A COMPARATIVE STUDY OF ISOBARIC 0.5% LEVOBUPIVACAINE COMBINED WITH 50 MCG FENTANYL VERSUS ISOBARIC 0.5% ROPIVACAINE COMBINED WITH 50 MCG FENTANYL IN LUMBAR EPIDURAL ANAESTHESIA FOR ELECTIVE INFRAUMBILICAL SURGERY

In humans the combined administration of epidural anaesthesia and inhalation anaesthesia may result in cardiovascular instability associated with decreases in heart rate and blood pressure. Anaesthesia was induced with a combination of midazolam / ketamine in 18 female pigs with a mean body weight of 24.9±5.9 kg scheduled for surgical removal of the liver. After tracheal intubation, anaesthesia was maintained on a circle rebreathing circuit with isoflurane. Epidural anaesthesia was administered with ropivacaine (AL-group, n=8) at 0.2 mℓ / kg of a 7.5 mg / mℓ solution to the anaesthetised animals. The A-group (n = 10) received isoflurane anaesthesia only. The vaporiser was set at 2.5 % for the A-group and 1.5 % for the AL-group. Heart rate, invasive systolic, diastolic, and mean arterial blood pressure were monitored. Comparisons were made between treatments and within treatments comparing variables during surgical preparation and abdominal surgery. Differences between treatments were not statistically significant (P > 0.05) during surgical preparation or during abdominal surgery. For within treatment groups, the differences between surgical preparation and abdominal surgery were statistically significant (P < 0.05) for heart rate in the A-group, but not statistically significant (P > 0.05) for the other variables. It is concluded that abdominal surgery may be associated with statistically significant changes in heart rate in isoflurane-anaesthetised pigs and that the combined administration of epidural ropivacaine may prevent statistically significant changes in HR during abdominal surgery.

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A COMPARATIVE STUDY OF LEVOBUPIVACAINE 0.5% AND BUPIVACAINE 0.5% IN EPIDURAL ANAESTHESIA IN ELECTIVE LOWER LIMB SURGERIES IN ADULTS

Journal of Evolution of Medical and Dental Sciences ◽

10.14260/jemds/2017/826 ◽

2017 ◽

Vol 6 (50) ◽

pp. 3822-3827

Author(s):

Vijayanand Siddalingappa ◽

Manisha Mohan Shivamoggi

Keyword(s):

Comparative Study ◽

Epidural Anaesthesia ◽

Lower Limb

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Combined spinal epidural anaesthesia versus epidural anaesthesia: a comparative study

Journal of Chitwan Medical College ◽

10.3126/jcmc.v10i2.29669 ◽

2020 ◽

Vol 10 (2) ◽

pp. 36-39

Author(s):

Pramesh Sunder Shrestha ◽

Ninadini Shrestha ◽

Anil Shrestha ◽

Roshana Amatya ◽

Bigen Man Shakya ◽

...

Keyword(s):

Comparative Study ◽

Epidural Anaesthesia ◽

Epidural Block ◽

Spinal Block ◽

Epidural Group ◽

Hyperbaric Bupivacaine ◽

Chi Square ◽

Cross Sectional ◽

Group B ◽

Spinal Epidural

Background: Regional anaesthesia are widely utilized in surgical gynaecology practice. The Combined Spinal Epidural Anaesthesia (CSEA) technique and Continuous epidural anaesthesia both have been extensively used in elective gynaecological surgeries. This prospective cross-sectional comparative study was designed to compare the quality of anaesthesia between CSEA and Epidural anaesthesia. Methods: Sixty-four patients between age group 15- 65 years of ASA grade I, II were randomly divided into 2 groups. Group A patients received CSEA using “double needle double interspace technique” and were given 2.5 ml of 0.5% hyperbaric bupivacaine for spinal block. Group B patients received epidural block with catheter using 10 ml of 0.5% plain bupivacaine. In all patients, subsequent dosage of 2 ml per unblocked segment 0.5% plain bupivacaine was administered through the epidural catheter to achieve a block up to T4-5. Mean was calculated using t-test, median with Mann Whitney U test and Chi-square test where appropriate and the Statistical Analysis was done using SPSS program, version 11.0. Results: The surgical anaesthesia and motor blockade occurred significantly early in CSEA group. Duration of analgesia was significantly shorter in CSEA (84.1±40.6 min) as compared to epidural group (138.6±32.9 min). The total amount of bupivacaine required to attain the same target level was two times in epidural group (p<0.05). Haemodynamic changes were comparable in both the groups. No neurological side effects were observed. Conclusions: Sequential CSEA is superior alternative to epidural block, which combines the advantages of spinal and epidural while minimizing their drawbacks in elective gynaecological surgeries.

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