Effect of intranasal mometasone furoate administered in children with coexisting allergic rhinitis and asthma towards asthma attacks and lung function

Background Allergic rhinitis and asthma are allergic manifestations in respiratory tract, which related each other. Intranasal corticosteroid is effective in allergic rhinitis and has benefits in decreasing lower airway reactivity.Objectives To evaluate effectiveness of intranasal mometasonefuroate towards asthma in children aged 6-18 years with coexisting allergic rhinitis and asthma.Methods A one group pretest-posttest ("before and after") study was conducted in Cipto Mangunkusumo Hospital from May to December 2008. Subjects were children aged 6-18 years, with moderate-severe intermittent or persistent allergic rhinitis with coexisting frequent episodic asthma or persistent asthma, and visited outpatient clinic of allergy immunology division or respirology division. Subjects were administered intranasal mometasone furoate 100 J-ig daily only for 8 weeks, without long term administration of oral and inhaled corticosteroid. Improvements in allergic rhinitis and asthma were evaluated using questionnaires and lung function tests.Results There were 35 subjects and four of them dropped outduring the study. There was >50% improvement in allergic rhinitis symptoms after 4 weeks of treatment (P<0.001). This improvement was associated with decreasing in frequency of asthma attack >50% after 8 weeks of treatment (P< 0.001). There was an insignificant improvement in FEY 1 (P=0.51). However, the evaluation of sinusitis was not performed in all subjects, thus may influence the results. During study, there were no side effects observed.Conclusions Intranasal mometasone furoate improves allergicrhinitis and decrease >50% of asthma symptoms, however it is not followed with significant improvement in lung function. No side effects are reported during 8 weeks use of intranasal mometasone furoate.

Download Full-text

Mometasone Furoate Dry Powder Inhaler Improves Lung Function in Patients With Persistent Asthma and Allergic Rhinitis History

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2005.12.375 ◽

2006 ◽

Vol 117 (2) ◽

pp. S94

Author(s):

E.J. Schenkel ◽

P. Stryszak ◽

H. Staudinger

Keyword(s):

Allergic Rhinitis ◽

Lung Function ◽

Dry Powder Inhaler ◽

Persistent Asthma ◽

Mometasone Furoate ◽

Dry Powder

Download Full-text

Effects of nonlinear error correction of measurements obtained by peak flowmeter using the Wright scale to assess asthma attack severity in children

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh0706310s ◽

2007 ◽

Vol 135 (5-6) ◽

pp. 310-316

Author(s):

Dragana Stamatovic ◽

Nada Bokan-Erdeljan

Keyword(s):

Objective Assessment ◽

Airflow Obstruction ◽

Persistent Asthma ◽

Percentage Error ◽

British Thoracic Society ◽

Asthma Attack ◽

Calibration Methods ◽

Measurement Results ◽

Before And After ◽

Severe Degree

Introduction: Monitoring of peak expiratory flow (PEF) is recommended in numerous guidelines for management of asthma. Improvements in calibration methods have demonstrated the inaccuracy of original Wright scale of peak flowmeter. A new standard, EN 13826 that was applied to peak flowmeter was adopted on 1st September 2004 by some European countries. Correction of PEF readings obtained with old type devices for measurement is possible by Dr M. Miller?s original predictive equation. Objective. Assessment of PEF correction effect on the interpretation of measurement results and management decisions. Method. In children with intermittent (35) or stable persistent asthma (75) aged 6-16 years, there were performed 8393 measurements of PEF by Vitalograph normal-range peak flowmeter with traditional Wright scale. Readings were expressed as percentage of individual best values (PB) before and after correction. The effect of correction was analyzed based on The British Thoracic Society guidelines for asthma attack treatment. Results. In general, correction reduced the values of PEF (p<0.01). The highest mean percentage error (20.70%) in the measured values was found in the subgroup in which PB ranged between 250 and 350 l/min. Nevertheless, the interpretation of PEF after the correction in this subgroup changed in only 2.41% of measurements. The lowest mean percentage error (15.72%), and, at the same time, the highest effect of correction on measurement results interpretation (in 22.65% readings) were in children with PB above 450 l/min. In 73 (66.37%) subjects, the correction changed the clinical interpretation of some values of PEF after correction. In 13 (11.8%) patients, some corrected values indicated the absence or a milder degree of airflow obstruction. In 27 (24.54%) children, more than 10%, and in 12 (10.93%), more than 20% of the corrected readings indicated a severe degree of asthma exacerbation that needed more aggressive treatment. Conclusion. Correction of PEF values obtained by peak flowmeters with traditional Wright scale shows a possibility of overtreatment in younger or short stature children and undertreatment in older or taller ones if we use old type of metres. The correction of peak flowmeter for non-linear error is a prerequisite in the application of asthma guidelines in PEF measurements. .

