scholarly journals Helicobacter pylori Exploits a Unique Repertoire of Type IV Secretion System Components for Pilus Assembly at the Bacteria-Host Cell Interface

2011 ◽  
Vol 7 (9) ◽  
pp. e1002237 ◽  
Author(s):  
Carrie L. Shaffer ◽  
Jennifer A. Gaddy ◽  
John T. Loh ◽  
Elizabeth M. Johnson ◽  
Salisha Hill ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Host Cell ◽  
Secretion System ◽  
Type Iv Secretion ◽  
Type Iv Secretion System ◽  
Type Iv ◽  
System Components ◽  
Cell Interface ◽  
Pilus Assembly

scholarly journals Genetic variants of Helicobacter pylori type IV secretion system components CagL and CagI and their association with clinical outcomes

Gut Pathogens ◽  
2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Hirofumi Ogawa ◽  
Akira Iwamoto ◽  
Toshihito Tanahashi ◽  
Rina Okada ◽  
Koji Yamamoto ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Clinical Outcomes ◽  
Genetic Variants ◽  
Secretion System ◽  
Type Iv Secretion ◽  
Type Iv Secretion System ◽  
Type Iv ◽  
System Components

scholarly journals Analysis of Cell Type-Specific Responses Mediated by the Type IV Secretion System of Helicobacter pylori

2005 ◽  
Vol 73 (8) ◽  
pp. 4643-4652 ◽  
Author(s):  
Bianca Bauer ◽  
Stefan Moese ◽  
Sina Bartfeld ◽  
Thomas F. Meyer ◽  
Matthias Selbach
Keyword(s):  
Helicobacter Pylori ◽  
Host Cell ◽  
Secretion System ◽  
Type Iv Secretion ◽  
Type Iv Secretion System ◽  
Type Iv ◽  
Host Cell Proteins ◽  
Mammalian Cell Lines ◽  
Host Cell Factors ◽  
H Pylori

ABSTRACT Helicobacter pylori persistently infects the human stomach and can cause gastritis, gastric ulceration, and gastric cancer. The type IV secretion system (TFSS) of virulent H. pylori strains translocates the CagA protein, inducing the dephosphorylation of host cell proteins and leading to changes in the morphology or shape of AGS gastric epithelial cells. Furthermore, the TFSS is involved in the induction of proinflammatory cytokines. While the H. pylori genes required for TFSS function have been investigated systematically, little is known about possible host cell factors involved. We infected 19 different mammalian cell lines individually with H. pylori and analyzed CagA translocation, dephosphorylation of host cell proteins, chemokine secretion (interleukin-8 and macrophage inflammatory protein 2), and changes in cellular phenotypes. Our results demonstrate that not only bacterial but also host cell factors determine the cellular response to infection. The identification of such unknown host cell factors will add to our understanding of host-pathogen interactions and might help in the development of new therapeutic strategies.

High prevalence of functional type IV secretion system for CagA protein in Japanese clinical Helicobacter pylori

2001 ◽  
Vol 120 (5) ◽  
pp. A652-A653
Author(s):  
Y HIRATA ◽  
S MAEDA ◽  
Y MITUNO ◽  
M AKANUMA ◽  
T KAWABE ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Secretion System ◽  
Type Iv Secretion ◽  
Type Iv Secretion System ◽  
Functional Type ◽  
Caga Protein ◽  
Type Iv ◽  
High Prevalence

scholarly journals 814 – Helicobacter Pylori Induces Aberrant Lrig1 Stem Cell Activity Within the Stomach in a Cag Type Iv Secretion System-Dependent Manner

2019 ◽  
Vol 156 (6) ◽  
pp. S-171-S-172 ◽  
Author(s):  
Lydia Wroblewski ◽  
Eunyoung Choi ◽  
Christine Petersen ◽  
Alberto Delgado ◽  
M. Blanca Piazuelo ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Stem Cell ◽  
Cell Activity ◽  
Secretion System ◽  
Type Iv Secretion ◽  
Type Iv Secretion System ◽  
Dependent Manner ◽  
Type Iv ◽  
Stem Cell Activity
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