Acetylcholinesterase: A Multifaceted Target for Structure-Based Drug Design of Anticholinesterase Agents for the Treatment of Alzheimer's Disease

2003 ◽  
Vol 20 (3) ◽  
pp. 369-384 ◽  
Author(s):  
Harry M. Greenblatt ◽  
Hay Dvir ◽  
Israel Silman ◽  
Joel L. Sussman
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Design ◽  
Structure Based Drug Design ◽  
Anticholinesterase Agents

Phytochemicals for drug discovery in Alzheimer’s disease: In silico Advances

2020 ◽  
Vol 26 ◽  
Author(s):  
Smriti Sharma ◽  
Vinayak Bhatia
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Design ◽  
In Silico ◽  
Drug Targets ◽  
Development Process ◽  
Phytochemical Analysis ◽  
Computational Drug Design ◽  
Novel Drugs ◽  
Game Changer

: The search for novel drugs that can prevent or control Alzheimer’s disease has attracted lot of attention from researchers across the globe. Phytochemicals are increasingly being used to provide scaffolds to design drugs for AD. In silico techniques, have proven to be a game-changer in this drug design and development process. In this review, the authors have focussed on current advances in the field of in silico medicine, applied to phytochemicals, to discover novel drugs to prevent or cure AD. After giving a brief context of the etiology and available drug targets for AD, authors have discussed the latest advances and techniques in computational drug design of AD from phytochemicals. Some of the prototypical studies in this area are discussed in detail. In silico phytochemical analysis is a tool of choice for researchers all across the globe and helps integrate chemical biology with drug design.

scholarly journals Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-β aggregation

2017 ◽  
Vol 9 (10) ◽  
pp. 953-963 ◽  
Author(s):  
Elena Simoni ◽  
Manuela Bartolini ◽  
Izuddin F Abu ◽  
Alix Blockley ◽  
Cecilia Gotti ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Design ◽  
Amyloid Β ◽  
Design Strategy ◽  
Cholinergic Transmission ◽  
Disease Focus

Secretases as targets for drug design in Alzheimer’s disease

2002 ◽  
Vol 32 (1) ◽  
pp. 60-68 ◽  
Author(s):  
J. V. R. B. Hendriksen ◽  
H. S. L. M. Nottet ◽  
H. A. Smits
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Design

scholarly journals Lifting the veil on amyloid drug design

eLife ◽  
2013 ◽  
Vol 2 ◽  
Author(s):  
Kathryn E Tiller ◽  
Peter M Tessier
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
High Resolution ◽  
Drug Design ◽  
Computational Methods ◽  
Amyloid Fibrils ◽  
Toxic Species ◽  
The Veil

High resolution structures and computational methods have been used to identify compounds that prevent amyloid fibrils associated with Alzheimer’s disease from dissociating into toxic species.

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