scholarly journals The case of histiocytosis X (Hand - Schüller – Christian disease) with thyroid gland lesion

1996 ◽  
Vol 42 (3) ◽  
pp. 26-29
Author(s):  
M. E. Bronstein ◽  
G. A. Melnichenko ◽  
A. I. Bukhman ◽  
T. A. Starostina ◽  
O. L. Ivanov ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Rare Disease ◽  
Clinical Manifestation ◽  
Clinical Picture ◽  
Langerhans Cells ◽  
Morphological Changes ◽  
Eosinophilic Granuloma ◽  
Biological Significance ◽  
Histiocytosis X ◽  
Mutual Transition

Histiocytosis X, which is a rare disease, combines 3 related but different in clinical manifestation, course and prognosis of the syndrome: eosinophilic granuloma (Taratynovs disease), Hand Schller Christian disease (syndrome) and Letterer Siw disease (syndrome). The clinical picture of Hend Schller Christian disease was first described by Hand in 1893, then by Schller in 1915 and Christian in 1920. The term histiocytosis X was first proposed in 1953 by Liechtenstein, who combined all 3 of the aforementioned diseases under this name. on the basis of the similarity of the clinical picture, the possibility of a mutual transition from one state to another and typical morphological manifestations consisting in the proliferation of histiocytes and the accumulation of various lipids in their cytoplasm. In 1965, this concept was confirmed in all three diseases, there are no special pentalaminar markers in the cytoplasm of histiocytes that are detected in Langerhans cells (hence the name of these inclusions - "Langerhans cell granules"), the origin and biological significance of which remains unclear. Histiocytes have no signs of atypia, although they infiltrate many organs and tissues retain their normal properties. Histiocytic proliferation can develop in various organs and tissues, causing them to corresponding functional and morphological changes.

scholarly journals Cervical thymoma

1999 ◽  
Vol 117 (3) ◽  
pp. 132-135 ◽  
Author(s):  
Abrão Rapoport ◽  
Claudiane Ferreira Dias ◽  
João Paulo Aché de Freitas ◽  
Ricardo Pires de Souza
Keyword(s):  
Case Report ◽  
Thyroid Gland ◽  
Rare Disease ◽  
Female Patient ◽  
Thallium 201 ◽  
Accurate Diagnosis ◽  
Nuclear Resonance ◽  
Histological Findings ◽  
History Of ◽  
Iodine 131

CONTEXT: Cervical thymoma is a primitive thymic neoplasia. It is very rare. This disease presents higher incidence in female patients in their 4th to 6th decade of life. We present a case report of a cervical thymoma CASE REPORT: 54-year-old female patient, caucasian, with no history of morbidity, presenting a left cervical nodule close to the thyroid gland. During the 30 months of investigation a left cervical nodule grew progressively next to the thyroid while the patient showed no symptoms, making accurate diagnosis difficult. Tests on her thyroid function did not show changes, nor were there changes in any subsidiary tests. The diagnosis of the disease was made intra-operatively through total thyroid individualization. The results were confirmed by the histological findings from the ressected material. Cervical thymoma is a very rare disease, with difficult preoperatory diagnosis. Some additional study methods which are employed today are thallium 201, technetium 99 and iodine 131 scintigraphy, magnetic nuclear resonance and especially histopathological findings and classification.

scholarly journals Hormones of thyroid gland in sera of rats treated with different dose of concentrated potassium iodine solutions

2010 ◽  
Vol 138 (5-6) ◽  
pp. 323-327 ◽  
Author(s):  
Ljiljana Markovic ◽  
Violeta Mihailovic-Vucinic ◽  
Jelena Aritonovic
Keyword(s):  
Thyroid Gland ◽  
Genetic Susceptibility ◽  
Experimental Model ◽  
Wistar Rats ◽  
Morphological Changes ◽  
Cell Necrosis ◽  
High Iodine ◽  
Hormone Status ◽  
Potassium Iodine ◽  
Iodine Dose

