Long-term surgical outcomes of liver resection for hepatocellular carcinoma in patients with hepatitis B virus and hepatitis C virus co-infection: A multicenter observational study

Introduction:Hepatocellular carcinoma (HCC) is one of the most prevalent primary malignant tumors and accounts for about 90% of all primary liver cancers. Its distribution varies greatly according to geographic location and it is more common in middle and low- income countries than in developed ones especially in Eastern Asia and Sub Saharan Africa (70% of all new HCCs worldwide), with incidence rates of over 20 per 100,000 individuals.Explanation:The most important risk factors for HCC are Hepatitis B Virus (HBV) infection, Hepatitis C Virus (HCV) infection, excessive consumption of alcohol and exposition to aflatoxin B1. Its geographic variability and heterogeneity have been widely associated with the different distribution of HBV and HCV infections worldwide.Chronic HBV infection is one of the leading risk factors for HCC globally accounting for at least 50% cases of primary liver tumors worldwide. Generally, while HBV is the main causative agent in the high incidence HCC areas, HCV is the major etiological factor in low incidence HCC areas, like Western Europe and North America.Conclusion:HBV-induced HCC is a complex, stepwise process that includes integration of HBV DNA into host DNA at multiple or single sites. On the contrary, the cancerogenesis mechanism of HCV is not completely known and it still remains controversial as to whether HCV itself plays a direct role in the development of tumorigenic progression.

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Distinct expression patterns in hepatitis B virus- and hepatitis C virus-infected hepatocellular carcinoma

World Journal of Gastroenterology ◽

10.3748/wjg.14.6072 ◽

2008 ◽

Vol 14 (39) ◽

pp. 6072 ◽

Cited By ~ 22

Author(s):

Chun-Feng Lee ◽

Zhi-Qiang Ling ◽

Ting Zhao ◽

Kuan-Rong Lee

Keyword(s):

Hepatocellular Carcinoma ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Expression Patterns ◽

B Virus

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Association of Hepatocellular Carcinoma (HCC) With Hepatitis B Virus (HBV) Versus Hepatitis C Virus (HCV) Infection Among Different Asian Subgroups

Gastroenterology ◽

10.1016/s0016-5085(11)63835-3 ◽

2011 ◽

Vol 140 (5) ◽

pp. S-924-S-925 ◽

Cited By ~ 1

Author(s):

Hillary Lin ◽

Nghiem B. Ha ◽

Deawodi Ladzekpo ◽

Aijaz Ahmed ◽

Walid Ayoub ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Hcv Infection ◽

B Virus

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Statin and the risk of hepatocellular carcinoma in patients with hepatitis B virus or hepatitis C virus infection: a meta-analysis

BMC Gastroenterology ◽

10.1186/s12876-020-01222-1 ◽

2020 ◽

Vol 20 (1) ◽

Cited By ~ 1

Author(s):

Xiaofei Li ◽

Lina Sheng ◽

Liwen Liu ◽

Yongtao Hu ◽

Yongxin Chen ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Meta Analysis ◽

Hepatitis C Virus Infection ◽

B Virus

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Maternal Hepatitis B Virus or Hepatitis C Virus Carrier Status and Long-Term Endocrine Morbidity of the Offspring—A Population-Based Cohort Study

Journal of Clinical Medicine ◽

10.3390/jcm9030796 ◽

2020 ◽

Vol 9 (3) ◽

pp. 796 ◽

Cited By ~ 1

Author(s):

Naim Abu Freha ◽

Tamar Wainstock ◽

Tzvi Najman Menachem ◽

Eyal Sheiner

Keyword(s):

Cohort Study ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Hepatitis B Virus ◽

Hepatitis B ◽

Cox Regression ◽

Population Based ◽

Carrier Status ◽

B Virus

This study aimed to investigate the long-term effect of maternal hepatitis B virus (HBV) or hepatitis C virus (HCV) carrier status on offspring endocrine morbidity. A population-based cohort study included all singleton deliveries between the years 1991–2014 at the Soroka University Medical Center, Beer-Sheva, Southern Israel. The mothers were subdivided into three groups, HBV carriers, HCV carriers and non-carriers. Data regarding the long-term endocrine morbidity of their offspring were compared between the groups. The study included 242,905 (99.7%) non-carrying mothers, 591 (0.2%) mothers who were carriers for HBV and 186 (0.1%) mothers who were carriers for HCV. The Kaplan–Meier’s survival curve demonstrated a significantly higher cumulative endocrine morbidity in children born to mothers with HCV (log-rank test, p = 0.002). Specifically, higher rates of hypoglycemia were noted among the offspring born to mothers who were carriers of HCV (1.1%; p = 0.001) compared with the offspring of mothers who were either carriers of HBV (0.2%) or non-carriers (0.1%). A Cox regression model controlled for maternal age, gestational age, maternal diabetes, hypertensive disorders of pregnancy, found maternal HCV carrier status to be independently associated with pediatric endocrine morbidity in the offspring (adjusted hazard ratio = 5.05, 95% CI: 1.625–15.695, p = 0.005). Maternal HCV carrier status is an independent risk factor for long-term endocrine morbidity.

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