic pulse wave velocity (PWV in m/s) as a measure of aortic stiffness. A 3D-Dixon sequence was used to determine EFV and ParaFV. Results PWV correlated with EFV (R = 0.474; P < 0.001), but not with ParaFV. Fat volumes (in mL/m2) and PWV were lower in non-hypertensive controls compared to hypertensive patients. EFV and PWV were significantly higher in diabetic hypertensive patients without MI (n = 19; PWV: 10.4 ± 2.9; EFV: 92.5 ± 19.3) compared to hypertension-only patients (n = 84 [no DM or MI]; EFV: 64.8 ± 25.1, PWV: 9.0 ± 2.6; P < 0.05). Logistic regression analysis showed a significant association between the presence of a MI and a higher EFV ( P < 0.05), but not with PWV ( P = 0.060) or ParaFV ( P = 0.375). Conclusion A relationship between aortic stiffness and EFV was found in hypertensive patients. Both were increased in the presence of DM; however, only EFV was increased in the presence of MI. This may relate to the PWV lowering effect of the antihypertensive medication used by hypertensive patients and underscores the benefit of EFV assessment in this regard.

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3D-Dixon cardiac magnetic resonance detects an increased epicardial fat volume in hypertensive men with myocardial infarction

European Journal of Radiology ◽

10.1016/j.ejrad.2016.02.016 ◽

2016 ◽

Vol 85 (5) ◽

pp. 936-942 ◽

Cited By ~ 13

Author(s):

Rami Homsi ◽

Alois M. Sprinkart ◽

Juergen Gieseke ◽

Seyrani Yuecel ◽

Michael Meier-Schroers ◽

...

Keyword(s):

Myocardial Infarction ◽

Cardiac Magnetic Resonance ◽

Magnetic Resonance ◽

Epicardial Fat ◽

Epicardial Fat Volume ◽

Fat Volume

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Ethnic differences in coronary plaque and epicardial fat volume quantified using computed tomography

The International Journal of Cardiovascular Imaging ◽

10.1007/s10554-016-0982-1 ◽

2016 ◽

Vol 33 (2) ◽

pp. 241-249 ◽

Cited By ~ 8

Author(s):

Daniel B. Adams ◽

Om Narayan ◽

Ravi Kiran Munnur ◽

James D. Cameron ◽

Dennis T. L. Wong ◽

...

Keyword(s):

Computed Tomography ◽

Ethnic Differences ◽

Coronary Plaque ◽

Epicardial Fat ◽

Epicardial Fat Volume ◽

Fat Volume

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Micrornas As Circulating Biomarkers Of Epicardial Fat Volume: A Multidetector Computed Tomography Study

Atherosclerosis ◽

10.1016/j.atherosclerosis.2019.06.204 ◽

2019 ◽

Vol 287 ◽

pp. e71-e72

Author(s):

D. De Gonzalo-Calvo ◽

D. Vilades ◽

P. Martínez-Camblor ◽

A. Vea ◽

L. Nasarre ◽

...

Keyword(s):

Computed Tomography ◽

Multidetector Computed Tomography ◽

Epicardial Fat ◽

Circulating Biomarkers ◽

Epicardial Fat Volume ◽

Fat Volume

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Type of Coronary Artery Plaque in Relation to Epicardial Fat Volume in Coronary Heart Disease Patients: A Cardiac Computed Tomography Scan Study

Althea Medical Journal ◽

10.15850/amj.v7n3.1904 ◽

2020 ◽

pp. 142-148

Author(s):

Iman Imaduddin Robandi ◽

Ristaniah D. Soetikno ◽

Dian Komala Dewi

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Coronary Artery ◽

Ct Scan ◽

Cardiac Computed Tomography ◽

Epicardial Fat ◽

High Morbidity ◽

Coronary Artery Plaque ◽

Epicardial Fat Volume ◽

Fat Volume

Background: Coronary heart disease (CHD) is a disease that raises public health concerns due to its high morbidity and mortality rates. Anatomically, epicardial fat is located around the heart and coronary system, making it important in the development of coronary atherosclerosis. This study aimed to explore the relationship between epicardial fat volume (EFV) and the type of coronary artery plaque by using Cardiac Computed Tomoghraphy (CT)-Scan. Methods: This was a cross-sectional observational analytic study on patients diagnosed with CHD aged > 20 years who had undergone cardiac CT-Scan at the Department of Radiology, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia between February and June 2019. Data collected from the CT-Scan were analyzed using the Chi-square test. Results: From 54 CHD patients, consisting of an equal number of male and female patients, with a majority of above 60 years old (31.5%), a correlation was identified between increased amount of EFV and mix and hard plaques in the right cirumflex artery (RCA) (p<0.026) and left circumflex (LCX) (p<0.038)On the left main(LM) and left anterior descending (LAD) arteries, no significant correlation was observed between EFV and the type of plaque (p>0.05). Conclusions: There is a significant relationship between the EFV value, EFV category, and the type of coronary artery plaque in CHD patients in RCA and LCX arteries. However, this correlation is not observed in LM and LAD arteries.

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