Cerebral ischemia as a marker of depression and cognitive disorders in patients with type 2 diabetes mellitus

AbstractBackground and aims: Depression and cognitive disorders were reported more frequently in patients with diabetes mellitus (DM). Our aim was to analyze the association of cognitive disorders and depression association with chronic complications of DM in a group of Romanian patients. Materials and methods: The data was analyzed from 181 patients, with a mean age of 58,3 years to whom we applied the MMSE (Mini- Mental State Examination) and MADRS (Montgomery-Asberg Depression Rating Scale) questionnaires. We also analyzed the presence of chronic DM complications, HbA1c and lipid profile. Results: Most patients with type 2 diabetes mellitus (T2DM) had mild cognitive impairment (92%), more common in the age group 50-59 years. Chronic macrovascular complications were present in 74.58%, while chronic microvascular complications were present in 61.87% of patients with T2DM who associated mild and moderate cognitive impairment (p = 0.013). The most common form of depression was mild depression (90.2%), present in most patients with DM, regardless of progression and type of treatment. MADRS depression test scores were statistically significant correlated with the presence of peripheral artery disease - PAD (p <0.001), ischemic heart disease - IHD (p <0.001) and chronic kidney disease - CKD (p =0.05). We did not find a statistically significant correlation with HbA1c and serum lipid values (p˃0,05). Conclusion: Chronic diabetes macrovascular complications (PAD, IHD) and CKD were more frequently associated with cognitive disorders and depression in patients with T2DM independent of the degree of metabolic control.

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Predictors of moderate cognitive disorders in patients with coronary heart disease and type 2 diabetes mellitus

Clinical Medicine (Russian Journal) ◽

10.18821/0023-2149-2016-94-1-31-35 ◽

2016 ◽

Vol 94 (1) ◽

pp. 31-35 ◽

Cited By ~ 1

Author(s):

Olga A. Trubnikova ◽

I. V. Tarasova ◽

A. S. Mamontova ◽

E. S. Kagan ◽

O. V. Maleva ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Type 2 Diabetes Mellitus ◽

Heart Disease ◽

Cognitive Disorders ◽

Cognitive Status ◽

Homa Index ◽

Trait And State Anxiety

Aim. To study predictors of moderate cognitive disorders (MCD) in patients with coronary heart disease (CHD) and type 2 diabetes mellitus (DM2). Materials and methods. The study included 54 men with CPD and DM2 (mean age 56.8±4.5 years). Standard medical examination was supplemented by the assessment of cognitive status, characteristics of lipid and carbohydrate metabolism. Factors allegedly influencing MCD development included the patients’ age, education level, stenosis of carotid arteries, LV ejection fraction, arterial hypertension, insulin and HbAlc levels, HOMA and QUICKI indices, lipid metabolism, concentrations of total, HDL and LDL cholesterol, fructosamine, triglycerides, severity of coronary lesions (Syntax scale), trait and state anxiety. Results. Fructosamine level and HOMA index were the most important characteristics responsible for MCD in patients with CPD and DM2. Conclusion. The data obtained demonstrate the significance of fructosamine level and HOMA index in the development of MCD in patients with CPD and DM2.

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Potential Risk Factors of the Cognitive Dysfunction in Patients with Type 2 Diabetes Mellitus

Romanian Journal of Diabetes Nutrition and Metabolic Diseases ◽

10.2478/rjdnmd-2018-0038 ◽

2018 ◽

Vol 25 (3) ◽

pp. 321-328

Author(s):

Bondar Andrei-Cristian ◽

Popa Amorin-Remus

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Potential Risk ◽

Vascular System ◽

Cognitive Disorders ◽

Cerebrovascular Lesions ◽

Potential Risk Factors

Abstract It is known that the aged persons with type 2 diabetes mellitus present a high risk for developing neurocognitive disorders and in order to explain this phenomenon we have proposed some potential risk factors. They can be involved in the causality patterns or can act as useful markers of the cerebrovascular lesions (or both) and for which there are strong proofs, including the poor glycemic control, hypoglycemia, microvascular diseases, inflammation or depression. For the macrovascular affections, the association with the cognitive disorders seems to devolve on the examined vascular system. It is put into discussion that for the next researches it is important to analyze how exactly the interrelations between the risk factors can contribute to cognitive disorders.

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Cerebral hemodynamics in patients with type 2 diabetes mellitus and chronic kidney disease

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY ◽

10.22141/2224-0721.17.6.2021.243213 ◽

2021 ◽

Vol 17 (6) ◽

pp. 486-490

Author(s):

A.Yu. Kholikov ◽

Yu.M. Urmanova

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Chronic Kidney Disease ◽

Blood Flow ◽

Type 2 Diabetes Mellitus ◽

Cerebral Ischemia ◽

Kidney Disease ◽

Cerebral Hemodynamics ◽

Control Group

Background. The main risk factors for cardiovascular diseases (CVD) are diabetes mellitus, anemia, microalbuminuria, proteinuria, azotemia, hyperlipidemia, obesity, smoking, lack of physical activity, and non-traditional factors are metabolic and hemodynamic disorders. The combined effect of diabetes mellitus and renal insufficiency increases the risk of CVD and confirms the worse survival prognosis of these patients compared to the general population. The study was aimed to study changes in the parameters of cerebral hemodynamics in patients with type 2 diabetes mellitus receiving programmed hemodialysis. Materials and methods. During the period from January 1, 2019 to June 1, 2021, 117 patients suffering from type 2 diabetes mellitus with chronic renal failure stage V on programmed hemodialysis were examined and observed. Of these, there were 58 women and 59 men. The average age of men was 67.0 ± 4.2 years, women — 64.0 ± 5.6 years. Twenty patients of the matched age formed the control group. The number of hemodialysis sessions in patients ranged from 2 to 162. All patients underwent examinations that included general clinical, biochemical, hormonal blood tests, Dopplerography of the main arteries of the head. Results. With the increasing degree of cerebral ischemia, the linear velocity of blood flow (LBFV) decreased in all the main arteries of the head: the common carotid artery, the internal carotid artery, the vertebral artery on both sides (p < 0.05). At the same time, the differences in the LBFV from healthy individuals were significant. The stenosis of the lumen of the main vessels of the head occurred mostly in patients of the third group with stage V diabetic nephropathy and grade III chronic cerebral ischemia, while they most often had multiple vascular stenosis. Conclusions. Dopplerography of the main arteries of the head is an informative method for determining the prognosis of cerebral ischemia in patients with type 2 diabetes mellitus and chronic kidney disease. Linear blood flow velocity was reduced in all groups of patients with type 2 diabetes mellitus and chronic kidney disease.

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