scholarly journals Complex tone stimulation may induce binaural diplacusis with low-tone hearing loss

PLoS ONE ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. e0210939
Author(s):  
Issei Ichimiya ◽  
Hiroko Ichimiya
Keyword(s):  
1994 ◽  
Vol 120 (5) ◽  
pp. 532-535 ◽  
Author(s):  
T. Yamasoba ◽  
S. Kikuchi ◽  
M. Sugasawa ◽  
M. Yagi ◽  
T. Harada

2020 ◽  
pp. 014556132095250
Author(s):  
Diyan Chen ◽  
Zhujian Wang ◽  
Gaogan Jia ◽  
Huanyu Mao ◽  
Yusu Ni

Objective: Immunity is associated with acute low tone hearing loss. However, the exact pathophysiology of immunity-mediated acute low tone hearing loss remains unknown. In this study, we evaluated the presence, therapeutic effectiveness, and immunopathological mechanisms of anti-endothelial cell autoantibodies (AECEs) in patients with acute low-frequency hearing loss. Material and Methods: Forty-nine patients who were treated as inpatients having acute low-frequency hearing loss and additional symptoms, such as ear fullness, tinnitus, dizziness, or hyperacusis, were enrolled in this study. Serum samples from these patients were collected for laboratory serum autoimmunity detection, including AECAs, antinuclear antibodies, immunoglobulin, and circular immune complex. Therapeutic responses to combination therapy in short-term outcome and serum cytokine levels were compared between AECA-positive and AECA-negative patients. Results: Anti-endothelial cell autoantibodies–positive patients tended to show significantly less response to standard therapy compared with AECAs controls ( P < .05). Moreover, some serum cytokine levels elevated in both AECAs− and AECAs+ groups. Positive ratio of interleukin-8 and concentrations of macrophage inflammatory protein-1α were found higher in AECAs+ groups ( P < .05). Conclusion: The results supported that AECAs might wield influence on the short-term outcome of acute low-tone hearing loss (ALHL) treatment. Furthermore, AECA-mediated acute low-frequency hearing loss possibly involved dysregulation of inflammation process and release of cytokines.


1989 ◽  
Vol 82 (4) ◽  
pp. 529-535 ◽  
Author(s):  
Keiichi Ichimura ◽  
Toshiaki Ikeda ◽  
Niro Tayama
Keyword(s):  

2007 ◽  
Vol 100 (10) ◽  
pp. 793-800 ◽  
Author(s):  
Shun-ichi Imamura ◽  
Masanori Miyata ◽  
Akihito Mizukoshi ◽  
Keisuke Masuyama
Keyword(s):  

1994 ◽  
Vol 37 (2) ◽  
pp. 87-91 ◽  
Author(s):  
Miyuki Ishikawa ◽  
Hideya Oi ◽  
Shinsuke Ueda ◽  
Shin Aso ◽  
Yukio Watanabe

2016 ◽  
Vol 21 (3) ◽  
pp. 132-140 ◽  
Author(s):  
Shinya Morita ◽  
Yuji Nakamaru ◽  
Keishi Fujiwara ◽  
Keiji Iizuka ◽  
Masayori Masuya ◽  
...  

Objectives: To evaluate the hearing outcomes of intratympanic steroid (ITS) treatment for patients with acute low-tone sensorineural hearing loss (ALHL) after failure of initial therapy and to investigate the recurrence and progression to definite Ménière's disease (MD) during a long-term follow-up. Methods: We retrospectively reviewed the medical records of 90 patients with refractory ALHL who were followed up for at least 1 year between January 2000 and April 2014. Patients who responded poorly to initial medical treatment received intratympanic dexamethasone injections (ITS group) or isosorbide administration for 4 weeks (diuretic group) as salvage treatment options according to their choice of management. The control group did not receive ITS or the diuretic, due to their refusal of both medical treatments. The hearing outcomes were evaluated 1 month, 1 year and 5 years after the completion of the second-line therapy, and the rates of recurrence and progression to MD were measured during a follow-up period of at least 1 year. Results: Twenty-seven patients in the ITS group, 39 patients in the diuretic group and 24 patients in the control group were enrolled. Of these, 12 patients in the ITS group, 15 patients in the diuretic group and 12 patients in the control group were followed up for over 5 years. We found that the recovery rates and the audiometric functional values after 1 month and 1 year in the ITS group were significantly higher than those in the diuretic and control groups. However, there were no significant differences in the recovery rates or the audiometric functional values after 5 years, or in the rates of recurrence and progression to MD between the groups. Conclusions: Salvage ITS therapy can provide a relatively good short-term hearing outcome for ALHL patients who have persistent hearing loss despite conventional treatment. However, both recurrence and progression to MD after treatment were observed in some patients during the long-term follow-up.


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