Download Full-text

Effects of Mometasone Furoate Administered Via a Dry Powder Inhaler Once Daily in the Evening on Nocturnal Lung Function and Sleep Parameters in Patients with Moderate Persistent Asthma

Clinical Drug Investigation ◽

10.2165/0044011-200929010-00005 ◽

2009 ◽

Vol 29 (1) ◽

pp. 51-58

Author(s):

John H Krouse ◽

Helene J Krouse ◽

James J Janisse

Keyword(s):

Lung Function ◽

Dry Powder Inhaler ◽

Persistent Asthma ◽

Mometasone Furoate ◽

Dry Powder ◽

Once Daily ◽

Sleep Parameters ◽

Moderate Persistent Asthma

Download Full-text

Impulse oscillometry in evaluation bronchial hyperresponsivness in patients with persistent allergic rhinitis

Vojnosanitetski pregled ◽

10.2298/vsp160407236k ◽

2018 ◽

Vol 75 (1) ◽

pp. 39-45

Author(s):

Dragan Koruga ◽

Nenad Baletic ◽

Kristina Tot-Veres ◽

Aleksandar Peric

Keyword(s):

Allergic Rhinitis ◽

Lung Function ◽

Challenge Test ◽

Provocation Test ◽

High Sensitivity ◽

Poor Correlation ◽

Impulse Oscillometry ◽

Persistent Allergic Rhinitis ◽

Group 2 ◽

Group 1

Background/Aim. Impulse oscillometry (IOS) is a method for estimating lung function which is used for early detection of bronchial hyperresponsiveness (BHR) and asthma. The aim of the study was to determine the prevalence of BHR, the correlation between spirometry and IOS and sensitivity and specificity of IOS in proving BHR in patients with persistent allergic rhinitis. Methods. The study included 81 patients with allergic rhinitis. From all of them, medical history was taken, allergy testing was done, as well as measurements of parameters of lung function by the IOS and spirometry before and after nonspecific bronchial provocation test with histamin via Aerosol provocative system. Changes of the IOS parameters to fall in FEV1 of 20% were measured and compared with changes in the spirometry parameters. After bronchial challenge test subjects were divided into two groups: the group with BHR (group 1) and that without BHR (group 2). Results. The mean age of participants was 25.7 ? 5.7 years, and 50.5% were men. Out of the total number of subjects with allergy rhinitis, 56 (58.9%) had a positive BPT. After bronchoprovocation an average increase in the group 1 was 88.15% for Rrs5, 111.98% for Fres, and for AX 819.69%. The high degree of correlation between the IOS and spirometry was proven in the group 2, while the whole group 1 had a weak correlation between parameters of these two methods. High sensitivity and low specificity for Rrs5 and Fres compared to FEV1 in diagnosing BHR was proven. Conclusion. The study demonstrated a high prevalence of BHR in the study group of patients with persistent allergic rhinitis, poor correlation in relation to the spirometric measurements in the group with BHR and a high sensitivity and low specificity of IOS for the detection of early changes in the airways.

Download Full-text

Dupilumab improves lung function and reduces severe exacerbations in uncontrolled persistent asthma patients with ongoing allergic rhinitis

10.1183/1393003.congress-2017.pa3550 ◽

2017 ◽

Author(s):

Steven Weinstein ◽

Heribert Staudinger ◽

Sophie Guillonneau ◽

Christine Taniou ◽

Laurent Eckert ◽

...

