Receptor Protein Tyrosine Phosphatase From Stem Cells to Mature Glial Cells of the Central Nervous System

2006 ◽  
Vol 29 (3) ◽  
pp. 241-256 ◽  
Author(s):  
Smaragda Lamprianou ◽  
Sheila Harroch
Keyword(s):  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Glial Cells ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Protein ◽  
Protein Tyrosine ◽  
Receptor Protein Tyrosine Phosphatase ◽  
The Central Nervous System

Expression of receptor protein tyrosine phosphatase δ, PTPδ, in mouse central nervous system

2016 ◽  
Vol 1642 ◽  
pp. 244-254 ◽  
Author(s):  
Maria Shishikura ◽  
Fumio Nakamura ◽  
Naoya Yamashita ◽  
Noriko Uetani ◽  
Yoichiro Iwakura ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Receptor Protein ◽  
Protein Tyrosine ◽  
Receptor Protein Tyrosine Phosphatase ◽  
Mouse Central Nervous System

The role of receptor protein tyrosine phosphatase α in neuronal differentiation of embryonic stem cells

1996 ◽  
Vol 91 (2) ◽  
pp. 304-307 ◽  
Author(s):  
Wouter G. van Inzen ◽  
Maikel P. Peppelenbosch ◽  
Maria W.M. van den Brand ◽  
Leon G.J. Tertoolen ◽  
Siegfried de Laat
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Neuronal Differentiation ◽  
Protein Tyrosine Phosphatase ◽  
Tyrosine Phosphatase ◽  
Embryonic Stem ◽  
Receptor Protein ◽  
Protein Tyrosine ◽  
Receptor Protein Tyrosine Phosphatase

scholarly journals Insight into the Role of the STriatal-Enriched Protein Tyrosine Phosphatase (STEP) in A2A Receptor-Mediated Effects in the Central Nervous System

2021 ◽  
Vol 12 ◽  
Author(s):  
Maria Rosaria Domenici ◽  
Cinzia Mallozzi ◽  
Rita Pepponi ◽  
Ida Casella ◽  
Valentina Chiodi ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Protein Tyrosine Phosphatase ◽  
Motor Behavior ◽  
Tyrosine Phosphatase ◽  
Neuroblastoma Cell ◽  
Rat Striatum ◽  
Protein Tyrosine ◽  
Neuropsychiatric Diseases ◽  
The Central Nervous System

The STriatal-Enriched protein tyrosine phosphatase STEP is a brain-specific tyrosine phosphatase that plays a pivotal role in the mechanisms of learning and memory, and it has been demonstrated to be involved in several neuropsychiatric diseases. Recently, we found a functional interaction between STEP and adenosine A2A receptor (A2AR), a subtype of the adenosine receptor family widely expressed in the central nervous system, where it regulates motor behavior and cognition, and plays a role in cell survival and neurodegeneration. Specifically, we demonstrated the involvement of STEP in A2AR-mediated cocaine effects in the striatum and, more recently, we found that in the rat striatum and hippocampus, as well as in a neuroblastoma cell line, the overexpression of the A2AR, or its stimulation, results in an increase in STEP activity. In the present article we will discuss the functional implication of this interaction, trying to examine the possible mechanisms involved in this relation between STEP and A2ARs.

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