Introduction Potassium iodine (KI) is used as a drug therapy for treating numerous diseases such as small-vessel vasculitis, erythema nodosum, vasculitis nodularis, Sweet's syndrome, tuberculosis and granulomatosis, and for iodized salt. At the same time, KI can be harmful. Iodine intake may increase the frequency of thyroiditis in humans, and may induce the occurrence of experimental thyroiditis (ET) in animals. Investigations on an experimental model for the examination of thyroiditis in Wistar rats have clearly showed morphological changes in the rat thyroid evoked by KI administration. Objective The purpose of this study was to compare the effects of low and high doses of KI on the thyroid gland of Wistar rats and determine the effect on hormone status (T4, T3 and TSH) in this rat strain. Methods Two groups of rats from the Wistar strain were treated with a low iodine dose (225 ?g/g BW) and with a high iodine dose (675 ?g/g BW) of KI solutions. Untreated nonimmunized animals served as controls. The solution was administrated daily intraperitoneally during the period of 26 consecutive days. Results Monitoring hormone status (TSH, T3 and T4) and morphological changes it was found that therapeutic doses of KI applied in treatment induced the occurrence of experimental thyroiditis (chronic destructive Hashimoto's thyroiditis in humans) and cell necrosis in animals not carrying a genetic susceptibility. Significant inflammatory changes were observed in rats treated with a high iodine dose. Conclusion The early iodine induced cell necrosis and inflammation in the nonimmunized animals without genetic susceptibility is a new experimental model of thyroiditis. .

Pulmonary Histiocytosis X (Eosinophilic Granuloma)

1996 ◽  
Vol 3 (4) ◽  
pp. 191-198 ◽  
Author(s):  
Moisés Selman ◽  
Guillermo Carrillo ◽  
Miguel Gaxiola ◽  
C. Ramos
Keyword(s):  
Eosinophilic Granuloma ◽  
Histiocytosis X ◽  
Pulmonary Histiocytosis ◽  
Pulmonary Histiocytosis X

DYNAMIC MORPHOLOGICAL CHANGES IN THE THYROID GLAND ASSOCIATED WITH DEPLETION OF DEUTERIUM BODY CONTENT

2021 ◽  
Author(s):  
Ekaterina Timokhina ◽  
◽  
Nataliya Yaglova ◽  
Sergey Obernikhin ◽  
Valentin Yaglov ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Morphological Changes ◽  
Hormone Secretion ◽  
Deuterium Content ◽  
Thyroid Cells

Dynamics of morphological changes in the thyroid gland of mice, consuming water with lower deuterium content, was studied. Primary changes in structure were indicative of more active hormone secretion. Later morphological signs of inhibited hormone secretion were found. The findings demonstrate sensitivity of thyroid cells to shifts in deuterium body con-tent.

Eosinophilic granuloma of lymph nodes?a variant of histiocytosis X

1980 ◽  
Vol 4 (6) ◽  
pp. 585-606 ◽  
Author(s):  
M. MOTOI ◽  
DAGMAR HELBRON ◽  
E. KAISERLING ◽  
K. LENNERT
Keyword(s):  
Lymph Nodes ◽  
Eosinophilic Granuloma ◽  
Histiocytosis X

scholarly journals Inactivation of the Stress- and Starvation-Inducible gls24 Operon Has a Pleiotrophic Effect on Cell Morphology, Stress Sensitivity, and Gene Expression inEnterococcus faecalis

2000 ◽  
Vol 182 (16) ◽  
pp. 4512-4520 ◽  
Author(s):  
Jean-Christophe Giard ◽  
Alain Rince ◽  
Herve Capiaux ◽  
Yanick Auffray ◽  
Axel Hartke
Keyword(s):  
Gene Expression ◽  
Bile Salts ◽  
Morphological Changes ◽  
Tap Water ◽  
Stress Protein ◽  
Biological Significance ◽  
Stress Sensitivity ◽  
Northern Analysis ◽  
Alkaline Stress ◽  
Wild Type

