scholarly journals Erectile dysfunction and the biochemical/molecular/ regulation of human penile arteries

2019 ◽  
Author(s):  
István Előd Király
Keyword(s):  
Erectile Dysfunction ◽  
Essential Role ◽  
Enzyme Inhibitors ◽  
Molecular Regulation ◽  
Non Invasive ◽  
Vascular Type ◽  
Resistance Vessels ◽  
Flow Mediated Vasodilation ◽  
Invasive Diagnostic Procedure ◽  
Penile Arteries

1.Flow mediated vasodilation as a new, non-invasive diagnostic procedure in the examination of vascular type erectile dysfunction. 2.CNP has a strong vasodilatation effect on human resistance vessels in the presence of NO synthase and cyclooxygenase enzyme inhibitors 3.That relaxation demonstrates a similar characteristics as an EDHF released by Ach 4.CNP has a smooth muscle cells hyperpolarization effect similar to Ach 5.Our examinations prove CNP is an EDHF in human penile resistance vessels which plays an essential role in the reduction of vessel tone supporting erection. 6.CNP or its similar compounds may be successful in the treatment of erectile dysfunction. 7.NO and EDHF take part in the endothelium dependence relaxation human penile intracavernosus arteries. 8.BKC channels play an essential role in the establishment of the effect enduced by both of NO and EDHF 9.During our examination the opening compounds of BKC channels are assumed to be effective in the treatment of disregulation of penile arteries. 10.The Hungarian implementation of female to male sexual reassignment operation Development of the surgical technique in our Department of Urology has lead to better functional and esthetical results. These modifications are the following -The turned down u-shape perineal incision was exchanged by median sagittal incision-The expert preparation of neurovascular bundle -Reaching clitoral orgasm a greater part of the glans is used at the creation of clitoris, one part of it is deepithelialized and it is sunk under the skin. The fixing sutures of the neo clitoris is placed into foreskin to avoid circular damage.

Non-invasive positive airway pressure therapy for improving erectile dysfunction in men with obstructive sleep apnoea

2021 ◽  
Vol 2021 (9) ◽  
Author(s):  
Frederico T Barbosa ◽  
Michele P Silva ◽  
Luís Eduardo S Fontes ◽  
Daniela V Pachito ◽  
Tamara Melnik ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Obstructive Sleep Apnoea ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Sleep Apnoea ◽  
Pressure Therapy ◽  
Positive Airway Pressure Therapy ◽  
Non Invasive ◽  
Obstructive Sleep

scholarly journals Proteins of Excitable Membranes

1969 ◽  
Vol 54 (1) ◽  
pp. 187-224 ◽  
Author(s):  
David Nachmansohn
Keyword(s):  
Electrical Activity ◽  
Essential Role ◽  
Enzyme Inhibitors ◽  
Specific Protein ◽  
Receptor Protein ◽  
Excitable Membranes ◽  
Protein Properties ◽  
Ion Movements ◽  
Hydrolysis Of

Excitable membranes have the special ability of changing rapidly and reversibly their permeability to ions, thereby controlling the ion movements that carry the electric currents propagating nerve impulses. Acetylcholine (ACh) is the specific signal which is released by excitation and is recognized by a specific protein, the ACh-receptor; it induces a conformational change, triggering off a sequence of reactions resulting in increased permeability. The hydrolysis of ACh by ACh-esterase restores the barrier to ions. The enzymes hydrolyzing and forming ACh and the receptor protein are present in the various types of excitable membranes. Properties of the two proteins directly associated with electrical activity, receptor and esterase, will be described in this and subsequent lectures. ACh-esterase has been shown to be located within the excitable membranes. Potent enzyme inhibitors block electrical activity demonstrating the essential role in this function. The enzyme has been recently crystallized and some protein properties will be described. The monocellular electroplax preparation offers a uniquely favorable material for analyzing the properties of the ACh-receptor and its relation to function. The essential role of the receptor in electrical activity has been demonstrated with specific receptor inhibitors. Recent data show the basically similar role of ACh in the axonal and junctional membranes; the differences of electrical events and pharmacological actions are due to variations of shape, structural organization, and environment.

scholarly journals Ca2+-activated K+channel (KCa) stimulation improves relaxant capacity of PDE5 inhibitors in human penile arteries and recovers the reduced efficacy of PDE5 inhibition in diabetic erectile dysfunction

2013 ◽  
Vol 169 (2) ◽  
pp. 449-461 ◽  
Author(s):  
R González-Corrochano ◽  
JM La Fuente ◽  
P Cuevas ◽  
A Fernández ◽  
MX Chen ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
K Channel ◽  
Pde5 Inhibitors ◽  
Pde5 Inhibition ◽  
Penile Arteries

Diabetes Exacerbates the Functional Deficiency of NO/cGMP Pathway Associated with Erectile Dysfunction in Human Corpus Cavernosum and Penile Arteries

2010 ◽  
Vol 7 (2) ◽  
pp. 758-768 ◽  
Author(s):  
Javier Angulo ◽  
Rocío González-Corrochano ◽  
Pedro Cuevas ◽  
Argentina Fernández ◽  
José M. La Fuente ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Corpus Cavernosum ◽  
Cgmp Pathway ◽  
Functional Deficiency ◽  
Penile Arteries

scholarly journals Correlation between lower urinary tract symptoms and objective measures of uroflowmetry

2017 ◽  
Vol 89 (2) ◽  
pp. 130
Author(s):  
Hakan Türk ◽  
Sıtkı Ün
Keyword(s):  
Erectile Dysfunction ◽  
Clinical Symptoms ◽  
Outlet Obstruction ◽  
Prostate Hyperplasia ◽  
Non Invasive ◽  
Included Patient ◽  
Study Results ◽  
Symptom Scores ◽  
Diagnostic Panel ◽  
Lower Urinary

Indroduction: Benign prostate hyperplasia (BPH) is the most commonly diagnosed benign adenoma which causes serious clinical symptoms by bladder outlet obstruction. BPH patients suffer from negative changes in their quality of life and restriction of their daily activities due to the disease symptoms. Our main objective in this study is to evaluate the relationship between BPH and LUTS as described by International Prostate Symptoms Score and objective non-invasive parameters related to BPH. Materials and methods: 238 Patients over 40 years with clinical BPH, LUTS and/or prostate volumes greater than 25 ml who presented to urology department were included in the study. All patients included in the study were subjected to a standardized diagnostic panel which included patient history, physical examination, biochemistry panels and urinalysis. Results: Results showed an increase in symptom scores with age. As symptom scores go from mild to severe; Qmax values showed a decrease meanwhile prostate volume, PSA and postvoid residue increased. Again, in terms of erectile dysfunction, erectile dysfunction complaints increased with increased IIEF symptom scores. When all these results were evaluated, a positive correlation was seen between uroflowmetry parameters with patient symptoms, PSA and IIEF scores. Conclusion: From our study results, we can conclude that uroflowmetry is a very useful tool in monitoring lower urinary system complaints.

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