:
Schiff bases of isatin were synthesized by reacting isatin with substituted aromatic amines and were characterized by UV-Visible, 1HNMR, 13CNMR, IR, and microanalytical data. All the synthesized isatin Schiff bases were screened in vitro against wheat pathogenic fungi Bipolaris sorokiniana, Alternaria triticina using spore inhibition technique and brinjal parasite- Meloidogyne incognita by egg hatch inhibition and J2 mortality. The in vitro study and docking simulation studies revealed that the 3-(2,4,5-trichlorophenylimino)indolin-2-one 6f and 3-(2,4-dinitrophenylimino)indolin-2-one 6c substituted with tri-halogen and dinitro electron-withdrawing groups were found to be promising antipathogenic candidates. The possible binding interactions of tested compounds with Aspartyl protease and Acetylcholine binding proteins were analyzed through molecular docking.