Keyword(s):

Allergic Rhinitis ◽

Lung Function ◽

Persistent Asthma ◽

Asthma Patients

Download Full-text

How Could We Influence Systemic Inflammation in Allergic Rhinitis? The Role of H1 Antihistamines

Oxidative Medicine and Cellular Longevity ◽

10.1155/2018/3718437 ◽

2018 ◽

Vol 2018 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Ioana Adriana Muntean ◽

Ioana Corina Bocsan ◽

Nicolae Miron ◽

Anca Dana Buzoianu ◽

Diana Deleanu

Keyword(s):

Allergic Rhinitis ◽

Healthy Volunteers ◽

Systemic Inflammation ◽

Biological Evaluation ◽

Total Ige ◽

Persistent Allergic Rhinitis ◽

Exhaled Air ◽

Before And After ◽

H1 Antihistamines

The aim of the study was the analysis of adhesion molecules’ profile (ICAM-1, VCAM-1, and E-selectin) in patients with allergic rhinitis and the influence of H1 antihistamines on those markers. Seventy-nine patients with persistent allergic rhinitis (PAR) and 30 healthy volunteers were included in the study. The patients with PAR were treated with desloratadine 5 mg/day or levocetirizine 5 mg/day for 4 weeks. The clinical (rhinitis symptoms and total symptoms score (TSS), type of sensitization) and biological evaluation (total IgE, eosinophils, ICAM-1, VCAM-1, and E-selectin) as well as fractionate nitric oxide in exhaled air (FeNO) measurement was performed before and after treatment. The plasmatic levels of ICAM-1, VCAM-1, total IgE, and eosinophils and FeNO were significantly increased in patients with PAR compared to healthy volunteers. H1 antihistamines significantly improved TSS, with no differences between the investigated drugs. There was a significant decrease of eosinophils, total IgE, and FeNO after treatment. H1 antihistamines significantly decreased the plasmatic levels of ICAM-1 and E-selectin but not VCAM-1 compared to basal values. There is no difference between levocetirizine and desloratadine in the reduction of CAMs. A systemic inflammation characterized by increased levels of CAMs is present in patients with PAR. H1 antihistamines improve symptoms and reduce CAMs and FeNO levels after 1 month of treatment. H1 antihistamines might reduce the systemic inflammation which could be responsible to asthma occurrence in patients with PAR.

Download Full-text

Does unified allergic airway disease impact on lung function and type 2 biomarkers?

Allergy Asthma & Clinical Immunology ◽

10.1186/s13223-019-0388-4 ◽

2019 ◽

Vol 15 (1) ◽

Author(s):

Chris RuiWen Kuo ◽

Rory Chan ◽

Brian Lipworth

Keyword(s):

Allergic Rhinitis ◽

Lung Function ◽

Allergic Asthma ◽

Asthma Control ◽

Persistent Asthma ◽

Airway Disease ◽

Allergic Airway Disease ◽

Positive Skin Prick Test ◽

Positive Skin

AbstractThe concept of the unified allergic airway disease (UAD) recognises the association between allergic inflammation in the upper and lower airways. Patients with asthma and concomitant allergic rhinitis experience more asthma-related primary and secondary care visits. We therefore aimed to determine differences in asthma control (asthma control questionnaire ACQ-6), lung function (spirometry) and T2 biomarkers (FeNO and Eos) in relation to the presence of allergic rhinitis in patients with allergic asthma. Retrospectively, we evaluated a cohort of 60 consecutive patients with persistent asthma attending our research unit for screening into clinical trials. All included subjects were receiving inhaled corticosteroids (ICS) and had a positive skin prick test (SPT) to at least one common aeroallergen to fulfil the criterion of allergic asthma. Patients with UAD had a diagnosis of allergic asthma in addition to established concomitant allergic rhinitis. T2 biomarkers were significantly higher in patients with allergic rhinitis in contrast to those without. FEV1 % predicted and FEF25-75 % predicted were also significantly lower in patients with concomitant allergic rhinitis. However, there was no difference in ACQ-6 observed between groups. In summary, patients with allergic asthma, the presence of concomitant allergic rhinitis is associated with worse lung function and higher type 2 biomarkers.

Download Full-text