2492 Everolimus-Induced Transaminitis in the Setting of Stage IV Carcinoid Tumor With Liver Metastasis

2019 ◽  
Vol 114 (1) ◽  
pp. S1371-S1371 ◽  
Author(s):  
Christian Nehme ◽  
Sami Ghazaleh ◽  
Marcel Ghanim ◽  
Zeid Nesheiwat ◽  
Mohammed Awad ◽  
...  
Author(s):  
Masakazu Ikenaga ◽  
Ho Min Kim ◽  
Yusuke Matsuura ◽  
Toshiki Hitora ◽  
Masaki Hirota ◽  
...  

2020 ◽  
Author(s):  
Zhilong Wang ◽  
Xin Sun ◽  
Fengli Zhang ◽  
Ting Wang ◽  
Ping Li

Abstract Background: Adrenocortical carcinoma(ACC) is a rare and highly invasive endocrine malignant tumor with poor prognosis and insensitivity tochemotherapy, which don't have effective treatment. Although Surgical resection is considered to be the main treatment for ACC, postoperative recurrence and metastasis have become the most important factors of death. Therefore, local treatments such as trans-catheter arterial chemo-embolization, radiofrequency ablation become be new treatment for ACC. Trans-catheter arterial chemo-embolization therapy for ACC patients with liver metastasis has good efficacy and can effectively reduce the tumor burden of patients, which is considered to be safe and easy for patients. Case presentation: We report a 47-year-old female patient diagnosed with stage Ⅳ ACC with liver metastases, who developed symptoms of acute adrenocortical dysfunctions after hepatic arterial catheter chemo-embolization.Conclusion: Trans-catheter arterial chemo-embolization therapy for ACC patients with liver metastasis is not completely safe, and there is a certain probability that it will lead to secondary adrenal dysfunction. Hydrocortisone supplementation can effectively alleviate the symptoms.


1996 ◽  
Vol 43 (4) ◽  
pp. 623 ◽  
Author(s):  
Dong Soo Lee ◽  
Tae Won Lee ◽  
Gye Yeon Kim ◽  
Hwi Jung Kim ◽  
So Hyang Song ◽  
...  

Haigan ◽  
2012 ◽  
Vol 52 (2) ◽  
pp. 232-237
Author(s):  
Yutaka Takeuchi ◽  
Eiki Kikuchi ◽  
Iki Ogura ◽  
Satoshi Oizumi ◽  
Masaharu Nishimura

1994 ◽  
Vol 44 (0) ◽  
pp. 186-187 ◽  
Author(s):  
Shigeru Sorimachi ◽  
Jun Sasaki ◽  
Tsugio Yoshimine ◽  
Toushoku Minoo ◽  
Hirofumi Ohtagaki ◽  
...  

1999 ◽  
Vol 32 (9) ◽  
pp. 2283-2286 ◽  
Author(s):  
Tsuyoshi Igami ◽  
Hiroshi Hasegawa ◽  
Seiji Ogiso ◽  
Masaya Shiomi ◽  
Masato Momiyama ◽  
...  

2020 ◽  
Vol 115 (1) ◽  
pp. S1466-S1467
Author(s):  
Sandra Gomez Paz ◽  
Pranay Srivastava ◽  
Kaleem Rizvon

Author(s):  
Daniel Anaya ◽  
Bela Kis ◽  
Daniel Anaya ◽  
Jasmina Ehab ◽  
Julie E. Hallanger Johnson ◽  
...  

Introduction: Adrenocortical carcinoma (ACC) is an aggressive tumor with high proportion of patients presenting with metastatic disease, most commonly in the liver. Prognosis in this population is extremely poor. Resection of the primary tumor and liver metastasis offers a survival benefit in well-selected patients. However, the extent of surgery is often significant and can limit the ability to accomplish a safe marginnegative resection. Presentation of case: A 35-year-old male presented with a large left ACC (15.2cm) and multiple bilobar liver metastases (1.5-12.5cm). He was treated with mitotane and chemotherapy / immunotherapy, with excellent response. Multidisciplinary discussion led to recommendations for a curative-intent approach with surgery. A staged approach was performed for the resection, using a modified Mini-ALPPS technique. A complete margin-negative resection of all disease was accomplished. The patient recovered well and remains free of disease 24-months following diagnosis. Discussion: This case highlights novel components of treatment for metastatic ACC and for hepatectomy for bilobar liver metastasis. The decisions to proceed to surgery for complete resection and to use a staged approach with a modified Mini-ALPPS technique were both critical components to render the patient disease-free. Appropriate expertise and multidisciplinary teamwork are essential for implementation of these approaches. Conclusion: Neoadjuvant chemotherapy for stage IV ACC can result in disease control and improved selection of candidates for curative-intent surgery. In the setting of bilobar liver disease and a large primary in place, a modified Mini-ALPPS approach provides a safe and feasible way to accomplish complete resection and improved survival.


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