scholarly journals Neutrophil Gelatinase Associated Lipocalin Urin sebagai Deteksi Dini Acute Kidney Injury

Sari Pediatri ◽  
2016 ◽  
Vol 16 (3) ◽  
pp. 195
Author(s):  
Siti Aizah Lawang ◽  
Antonius Pudjiadi ◽  
Abdul Latief
Keyword(s):  
Acute Kidney Injury ◽  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Predictive Value ◽  
Area Under Curve ◽  
Kidney Injury ◽  
Cross Sectional ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Consecutive Sampling ◽  
Neutrophil Gelatinase

Latar belakang. Penelitian terkini fokus pada identifikasi biomarker yang lebih dini untuk acute kidney injury (AKI). Salah satunya adalah neutrophil gelatinase associated lipocalin (NGAL), protein 25 kDa yang merupakan potensial biomarker dini untuk AKI.Tujuan. Melihat neutrophil gelatinase associated lipocalin (NGAL) sebagai biomarker dini untuk acute kidney injury (AKI).Metode. Penelitian kualitatif dengan desain uji diagnostik. Pengambilan sampel secara cross sectional dan consecutive sampling pada 50 orang anak, terdiri atas 28 sepsis dan 22 sepsis berat di ruang rawat intensif anak di RS. Cipto Mangunkusomo Jakarta dan RS. Wahidin Sudirohusodo Makassar.Hasil. Terdapat perbedaan sangat bermakna kadar NGAL urin dan kreatinin berdasarkan beratnya sepsis (p<0,001). Nilai rerata sepsis 132,93 ng/mL dan sepsis berat 2159,98 ng/mL. Terdapat perbedaan bermakna antara beratnya AKI menurut kriteria RIFFLE dengan beratnya sepsis (p=0,013). Tidak terdapat hubungan bermakna antara kadar NGAL urin dengan kriteria RIFFLE (p=0,173). Nilai sensitifitas NGAL urin 100% dan spesifisitas 63,63%, positive predictive value 27,27%, negative predictive value 100% dan area under curve (AuOC) 0,826.Kesimpulan. Neutrophil gelatinase associated lipocalin (NGAL) dapat dipakai sebagai skrining AKI.

scholarly journals Evaluation of Urinary Neutrophil Gelatinase Associated Lipocalin (NGAL), as an Early Biomarker and Prognostic Factor of Contrast Induced Acute Kidney Injury (CI-AKI) following Cardiac Catheterization

2016 ◽  
Vol 33 (3) ◽  
pp. 133-139
Author(s):  
Azizun Nessa ◽  
Masud Ahmed ◽  
Md Amzad H Fakir ◽  
Mamun Mostafi
Keyword(s):  
Acute Kidney Injury ◽  
Serum Creatinine ◽  
Kidney Injury ◽  
Military Hospital ◽  
Urine Ngal ◽  
Cross Sectional ◽  
Delay In Diagnosis ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Patient Demographics ◽  
Neutrophil Gelatinase

Acute kidney injury (AKI) usually detected by s. creatinine, which rises after 48 hrs of insult causes delay in diagnosis and to take preventive or therapeutic measures. Hence amongst many neutrophil gelatinase associated lipocalin (NGAL) is emerging as early, sensitive, and most promising biomarker of AKI both in urine and plasma. This prospective cross sectional observational study was carried out in Combined Military Hospital (CMH) Dhaka from October 2011 to March 2012. A total of willing 100 adult patients undergoing elective coronary angiogram (CAG) with normal kidney function were included in this study. Our study defined contrast induced AKI (CI-AKI) as rise of serum creatinine by >25% or e”0.5 mg/dl from baseline after exposure to contrast media and urine NGAL e”100 ng/ml was taken as cut off value to predict AKI as calculated by ROC curve. The main outcome measures were urine NGAL at 4 hrs and serum creatinine at 48 hrs after CAG. Significant elevation of urine NGAL was noted in 9 patients after 4 hrs of CAG, of them 8 (8%) patients developed raised s. creatinine (AKI) after 48 hrs. Patient demographics and procedural factors were although statistically significant in few instances but none was predictive of AKI.J Bangladesh Coll Phys Surg 2015; 33(3): 133-139

scholarly journals Serum NGAL in Critically Ill Children in ICU from a Single Center in Egypt

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Doaa Mohammed Youssef ◽  
Asmaa Mohammed Esh ◽  
Ebthag Helmy Hassan ◽  
Tahia Mohammed Ahmed
Keyword(s):  
Positive Predictive Value ◽  
Negative Predictive Value ◽  
Critically Ill ◽  
Predictive Value ◽  
Characteristic Curve ◽  
Kidney Injury ◽  
Critically Ill Children ◽  
Control Group ◽  
Mortality And Morbidity ◽  
Neutrophil Gelatinase Associated Lipocalin

