Abstract
Background: This study aimed to evaluate the surgical outcome and quality of life (QoL) of totally laparoscopic total gastrectomy (TLTG) compared with laparoscopy-assisted total gastrectomy (LATG) in patients with clinical stage I gastric cancer.Methods: From 2012 to 2018, EGC patients who underwent TLTG (n=223), including the first case with intracorporeal hemi-double stapling, were matched to those who underwent LATG (n=114) with extracorporeal circular stapling, using 2:1 propensity score matching (PSM). Prospectively collected morbidity was compared between the TLTG and LATG groups in conjunction with the learning curve. The European Organization for Research and Treatment of Cancer (EORTC) QoL questionnaires QLQ-C30, STO22, and OG25 were prospectively surveyed during postoperative 1 year for patient subgroups.Results: After PSM, grade I pulmonary complication rate was lower in the TLTG group (n=213) than in the LATG group (n=111) (0.5% vs. 5.4%, P=0.007). Other complications were not different between the groups. The learning curve of TLTG was overcome at the 26th case in terms of the comprehensive complication index. The TLTG group after learning curve showed lower grade I pulmonary complication rate than the matched LATG group (0.5% vs. 4.7%, P=0.024). Regarding postoperative QoL, the TLTG group (n=63) revealed less dysphagia (P=0.028), pain (P=0.028), eating restriction (P=0.006), eating (P=0.004), odynophagia (P=0.023) than the LATG group (n=21). Multivariate analyses for each QoL item demonstrated that TLTG was the only common independent factor for better QoL.Conclusions: TLTG reduced pulmonary complications and provided better QoL in dysphagia, pain, eating, odynophagia than LATG for patients with clinical stage I gastric cancer.
Multi-center comparative study between totally laparoscopic and robotic pancreaticoduodenectomy: Propensity score and learning curve matching analysis
