Genotype distribution of cervical HPV among Caribbean women in a population-based study in Martinique: The DEPIPAPUFR study

The Caribbean ranks seventh among the world regions most affected by cervical cancer. HPV-prevalence and genotype distributions also differ from regions. Knowledge of HPV genotype profiles is important for patients care and HPV vaccination implementation. The objective of this study was to describe HPV genotype distribution and risk factors in a population-based cohort of women in Martinique. In this study, 1312 women were included and underwent cervical cancer screening with successful sample collection between 2009 and 2014. Sociodemographic and clinical variables were recorded. Cytological examination of cervical vaginal smear was performed and classified(Bethesda). Detection of HPV DNA was performed with the PapilloCheck© Kit from Greiner Bio-one. Genotypes were analyzed for18 high-risk HPV (hrHPV) and 6low-risk HPV(lrHPV) types. A total of 1075 women were included with a mean age of 49.1±10.5 years. HPV prevalence was 27.6% (297/1075) with 19.4% (209/1075) women with only hrHPV, 5.3% (57/1075) with only lrHPV. Multiple infections (hrHPV/lrHPV) were detected in 31/240 cases of hrHPV (12.9%). A total of 353 hrHPV genotypes were analyzed; the most common HPV types were HPV51 (11.0%), HPV68 (10.8%), HPV53 (9.1%) and HPV 52 (7.1%). HPV16 and HPV18 represented respectively 4.8% and 4.0% of hrHPV genotypes. Abnormal cytology was observed in 34 cases (3.2%), with 14 ASCUS (1.3%), 10 LSIL (0.9%), 5 HSIL (0.5%), 3 ASC-H (0.3%) and 2 AGC (0.2%). Fifteen (44.1%) were hrHPV and 4 (14.7%) lrHPV; 7 cases of hrPHV were in the age-group 25–34 years. Among 1041cases of normal cytology, 225 had positive hrHPV detection (21.6%). This is the first population-based study of HPV profiles in our country, and we found a high prevalence of hrHPV. The most common genotypes were HPV51, 68, 53. These results could serve for cancer vaccination strategies and HPV surveillance in Martinique.

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Age factor and implication of human papillomavirus type-specific prevalence in women with normal cervical cytology

Epidemiology and Infection ◽

10.1017/s0950268811000720 ◽

2011 ◽

Vol 140 (3) ◽

pp. 466-473 ◽

Cited By ~ 6

Author(s):

C. H. LAI ◽

A. CHAO ◽

C. J. CHANG ◽

C. C. HUANG ◽

L. C. WANG ◽

...

Keyword(s):

Human Papillomavirus ◽

Hormone Replacement ◽

Menopausal Status ◽

Hpv Infection ◽

Population Based ◽

Cervical Cytology ◽

Genotype Distribution ◽

Abnormal Cytology ◽

Normal Cytology ◽

Normal Cervical Cytology

SUMMARYThe prevalence and genotype distribution of human papillomavirus (HPV) infection in women with normal cervical cytology varies widely according to the population studied. Two non-overlapping population-based cohort studies of women aged ⩾30 years for the periods 2008–2009 (n=5026) and 2004–2005 (n=10 014) were analysed. The prevalence rate of HPV was 11·0% (95% CI 10·5–11·6). HPV infection was significantly associated with age, menopausal status, and inversely associated with hormone replacement therapy. There was an increasing trend of α3/α15, α5/α6, and multiple HPV infections with increasing age. The five most common types were HPV52, 18, 53, 58 and 70, while HPV16, 31, 33 ranked 21st, 25th, and 16th, respectively, in the merged cohort with normal cytology (n=14 724). HPV16, 31, and 33 were significantly associated with abnormal cytology, which could have resulted in their rarity in the total merged cohort (n=15 040).

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HPV prevalence and type-distribution in cervical cancer and premalignant lesions of the cervix: A population-based study from Northern Ireland

Journal of Medical Virology ◽

10.1002/jmv.24447 ◽

2016 ◽

Vol 88 (7) ◽

pp. 1262-1270 ◽

Cited By ~ 13

Author(s):

Lesley A. Anderson ◽

Michael A. O'Rorke ◽

Robbie Wilson ◽

Jackie Jamison ◽

Anna T. Gavin ◽

...

Keyword(s):

Cervical Cancer ◽

Northern Ireland ◽

Population Based ◽

Premalignant Lesions ◽

Population Based Study ◽

Type Distribution ◽

Hpv Prevalence

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Cervical Cancer in Sub-Saharan Africa – a multinational population-based study on treatment guideline adherence

10.1055/s-0039-1692081 ◽

2019 ◽

Author(s):

M Griesel ◽

DM Parkin ◽

C Thomssen ◽

EJ Kantelhardt

Keyword(s):

Cervical Cancer ◽

Guideline Adherence ◽

Treatment Guideline ◽

Population Based ◽

Sub Saharan Africa ◽

Population Based Study ◽

Sub Saharan

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Frequent high-risk HPV co-infections excluding types 16 or 18 in cervical neoplasia in Guadeloupe

BMC Cancer ◽

10.1186/s12885-021-07940-3 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Stanie Gaete ◽

Aviane Auguste ◽

Bernard Bhakkan ◽

Jessica Peruvien ◽

Cecile Herrmann-Storck ◽

...

Keyword(s):

Cervical Cancer ◽

Invasive Cervical Cancer ◽

Population Based ◽

Multiple Infections ◽

French Caribbean ◽

Papilloma Virus ◽

Hpv Genotyping ◽

Hpv Status ◽

Hpv Genotypes ◽

High Risk Hpv

Abstract Background Cervical cancer is the fourth cancer worldwide. The Human Papilloma Virus is responsible for 99% of the cases but the distribution of its genotypes varies among populations. We aimed to identify HPV genotypes distribution in women with grade 2/3 cervical intraepithelial dysplasia or invasive cervical cancer in Guadeloupe, a French Caribbean territory with a population mainly of African descent. Methods We used paraffin-embedded tumors for viral DNA extraction from women diagnosed between 2014 and 2016 and identified by the population-based cancer registry. The HPV Genotyping was performed with the InnoLIPA HPV Genotyping Extra kit®. Results Overall, 213 samples out of the 321 eligible records were analyzed. The HPV status was positive for 94% of the cases. The five most common oncogenic HPV genotypes were HPV31 (47%), HPV33 (38%), HPV16 (32%), HPV44 (31%) and HPV26 (28%). HPV18 was found in only in 5% of the cases. Among the studied cases, 94% had multiple infections. More than 60% of single infections were HPV16-related, accounting for 35% of HPV16 infections. Conclusions These results show a different distribution of oncogenic HPVs in Guadeloupe with “31 > 33 > 16” and a high frequency of multiple infections. Despite a lower coverage, the nine-valent vaccine is nevertheless adequate.

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