Retroviral Delivery of ECM Genes to Cells

2003 ◽  
pp. 197-208
Author(s):  
Kyonggeun Yoon ◽  
Vitali Alexeev
Keyword(s):  
Retroviral Delivery

Reduction of hypertrophic scar via retroviral delivery of a dominant negative TGF-β receptor II

2007 ◽  
Vol 60 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Russell R. Reid ◽  
Nakshatra Roy ◽  
Jon E. Mogford ◽  
Hannah Zimmerman ◽  
Chung Lee ◽  
...  
Keyword(s):  
Hypertrophic Scar ◽  
Dominant Negative ◽  
Β Receptor ◽  
Retroviral Delivery

scholarly journals Stable silencing of the glucocorticoid receptor in myelin-specific T effector cells by retroviral delivery of shRNA: Insight into neuroinflammatory disease

2009 ◽  
Vol 39 (9) ◽  
pp. 2361-2370 ◽  
Author(s):  
Denise Tischner ◽  
Jens van den Brandt ◽  
Andreas Weishaupt ◽  
Fred Lühder ◽  
Marco J. Herold ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Effector Cells ◽  
T Effector Cells ◽  
Neuroinflammatory Disease ◽  
Retroviral Delivery ◽  
Insight Into

scholarly journals Differential αv integrin–mediated Ras-ERK signaling during two pathways of angiogenesis

2003 ◽  
Vol 162 (5) ◽  
pp. 933-943 ◽  
Author(s):  
John D. Hood ◽  
Ricardo Frausto ◽  
William B. Kiosses ◽  
Martin A. Schwartz ◽  
David A. Cheresh
Keyword(s):  
Chorioallantoic Membrane ◽  
Integrin Αvβ3 ◽  
Erk Signaling ◽  
Erk Pathway ◽  
Chick Chorioallantoic Membrane ◽  
Endothelial Cell Survival ◽  
Extracellular Signal ◽  
P21 Activated Kinase ◽  
Erk Activity ◽  
Retroviral Delivery

Antagonists of αvβ3 and αvβ5 disrupt angiogenesis in response to bFGF and VEGF, respectively. Here, we show that these αv integrins differentially contribute to sustained Ras-extracellular signal–related kinase (Ras-ERK) signaling in blood vessels, a requirement for endothelial cell survival and angiogenesis. Inhibition of FAK or αvβ5 disrupted VEGF-mediated Ras and c-Raf activity on the chick chorioallantoic membrane, whereas blockade of FAK or integrin αvβ3 had no effect on bFGF-mediated Ras activity, but did suppress c-Raf activation. Furthermore, retroviral delivery of active Ras or c-Raf promoted ERK activity and angiogenesis, which anti-αvβ5 blocked upstream of Ras, whereas anti-αvβ3 blocked downstream of Ras, but upstream of c-Raf. The activation of c-Raf by bFGF/αvβ3 not only depended on FAK, but also required p21-activated kinase-dependent phosphorylation of serine 338 on c-Raf, whereas VEGF-mediated c-Raf phosphorylation/activation depended on Src, but not Pak. Thus, integrins αvβ3 and αvβ5 differentially regulate the Ras-ERK pathway, accounting for distinct vascular responses during two pathways of angiogenesis.

Retroviral Delivery of DNA into the Livers of Transgenic Mice Bearing Premalignant and Malignant Hepatocellular Carcinomas

1994 ◽  
Vol 5 (7) ◽  
pp. 845-852 ◽  
Author(s):  
Osamu Kimura ◽  
Yumi Yamaguchi ◽  
Kerry B. Gunning ◽  
Larry D. Teeter ◽  
Farah Husain ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Hepatocellular Carcinomas ◽  
Retroviral Delivery
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