scholarly journals Complete form of the testicular feminization syndrome with dysherminoma in one testicle combiner with prolactinoma

2001 ◽  
Vol 47 (1) ◽  
pp. 30-34
Author(s):  
L. K. Dzeranova ◽  
M. E. Bronstein ◽  
E. I. Marova ◽  
A. V. Vorontsov ◽  
A. A. Pishchulin ◽  
...  
Keyword(s):  
Testicular Feminization ◽  
Complete Form

The article is devoted to the study of the complete form of the testicular feminization syndrome with dysherminoma in one testicle combiner with prolactinoma.

THE METABOLISM OF TESTOSTERONE, ANDROSTENEDIONE AND OESTRONE BY TESTES FROM A CASE OF TESTICULAR FEMINIZATION

1968 ◽  
Vol 42 (3) ◽  
pp. 391-403 ◽  
Author(s):  
A. P. WADE ◽  
G. S. WILKINSON ◽  
J. C. DAVIS ◽  
T. N. A. JEFFCOATE
Keyword(s):  
Testicular Tissue ◽  
Major Metabolite ◽  
Testicular Feminization ◽  
Phenolic Fraction ◽  
Enzyme Systems ◽  
Before And After ◽  
Complete Form ◽  
Urinary Steroid ◽  
Chromatographic Evidence

SUMMARY [4-14C]Testosterone, [4-14C]androstenedione and [4-14C]oestrone were incubated with testicular tissue obtained from an 18-yr.-old patient with the complete form of the testicular feminization syndrome. Considerable biosynthesis of testosterone from androstenedione occurred, but metabolism of testosterone by the tissue was minimal. The small phenolic fraction from these incubations did not contain any recognizable oestrogens. Metabolism of oestrone was almost complete, less than 4% being recovered as unchanged oestrone. Of eight areas of radioactivity found during chromatography, five were shown to be associated with oestrone, 2-methoxyoestrone, oestradiol-17β, 2-hydroxyoestradiol-17β, and 2-methoxy-oestradiol-17β. Chromatographic evidence suggested that an oxo-oestrone and a compound more polar than oestriol were present. No oestriol was found. The results confirm those of other workers to the effect that testosterone is the major metabolite of androstenedione in feminizing testes. Incubation of the testes with oestrone showed them also to possess the enzyme systems necessary for hydroxylation at position 2 and the subsequent methylation of this group. Urinary steroid measurements before and after removal of the testes showed these organs to be actively secreting. Attempts to demonstrate oestrogenic activity in the urine additional to that accounted for by chemical estimation were unsuccessful.

The role of oestrogens on gonadotrophin secretion in the testicular feminization syndrome1

1980 ◽  
Vol 95 (3) ◽  
pp. 314-318 ◽  
Author(s):  
Martha Medina ◽  
Alfredo Ulloa-Aguirre ◽  
Maria A. Fernández ◽  
Gregorio Pérez-palacios
Keyword(s):  
Clomiphene Citrate ◽  
Poor Response ◽  
Testicular Feminization ◽  
Normal Response ◽  
Serum Lh ◽  
Gonadotrophin Secretion ◽  
Before And After ◽  
Complete Form ◽  
Lh Secretion

Abstract. The role of oestrogens on gonadotrophin secretion was assessed in three related patients with the complete form of testicular feminization syndrome. Serum LH and FSH levels were measured before and after I.RH stimulation as well as before, during and after chronic clomiphene citrate administration. Moderately elevated LH basal levels with a significant LH rise following I.RH were observed. Normal or even low FSH level with poor response to LRH were found in all subjects. Administration of clomiphene citrate resulted in a significant serum LH increase without any change of FSH. Following castration both LH and FSH rose and a normal response to LRH was observed. These results were interpreted as demonstrating that, while endogenous oestrogens modulate LH secretion in patients with androgen unresponsiveness, it plays no role in regulating FSH secretion and suggested that a factor of testicular origin without androgenic or oestrogenic activity is responsible for FSH regulation.

