scholarly journals DNA Binding Properties and Antibacterial Activity of Heterolyptic Transition Metal Complexes with 2,2-Bipyridyl and 2-Acetylthiophene Thiosemicarbazone

2019 ◽  
Vol 31 (9) ◽  
pp. 1905-1912 ◽  
Author(s):  
Kummara Srinivasulu ◽  
Katreddi Hussain Reddy ◽  
K. Anuja ◽  
D. Dhanalakshmi ◽  
Golla Ramesh
Keyword(s):  
Antibacterial Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Electrochemical Behaviour ◽  
Diffusion Method ◽  
Molecular Formula ◽  
Bacterial Strains ◽  
Cyclic Voltammetric ◽  
Binding Properties

Metal complexes having the composition M(Bipy)Cl2 (where, M = Cu(II), Ni(II) and Co(II); Bipy = 2,2-bipyridyl) are reacted with 2-acetylthiophene thiosemicarbazone (ATT) to produce heteroleptic transition metal complexes with molecular formula [M(Bipy)ATT]. The complexes are characterized by mass spectra, molar conductivity, infrared and electronic spectra. Electrochemical behaviour of these metal complexes was investigated by cyclic voltammetric studies. The metal complexes show quasi reversible cyclic voltammetric responses for the Cu(II)/Cu(I) couple. The binding properties of these complexes with calf-thymus DNA have been investigated by using absorption spectrophotometry. Metal complexes are screened for their antibacterial activity by using agar well diffusion method against pathogenic bacterial strains viz. Escherichia coli and Staphylococcus aureus. Antibacterial activity of the present complexes are comparable with the activity of ciprofloxacin. The Cu(Bipy)Cl2 complex inhibits bacteria more strongly than any other complex. The Ni(Bipy)ATT complex shows more activity than the parent complex, Ni(Bipy)Cl2.

Spectral Characterization, DNA Binding and Antibacterial Studies of Heterolyptic Metal Complexes with 2-Acetylthiophene-4-phenyl-3-thiosemicarbazone and 2,2′-Bipyridyl

2021 ◽  
Vol 6 (2) ◽  
pp. 84-91
Author(s):  
K. Srinivasulu ◽  
K. Hussain Reddy ◽  
D. Dhanalakshmi ◽  
K. Anuja ◽  
Y.B. Nagamani
Keyword(s):  
Dna Binding ◽  
Metal Complexes ◽  
Mass Spectra ◽  
Electrochemical Behaviour ◽  
Diffusion Method ◽  
Klebsiella Pneumonia ◽  
Molecular Formula ◽  
Bacterial Strains ◽  
Uv Visible ◽  
Dna Binding Properties

Heterolyptic metal complexes having the composition M(Bpy)Cl2 (where, M = Cu(II), Ni(II) and Co(II); Bpy = 2,2′-bipyridyl) were reacted with 2-acetylthiophene-4-phenyl-3-thiosemicarbazone (ATPT) to produce bivalent metal complexes with molecular formula M(Bpy)(ATPT)Cl·H2O. The complexes were characterized using physical (molar conductivity) and spectral (mass spectra, infrared and electronic spectroscopies) methods. Electrochemical behaviour of the complexes was revealed using cyclic voltammetry. The Cu(II)/Cu(I) couple complexes show a quasi-reversible cyclic voltammetric responses. The DNA binding properties of complexes were determined through absorption UV-visible spectrophotometry. Furthermore, the agar well diffusion method was used to screen the metal(II) complexes for their antibacterial activity against pathogenic bacterial strains, namely Gram negative strains such as Escherichia coli and Klebsiella pneumonia and Gram positve strains such as Staphylococcus aureus and Bacillus cereus. The synthesized Cu(Bpy)(ATPT)]Cl·H2O complex strongly inhibits bacteria compared with other complexes.

scholarly journals Studies on Antibacterial and Antifungal Activities and Minimum Inhibitory Concentrations of Mixed Ligand Transition Metal Complexes of Dibasic Acids as Primary and Heterocyclic Bases as Secondary Ligands

1970 ◽  
Vol 46 (3) ◽  
pp. 365-368 ◽  
Author(s):  
MA Akbor ◽  
MS Islam ◽  
N Akhter ◽  
S Ahmed ◽  
S Siraj
Keyword(s):  
Antifungal Activity ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Mixed Ligand ◽  
Diffusion Method ◽  
Antifungal Activities ◽  
Minimum Inhibitory Concentrations ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal

Mixed ligand (diphenic/ adipic as primary Ligand and quinoline / 8 - hydroxyquinoline as secondary) transition metal complexes of Cobalt (II), Cupper (II), Rhodium (III) and Platinum (IV) ions were synthesized and characterized. Their antibacterial activities against ten bacteria had been evaluated by the disc diffusion method,whilst their antifungal activities against two fungi had been also evaluated by the same method. Minimum inhibitory concentrations (MIC) had been evaluated against six bacteria. The MIC of the complexes against Shigella dysenteriae, Samonella typhi, Streptococcus-β-haemolyticus and Bacillus megaterium were 32 μg/ml; whilst Escherichia coli and Samonella typhi-A the MIC of Co (II) and Pt (IV) were 32μg/ml and those of Cu(II) and Rh(III) complexes were 64 μg/ml. It was found that Cobalt (II), Cupper (II) & Rhodium (III) complexes had pronounced antibacterial and antifungal activities. Platinum (IV) complex had moderate antibacterial and antifungal activity. These values indicate that these are active compounds. Key words: Mixed Ligand; Transition metal; Antimicrobial Activity; Antifungal Activity Minimum Inhibitory Concentrations (MIC) DOI: http://dx.doi.org/10.3329/bjsir.v46i3.9044 BJSIR 2011; 46(3): 365-368

Solid state π–π stacking and higher order dimensional crystal packing, reactivity, and electrochemical behaviour of salphenazine actinide and transition metal complexes

2016 ◽  
Vol 45 (36) ◽  
pp. 14243-14251 ◽  
Author(s):  
E. E. Hardy ◽  
M. A. Eddy ◽  
B. A. Maynard ◽  
A. E. V. Gorden
Keyword(s):  
Solid State ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Crystal Packing ◽  
Electrochemical Behaviour ◽  
Higher Order ◽  
State Behaviour ◽  
Dimensional Crystal ◽  
Synthesis Solution

Here, we describe and compare the synthesis, solution characterization, and solid-state behaviour of the salphenazine ligand and metal complexes.

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