Rescue fibrin glue-infiltrating hemostasis combined with hepatorrhaphy to control intractable postoperative bleeding from the liver cut surface

Endoscopic sinus surgery (ESS), especially when combined with turbinectomy and/or with submucous resection of the septum, may involve postoperative bleeding that might end with nasal packing. Nasal packing causes pain, rhinorrhea, and inconvenience and may not stop the postoperative bleeding. The aim of our study was to compare the hemostatic properties of the second-generation surgical sealant Quixil (Crosseal) with those of nasal packing in ESS. We performed a prospective randomized trial in 64 consecutive patients who underwent ESS and presented excessive intraoperative and/or postoperative bleeding. They were allocated by the sealed-envelope method into two groups. A routine ESS procedure was ended with Merocel nasal packing in group 1, and with aerosol application of Quixil sealant at the operative site in group 2. The hemostatic effects were evaluated objectively in the clinic by anterior rhinoscopy and endoscopy and assessed subjectively by the patients at follow-up visits. In group 1, various types of postoperative bleeding occurred in 25% of patients. In group 2 there was no postoperative bleeding, except for 1 case of late hemorrhage (3.12%). Drainage and ventilation of the paranasal sinuses were not impaired. There were no allergic reactions to the glue. We conclude that aerosol application of fibrin glue can be readily performed in ESS, requires no special treatment (antibiotics), and appears to have an adequate hemostatic effect. The use of this second-generation glue in ESS appears to stop nasal bleeding well and to be relatively safe and convenient.

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The efficacy of fibrin glue injection in the prostatic fossa on decreasing postoperative bleeding following transurethral resection of prostate

Advanced Biomedical Research ◽

10.4103/2277-9175.192733 ◽

2016 ◽

Vol 5 (1) ◽

pp. 161

Author(s):

Iman Ghanaat ◽

MohammadHatef Khorrami ◽

Farhad Tadaion ◽

Farshid Alizadeh

Keyword(s):

Fibrin Glue ◽

Transurethral Resection ◽

Postoperative Bleeding ◽

Transurethral Resection Of Prostate ◽

Prostatic Fossa ◽

Glue Injection

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Effectiveness of second-generation fibrin glue in endonasal operations

Otolaryngology ◽

10.1067/mhn.2002.123345 ◽

2002 ◽

Vol 126 (4) ◽

pp. 388-391 ◽

Cited By ~ 37

Author(s):

Michael Vaiman ◽

Ephraim Eviatar ◽

Samuel Segal

Keyword(s):

Fibrin Glue ◽

Fibrin Sealant ◽

Second Generation ◽

Postoperative Bleeding ◽

Nasal Packing ◽

Hemostatic Agent ◽

Efficacy And Safety ◽

Nasal Surgery ◽

Hemorrhagic Complications

We evaluated the efficacy and safety of the Quixil fibrin sealant after its application to endonasal operative sites. A total of 153 patients underwent nasal surgery. The rate of hemorrhagic complications was compared in the group with nasal packing and in the group in whom fibrin glue was used to stop postoperative bleeding. Our results indicate that the application of Quixil fibrin glue to the operative sites in various endonasal operations provides effective hemostasis and sealing. This fibrin glue is a more effective hemostatic agent than foam nasal packing and provides no complications, as can occur with packing. Patients with hypertension have no greater risk for postoperative bleeding if Quixil is used.

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Effect of Modern Fibrin Glue on Bleeding after Tonsillectomy and Adenoidectomy

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348940311200504 ◽

2003 ◽

Vol 112 (5) ◽

pp. 410-414 ◽

Cited By ~ 26

Author(s):

Michael Vaiman ◽

Nathan Shlamkovich ◽

Efraim Eviatar ◽

Samuel Segal

Keyword(s):

Blood Loss ◽

Fibrin Glue ◽

Randomized Study ◽

Postoperative Bleeding ◽

Postoperative Hemorrhage ◽

Control Group ◽

Surgical Trauma ◽

Intraoperative Blood Loss ◽

Secondary Hemorrhage ◽

Needle Point

We performed a prospective randomized study in 179 patients to examine the second-generation surgical fibrin sealant Quixil as an effective substitute for different types of electrocautery in tonsillectomy and adenoidectomy. We compared the rates of hemorrhagic complications in a group with bipolar or needle point electrocautery and in a group in whom fibrin glue was used to stop intraoperative bleeding and to prevent postoperative bleeding. The operations were performed under general anesthesia in typical fashion with sharp dissection. For the control group, hemostasis was achieved by bipolar or needle point electrocautery. For the fibrin glue group, hemostasis was achieved by spraying Quixil fibrin glue approximately 0.5 mL to each tonsillar fossa and 0.5 mL to the nasopharynx (in adenoidectomy). The results were excellent in all the patients of the fibrin glue group, with complete hemostasis and resolution of the major symptoms. In this group, the intraoperative blood loss averaged 15 mL in tonsillectomy and 9 mL in adenoidectomy. There were no cases of postoperative hemorrhage or any other complications. The electrocautery group required a longer time for healing, and its intraoperative blood loss (tonsillectomy) averaged 29 to 33 mL. The incidence of posttonsillectomy bleeding in this group was 4.35% (4 patients). Three patients (3.26%) had primary hemorrhage (bleeding that occurs within the first 24 hours of surgery), and 1 patient (1.09%) had secondary hemorrhage (bleeding that occurs after the first 24 hours). We conclude that Quixil fibrin glue application to the operative sites in tonsillectomy and adenoidectomy provides effective hemostasis and sealing with good systemic and local compatibility. With the help of Quixil, we minimized surgical trauma and achieved absolute hemostasis at the same time. We found this fibrin glue to be a more convenient and effective hemostatic sealant than bipolar or needle point coagulation.