Introduction. The mortality and morbidity associated with acute kidney injury (AKI), unfortunately, remain unacceptably high. We aimed to detect the extent of serum neutrophil gelatinase-associated lipocalin (NGAL) to early detect AKI in critically ill children. Subjects and Methods. This is a case control study. It included 75 subjects that include 15 as controls and 60 critically ill children. Patients were further subdivided according to RIFLE criteria into two other categories: patients who developed AKI and patients who did not develop AKI. Serum NGAL assayed on admission and after 3 days. Results. There was significant increase in the level of NGAL among patients group when compared with control group. Also, 21.7% of children admitted to PICU developed AKI from which 8.3% needed dialysis. The receiver operating characteristic curve of NGAL at day 0 revealed AUC of 0.63 with 95% CI of 0.50–0.77. At a cutoff value of 89.5 ng/mL, the sensitivity of NGAL was 84.6%, while specifcity was 59.6%, positive predictive value was 36.7%, negative predictive value was 68.4%, and accuracy was 93.3% in diagnosis of AKI. Conclusion. We found that NGAL acts as a sensitive marker rather than a specific one for AKI. At the same time, it presents as a negative predictive value more valuable than being a positive predictive value in detecting AKI.

scholarly journals Biomarkers of acute kidney injury in patients with nephrotic syndrome

2020 ◽  
Author(s):  
Maria Brandão Tavares ◽  
Caroline Vilas Boas de Melo ◽  
Paula Neves Fernandes ◽  
Maria da Conceição Chagas de Almeida ◽  
Marcia Fernanda dos Santos Melo Carneiro ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Nephrotic Syndrome ◽  
Acute Tubular Necrosis ◽  
Kidney Injury ◽  
Proliferative Glomerulonephritis ◽  
Cross Sectional ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Tubular Necrosis ◽  
Kidney Injury Molecule 1 ◽  
Neutrophil Gelatinase

ABSTRACT Introduction: Emergence of acute kidney injury (AKI) in patients with nephrotic syndrome (NS) requires prompt diagnosis and differentiation between acute tubular necrosis (ATN) and proliferative glomerulonephritis. We studied the potential use of commercial urinary biomarkers' tests in the diagnosis of AKI in patients with NS. Methods: A cross sectional estimate of urinary concentrations of KIM-1 and NGAL was performed in 40 patients with NS: 9 with proliferative glomerulopathy, being 4 with AKI and 31 without proliferative glomerulopathy, being 15 with AKI. AKI was defined using the KDIGO criteria. Results: The mean age was 35 ± 16 years. The main diagnoses were focal and segmental glomerulosclerosis (10, 25%), membranous glomerulopathy (10, 25%), minimal change disease (7, 18%), lupus nephritis (6, 15%), and proliferative glomerulonephritis (3, 8%). Patients with ATN had higher levels of urinary KIM-1 (P = 0.0157) and NGAL (P = 0.023) than patients without ATN. The urinary concentrations of KIM-1 (P= 0.009) and NGAL (P= 0.002) were higher in patients with AKI than in patients without AKI. Urinary NGAL and KIM-1 levels were significantly higher in patients with ATN without proliferative glomerulonephritis than in patients with proliferative glomerulonephritis (P = 0.003 and P=0.024, respectively). Conclusions: Neutrophil gelatinase associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) estimates correlated with histological signs of ATN and were able to discriminate patients with AKI even in conditions of NS. Furthermore, urinary levels of NGAL and KIM-1 may be useful in the differential diagnosis of acute tubular necrosis and exudative glomerulonephritis in patients with nephrotic syndrome.

scholarly journals Comparison of urine neutrophil gelatinase-associated lipocalin to serum creatinine to assess kidney function in neonatal asphyxia

2017 ◽  
Vol 56 (6) ◽  
pp. 356 ◽  
Author(s):  
Winston Leonardo Tanzil ◽  
Rocky Wilar ◽  
Max Frans Josef Mantik ◽  
Adrian Umboh ◽  
Suryadi Nicolaas Napoleon Tatura
Keyword(s):  
Serum Creatinine ◽  
Kidney Function ◽  
Predictive Value ◽  
Kidney Tissue ◽  
Kidney Injury ◽  
Urinary Ngal ◽  
Cross Sectional ◽  
Neonatal Asphyxia ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Neutrophil Gelatinase

Background Infants with neonatal asphyxia have multiorgan damage, such as to the kidneys (50%), central nervous system (28%), cardiovascular system (25%), and lungs (23%). Neonatal asphyxia reduces kidney perfusion, often leading to acute kidney injury (AKI) after asphyxia. Neutrophil gelatinase-associated lipocalin (NGAL) levels in the blood, urine and kidney tissue increased rapidly in AKI. Urinary NGAL is proposed to have better performance in diagnosing AKI than creatinine due to its earlier, rapid level increase and it is less invasive.Objective To compare urinary NGAL to serum creatinine as a marker to assess kidney function in neonatal asphyxia.Methods Diagnostic comparison study with cross-sectional design was performed at neonatal intensive care unit (NICU) of Prof. Dr. R. D. Kandou Hospital, Manado from November 2015 to February 2016. All subjects had neonatal asphyxia. Data were analyzed using descriptive analysis, receiver-operator characteristic (ROC) curve, and Z-test.Results Urinary NGAL with cut-off point of 652.24 ng/mL can predict AKI in neonates with asphyxia with 100% sensitivity, 75% specificity, 52.3% positive predictive value, and 100% negative predictive value. Chi-square test resulted in a value of x2 = 20.036, P=0.0001).This shows that urinary NGAL levels >652,24 ng/mL can predicts AKI by 20 times in infants with neonatal asphyxia. So, urinary NGAL performs better than serum creatinine, therefore it can replace serum creatinine as an alternative non-invasive diagnostic test for diagnosing AKI in infants with neonatal asphyxia.Conclusion The diagnostic value of urinary NGAL is higher than that of serum creatinine in assessing kidney function in neonatal asphyxia. 

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