Modulation of Nuclear Factor-κB by Human T Cell Leukemia Virus Type 1 Tax Protein: Implications for Oncogenesis and Inflammation

2006 ◽  
Vol 34 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Jean-Marie Peloponese ◽  
Man Lung Yeung ◽  
Kuan-Teh Jeang
2008 ◽  
Vol 99 (5) ◽  
pp. 872-878 ◽  
Author(s):  
Takayuki Nitta ◽  
Masakazu Tanaka ◽  
Binlian Sun ◽  
Eiji Sugihara ◽  
Mako Kimura ◽  
...  

1998 ◽  
Vol 72 (5) ◽  
pp. 3958-3964 ◽  
Author(s):  
Akira Tanimura ◽  
Shingo Dan ◽  
Mitsuaki Yoshida

ABSTRACT The expression of human T-cell leukemia virus type 1 (HTLV-1) is activated by interaction of a viral transactivator protein, Tax, and cellular transcription factor, CREB (cyclic AMP response element binding protein), which bind to a 21-bp enhancer in the long terminal repeats (LTR). THP (Tax-helping protein) was previously determined to enhance the transactivation by Tax protein. Here we report novel forms of the human homolog of a member of the Gli oncogene family, Gli2 (also termed Gli2/THP), an extended form of a zinc finger protein, THP, which was described previously. Four possible isoforms (hGli2 α, β, γ, and δ) are formed by combinations of two independent alternative splicings, and all the isoforms could bind to a DNA motif, TRE2S, in the LTR. The longer isoforms, α and β, were abundantly expressed in various cell lines including HTLV-1-infected T-cell lines. Fusion proteins of the hGli2 isoforms with the DNA-binding domain of Gal4 activated transcription when the reporter contained a Gal4-binding site and one copy of the 21-bp sequence, to which CREB binds. This activation was observed only in the presence of Tax. The 21-bp sequence in the reporter was also essential for the activation. These results suggest that simultaneous binding of hGli2 and CREB to the respective sites in the reporter seems to be critical for Tax protein to activate transcription. Consequently, it is probable that the LTR can be regulated by two independent signals through hGli2 and CREB, since the LTR contains the 21-bp and TRE2S sequences in the vicinity.


Virology ◽  
1998 ◽  
Vol 241 (2) ◽  
pp. 298-303 ◽  
Author(s):  
Masaaki Arai ◽  
Takashi Ohashi ◽  
Tomonori Tsukahara ◽  
Tsutomu Murakami ◽  
Toshiyuki Hori ◽  
...  

2010 ◽  
Vol 34 (6) ◽  
pp. 763-768 ◽  
Author(s):  
Jing Zhang ◽  
Osamu Yamada ◽  
Yoshihisa Matsushita ◽  
Haorile Chagan-Yasutan ◽  
Toshio Hattori

Virology ◽  
2011 ◽  
Vol 413 (2) ◽  
pp. 244-252 ◽  
Author(s):  
Jing Zhang ◽  
Osamu Yamada ◽  
Shinya Kida ◽  
Yoshihisa Matsushita ◽  
Shoji Yamaoka ◽  
...  

Virology ◽  
2002 ◽  
Vol 302 (1) ◽  
pp. 132-143 ◽  
Author(s):  
Toshiyuki Takahashi ◽  
Masaya Higuchi ◽  
Masaya Fukushi ◽  
Masayasu Oie ◽  
Masaaki Ito ◽  
...  

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