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Inguinal hernia repair in patients with coagulation problems: Prevention of postoperative bleeding with human fibrin glue

Surgery ◽

10.1016/s0039-6060(99)70242-4 ◽

1999 ◽

Vol 125 (3) ◽

pp. 315-317 ◽

Cited By ~ 33

Author(s):

Silvestro Canonico ◽

Guido Sciaudone ◽

Fabio Pacifico ◽

Antonio Santoriello

Keyword(s):

Inguinal Hernia ◽

Hernia Repair ◽

Inguinal Hernia Repair ◽

Fibrin Glue ◽

Postoperative Bleeding ◽

Human Fibrin Glue

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Continuous venovenous hemodialysis (CVVHD) with citrate calcium reduces postoperative bleeding complications after cardiac surgery

The Thoracic and Cardiovascular Surgeon ◽

10.1055/s-0029-1246805 ◽

2010 ◽

Vol 58 (S 01) ◽

Author(s):

AH Kiessling ◽

F Isgro ◽

A Lehmann ◽

R Bergner ◽

M Neher ◽

...

Keyword(s):

Cardiac Surgery ◽

Postoperative Bleeding ◽

Bleeding Complications ◽

Continuous Venovenous Hemodialysis

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Stitchless Fibrin Glue-Aided Facial Nerve Grafting after Cerebellopontine Angle Schwannoma Removal: Technique and Results in 15 Cases

Journal of Neurological Surgery Part B Skull Base ◽

10.1055/s-0034-1384148 ◽

2014 ◽

Vol 75 (S 02) ◽

Author(s):

Vincent Darrouzet ◽

V. Franco-Vidal ◽

D. Liguoro

Keyword(s):

Facial Nerve ◽

Fibrin Glue ◽

Cerebellopontine Angle ◽

Nerve Grafting ◽

Removal Technique

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Effects on Coagulation and Fibrinolysis of Desmopressin in Patients Undergoing Total Hip Replacement

Thrombosis and Haemostasis ◽

10.1055/s-0038-1646480 ◽

1991 ◽

Vol 66 (06) ◽

pp. 652-656 ◽

Cited By ~ 7

Author(s):

Per Anders Flordal ◽

Karl-Gösta Ljungström ◽

Jan Svensson ◽

Brenda Ekman ◽

Gustaf Neander

Keyword(s):

Total Hip Replacement ◽

Hip Replacement ◽

Bleeding Time ◽

Antithrombin Iii ◽

Postoperative Bleeding ◽

Double Blind ◽

Total Hip ◽

Von Willebrand ◽

Willebrand Factor ◽

Coagulation And Fibrinolysis

SummaryTwelve patients undergoing total hip replacement, with regional anaesthesia and with dextran infusion for plasma expansion and thromboprophylaxis, were given the vasopressin analogue desmopressin (DDAVP) or placebo in a randomized, double-blind prospective study. In controls (n = 6) we found a prolongation of the bleeding time, low factor VIII (FVIII) and von Willebrand factor (vWF) and a decrease in antithrombin III to levels known to be at risk for venous thrombosis. Desmopressin shortened postoperative bleeding time, gave an early FVIII/vWF complex increase, prevented antithrombin III from falling to critically low values and appeared to activate the fibrinolytic system, both by tPA increase and PAI-1 decrease.Thus in the controls we found changes in both coagulation and fibrinolysis indicating a haemorrhagic diathesis as well as a risk for thromboembolism. Desmopressin induced factor changes that possibly reduce both risks.

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Major Surgery in a Subject with Factor V Deficiency

Thrombosis and Haemostasis ◽

10.1055/s-0038-1654318 ◽

1971 ◽

Vol 25 (03) ◽

pp. 438-446 ◽

Cited By ~ 10

Author(s):

E. J Melliger ◽

F Duckert

Keyword(s):

Intercellular Space ◽

Correct Diagnosis ◽

Postoperative Bleeding ◽

Major Surgery ◽

Factor V ◽

Factor V Deficiency ◽

Disappearance Time ◽

Fresh Plasma ◽

One Year

SummaryA further case of parahaemophilia is reported. One year after the correct diagnosis had been made the patient had to undergo cholecystectomy which was performed under prophylactic substitutive treatment with fresh plasma at a factor V level of 31 %. A minimal factor V level of 11 to 12% was maintained throughout the first week after operation. There was no abnormal postoperative bleeding. The half disappearance time of factor V was found to be about 12 h. Infusion of equivalent amounts of fresh plasma supplied a higher yield of factor V in the patient’s plasma before operation than postoperatively what may be explained by an increased diffusion of factor V into the intercellular space resulting from a postoperatively increased capillar permeability. The results are compared with those of other authors.

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