scholarly journals From pathways to people: applying the adverse outcome pathway (AOP) for skin sensitization to risk assessment

ALTEX ◽  
2013 ◽  
Vol 30 (4) ◽  
pp. 473-486 ◽  
Author(s):  
Cameron MacKay
Keyword(s):  
Risk Assessment ◽  
Adverse Outcome ◽  
Adverse Outcome Pathway ◽  
Skin Sensitization

Anchoring molecular mechanisms to the adverse outcome pathway for skin sensitization: Analysis of existing data

2014 ◽  
Vol 44 (7) ◽  
pp. 590-599 ◽  
Author(s):  
Jochem W. van der Veen ◽  
Lya G. Soeteman-Hernández ◽  
Janine Ezendam ◽  
Rob Stierum ◽  
Frieke C. Kuper ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Adverse Outcome ◽  
Adverse Outcome Pathway ◽  
Skin Sensitization ◽  
Existing Data

Leveraging human genetic and adverse outcome pathway (AOP) data to inform susceptibility in human health risk assessment

2018 ◽  
Vol 29 (1-2) ◽  
pp. 190-204 ◽  
Author(s):  
Holly M. Mortensen ◽  
John Chamberlin ◽  
Bonnie Joubert ◽  
Michelle Angrish ◽  
Nisha Sipes ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Health Risk ◽  
Human Health ◽  
Health Risk Assessment ◽  
Adverse Outcome ◽  
Human Health Risk ◽  
Human Health Risk Assessment ◽  
Adverse Outcome Pathway

scholarly journals Adverse Outcome Pathway Development for Assessment of Lung Carcinogenicity by Nanoparticles

2021 ◽  
Vol 3 ◽  
Author(s):  
Penny Nymark ◽  
Hanna L. Karlsson ◽  
Sabina Halappanavar ◽  
Ulla Vogel
Keyword(s):  
Lung Cancer ◽  
Risk Assessment ◽  
Adverse Outcome ◽  
Animal Experiments ◽  
Engineered Nanoparticles ◽  
Alternative Methods ◽  
Weight Of Evidence ◽  
Adverse Outcome Pathway ◽  
Alternative Mechanism

Lung cancer, one of the most common and deadly forms of cancer, is in some cases associated with exposure to certain types of particles. With the rise of nanotechnology, there is concern that some engineered nanoparticles may be among such particles. In the absence of epidemiological evidence, assessment of nanoparticle carcinogenicity is currently performed on a time-consuming case-by-case basis, relying mainly on animal experiments. Non-animal alternatives exist, including a few validated cell-based methods accepted for regulatory risk assessment of nanoparticles. Furthermore, new approach methodologies (NAMs), focused on carcinogenic mechanisms and capable of handling the increasing numbers of nanoparticles, have been developed. However, such alternative methods are mainly applied as weight-of-evidence linked to generally required animal data, since challenges remain regarding interpretation of the results. These challenges may be more easily overcome by the novel Adverse Outcome Pathway (AOP) framework, which provides a basis for validation and uptake of alternative mechanism-focused methods in risk assessment. Here, we propose an AOP for lung cancer induced by nanosized foreign matter, anchored to a selection of 18 standardized methods and NAMs for in silico- and in vitro-based integrated assessment of lung carcinogenicity. The potential for further refinement of the AOP and its components is discussed in relation to available nanosafety knowledge and data. Overall, this perspective provides a basis for development of AOP-aligned alternative methods-based integrated testing strategies for assessment of nanoparticle-induced lung cancer.

Application of the adverse outcome pathway framework for investigating skin sensitization potential of nanomaterials using new approach methods

2020 ◽  
Author(s):  
Soraia F. Bezerra ◽  
Bruna Santos Rodrigues ◽  
Artur C. G. Silva ◽  
Renato I. Ávila ◽  
Hallison R. G. Brito ◽  
...  
Keyword(s):  
Adverse Outcome ◽  
Adverse Outcome Pathway ◽  
Skin Sensitization ◽  
New Approach

scholarly journals Chemical exposure and infant leukaemia: development of an adverse outcome pathway (AOP) for aetiology and risk assessment research

2017 ◽  
Vol 91 (8) ◽  
pp. 2763-2780 ◽  
Author(s):  
Olavi Pelkonen ◽  
◽  
Andrea Terron ◽  
Antonio F. Hernandez ◽  
Pablo Menendez ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Adverse Outcome ◽  
Chemical Exposure ◽  
Adverse Outcome Pathway ◽  
Assessment Research

scholarly journals Application of the Adverse Outcome Pathway Framework to Risk Assessment for Predicting Carcinogenicity of Chemicals

2018 ◽  
Vol 23 (3) ◽  
pp. 126-133 ◽  
Author(s):  
Doo Seok Kang ◽  
Jun Hyuek Yang ◽  
Hyun Soo Kim ◽  
Bon Kon Koo ◽  
Cheol Min Lee ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Adverse Outcome ◽  
Adverse Outcome Pathway
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