Steroid Biosynthesis in Gonadal Tissue from Patients with Testicular Feminization

1972 ◽  
Vol 50 (8) ◽  
pp. 849-855 ◽  
Author(s):  
C. Cardiff ◽  
V. Uden ◽  
D. W. Killinger
Keyword(s):  
Dehydroepiandrosterone Sulfate ◽  
Testicular Tissue ◽  
Biologically Active ◽  
Testicular Feminization ◽  
Steroid Biosynthesis ◽  
Younger Patients ◽  
Gonadal Tissue ◽  
Complete Form ◽  
Testosterone Biosynthesis ◽  
Steroid Sulfate

The biosynthesis of sulfate conjugates and unconjugated steroids has been compared in two siblings aged 19 and 21, and a 52-year-old patient with the complete form of testicular feminization. Incubation of homogenates of gonadal tissue with 14C-pregnenolone (P) and 3H-pregnenolone-sulfate (PS) revealed that the conversion of P to PS was 6.8% in the older subject, and less than 1% in the two younger subjects; and the conversion to dehydroepiandrosterone sulfate (DHAS) was 24.2% in the older subject, and 2.1 and 0.2% in the two younger subjects. The recovery of unmetabolized PS was 41.9% in the older subject, and 5.0 and 13.7% in the two younger subjects. The formation of testosterone from P was 4.2 and 2.2% in the two younger subjects, and 0.5% in the older subject, and the 3H/14C ratio indicated that the utilization of PS in testosterone biosynthesis was greater in the younger patients than in the older subject. Incubation of 14C-dehydroepiandro-sterone (D) and 3H-DHAS with testicular tissue from the 21-year-old subject confirmed the high testosterone production and steroid sulfate utilization in the younger subject.These findings raise the possibility that with age there may be a shift from the biosynthesis of biologically active unconjugated products to less biologically active sulfate conjugates in testicular tissue.

ENDOCRINE STUDIES IN PATIENTS WITH TESTICULAR FEMINIZATION

1974 ◽  
Vol 77 (1_Suppl) ◽  
pp. S45
Author(s):  
A.E. Schindler ◽  
E. Keller ◽  
E. Friedrich ◽  
E.R. Jaeger-Whitegiver ◽  
E.W. Joel ◽  
...  
Keyword(s):  
Testicular Feminization

Mesyatseslovs memory of the Russian Orthodox Church

2020 ◽  
pp. 160-198
Author(s):  
Макарий Веретенников
Keyword(s):  
Russian Orthodox ◽  
Orthodox Church ◽  
Russian Orthodox Church ◽  
Analysis And Synthesis ◽  
Liturgical Texts ◽  
History Of ◽  
Complete Form ◽  
Characteristic Features ◽  
Heaven And Earth ◽  
The Church

Статья посвящена содержанию, общим принципам построения и характерным особенностям календаря, или месяцеслова, Русской Православной Церкви. Автор использует методы анализа и синтеза. В итоге делаются нижеследующие обобщения. Месяцеслов был принесён на Русь из Византии в достаточно завершённом виде, однако в процессе исторического развития он дополнился особенными русскими праздниками. Календарь-месяцеслов - это грандиозный собор святых, подвизавшихся в разных местах на протяжении веков, единение Церкви Небесной и земной, история святости и история нашей Церкви. Месяцесловным памятям посвящены составленные гимнографами богослужебные тексты, которые поются и читаются в храмах. Традиционно почитается день кончины угодников Божиих, память открытия мощей святых, перенесения их святых мощей или же день канонизации угодников Божиих, реже - день их рождения. Фенологические наблюдения русского народа связаны с повседневной деятельностью и увязаны с месяцесловом, что свидетельствует о его проникновении в повседневную жизнь русского человека. The article is devoted to the content, General principles of construction and characteristic features of the calendar, or mesyatseslov, of the Russian Orthodox Church. The author uses methods of analysis and synthesis. As a result, the following generalizations are made. The mesyatseslov was brought to Russia from Byzantium in a fairly complete form, but in the course of historical development it was supplemented with special Russian holidays. The calendar-mesyatseslov is a grandiose council of saints who have labored in different places over the centuries, the unity of the Church of Heaven and earth, the history of holiness and the history of our Church. Liturgical texts composed by hymnographers, which are sung and read in churches, are dedicated to the mesyatseslovs memory. Traditionally, the day of the death of saints, the memory of the discovery of the relics of saints, the transfer of their Holy relics, or the day of the canonization of saints, less often - the day of their birth are honored. Russian people’s phenological observations are related to their daily activities and are linked to mesyatseslov, which indicates its penetration into the daily life of the Russian people.

Testicular Feminization Syndrome

1964 ◽  
Vol 24 (3) ◽  
pp. 425-427
Author(s):  
EUGENE H. RUFFOLO
Keyword(s):  
Testicular Feminization
Sign in / Sign up

Export Citation Format

Share Document