Rational computational design of protein binders for biosensor and therapeutic applications

2021 ◽  
Author(s):  
◽  
Jake Parker
Keyword(s):  
Computational Design ◽  
Therapeutic Applications ◽  
Protein Binders

scholarly journals Computational design and experimental optimization of protein binders with prospects for biomedical applications

2021 ◽  
Vol 34 ◽  
Author(s):  
Alessandro Bonadio ◽  
Julia M Shifman
Keyword(s):  
Biomedical Applications ◽  
Production Cost ◽  
High Stability ◽  
Computational Design ◽  
Computational Approaches ◽  
Natural Protein ◽  
Protein Binders ◽  
Experimental Approaches ◽  
Near Future ◽  
Agent Development

Abstract Protein-based binders have become increasingly more attractive candidates for drug and imaging agent development. Such binders could be evolved from a number of different scaffolds, including antibodies, natural protein effectors and unrelated small protein domains of different geometries. While both computational and experimental approaches could be utilized for protein binder engineering, in this review we focus on various computational approaches for protein binder design and demonstrate how experimental selection could be applied to subsequently optimize computationally-designed molecules. Recent studies report a number of designed protein binders with pM affinities and high specificities for their targets. These binders usually characterized with high stability, solubility, and low production cost. Such attractive molecules are bound to become more common in various biotechnological and biomedical applications in the near future.

Computational Design of Novel Protein Binders and Experimental Affinity Maturation

2013 ◽  
pp. 1-19 ◽  
Author(s):  
Timothy A. Whitehead ◽  
David Baker ◽  
Sarel J. Fleishman
Keyword(s):  
Computational Design ◽  
Affinity Maturation ◽  
Protein Binders ◽  
Novel Protein

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

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