ABSTRACT Enterococcus faecalis induces the synthesis of at least 42 proteins during 24 h of glucose starvation. Because of its induction during carbohydrate and complete starvation (incubation in tap water) and CdCl2 and bile salts stresses, one of these proteins (Gls24) was qualified as a “general stress protein” and was analyzed at the molecular level. Its corresponding gene,gls24, seems to be the penultimate gene of an operon composed, altogether, of six open reading frames (ORFs). The ORF preceding gls24 (orf4) showed very strong identity with gls24. The deduced polypeptides of these two genes showed similarity with a 20-kDa hypothetical protein fromLactococcus lactis and an alkaline stress protein fromStaphylococcus aureus with no previously known biological significance. Data from the operon sequence and Northern analysis led to the conclusions that (i) gls24 possesses its own promoter which is especially induced at the onset of starvation and (ii) the operon promoter is stress inducible in exponential-phase cells. A mutation in the gls24 gene led to a severe reduction of growth rate and reduction of survival against 0.3% bile salts in the 24-h-starved cells compared to the wild-type strain. Moreover, the chain length of the mutant is significantly reduced during growth. These results argue strongly for a role of the protein Gls24 and/or GlsB in morphological changes and in stress tolerance inE. faecalis. Comparison of two-dimensional protein gels from wild-type cells with those from gls24 mutant cells revealed a pleiotropic effect of the mutation on gene expression. At least nine proteins were present in larger amounts in the mutant. For six of them, the corresponding N-terminal microsequence has been obtained. Three of these sequences map in genes coding forl-lactate dehydrogenase, lipoamide dehydrogenase, and pyruvate decarboxylase, all involved in pyruvate metabolism.

Morphological characteristic and assessment of changesin the main structural components of the histohematological barrier of the thyroid tissue in cases of the sudden cardiac death from alcoholic cardiomyopathy

2017 ◽  
Vol 8 (5) ◽  
pp. 30-34
Author(s):  
Olga V. Sokolova ◽  
Orazmurad D. Yagmurov ◽  
Ruslan A. Nasyrov
Keyword(s):  
Sudden Cardiac Death ◽  
Thyroid Gland ◽  
Cardiac Death ◽  
Morphological Changes ◽  
Cytotoxic Action ◽  
Structural Components ◽  
Alcoholic Cardiomyopathy ◽  
Endothelial Lining ◽  
Gland Tissue ◽  
Thyroid Gland Tissue

A retrospective analysis of acts of forensic medical autopsies from the archive of St. Petersburg GBUS BSME and a histological study of thyroid gland tissue in 188 cases (95 women and 93 men) were carried out with statistical processing of the obtained results for the purpose of studying and assessing the morphological changes in the main components of the histohematological barrier of thyroid gland tissue in cases of the sudden cardiac death from alcoholic cardiomyopathy. The decrease in the weight of the thyroid gland in the investigated cases and the revealed morphological signs, indicative of a decrease in the memory function of the thyroid gland were found and can be caused by the prolonged toxic effect of ethanol and its metabolites. Morphological changes in the endothelial lining of the vessels of the microcirculatory bed are caused both by the direct cytotoxic action of ethanol and its metabolites and by the action of mediators, the release of which occurs as a result of stimulation of the reactive cells, which leads to swelling, deformation and increased activity of endothelial cell membranes with the expansion of intercellular spaces and the development of increased permeability of the endothelial lining, which, in its turn, contributes to disruption of electrolyte transport and nutrients transport with changes trophism thyroid gland tissue, which is a substrate for the appearance of dystrophic and necrobiotic processes in main structural components of the histogematogenous barrier of the thyroid gland. The revealed morphological changes in thyroid gland tissue in cases of death from alcoholic cardiomyopathy have a non-specific nature and should be considered in conjunction with other visceral manifestations that are a reflection of alcohol intoxication during the chronic alcoholism.

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