Epidermal Growth Factor (EGF) Promotes Human Malignant Glioma Invasion by Mediating Secretion of Human Cytomegalovirus Infected Monocyte-Derived Macrophages

2018 ◽  
Vol 3 ◽  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Malignant Glioma ◽  
Human Cytomegalovirus ◽  
Glioma Invasion ◽  
Human Malignant Glioma ◽  
Epidermal Growth

Intratumoral infusion of the monoclonal antibody, mAb 425, against the epidermal-growth-factor receptor in patients with advanced malignant glioma

1997 ◽  
Vol 44 (3) ◽  
pp. 157-164 ◽  
Author(s):  
P. Wersäll ◽  
I. Ohlsson ◽  
P. Biberfeld ◽  
V. P. Collins ◽  
S. von Krusenstjerna ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Malignant Glioma ◽  
Growth Factor Receptor ◽  
Epidermal Growth

scholarly journals Inhibition of epidermal growth factor receptor (EGFR) expression by human cytomegalovirus correlates with an increase in the expression and binding of Wilms' Tumour 1 protein to the EGFR promoter

2009 ◽  
Vol 90 (7) ◽  
pp. 1569-1574 ◽  
Author(s):  
Insiya Jafferji ◽  
Mark Bain ◽  
Christine King ◽  
John H. Sinclair
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Human Cytomegalovirus ◽  
Growth Factor Receptor ◽  
Cell Surface Receptor ◽  
Wilms Tumour ◽  
Promote Cell Proliferation ◽  
Egfr Expression ◽  
Epidermal Growth

Infection with human cytomegalovirus (HCMV) modulates the expression of a number of cellular receptors and is known to inhibit expression of the epidermal growth factor receptor (EGFR), a cell surface receptor that can promote cell proliferation through a cascade of intracellular signalling events. We have examined the mechanisms by which HCMV mediates downregulation of EGFR expression and show that virus infection results in the profound upregulation of Wilms' Tumour 1 (WT1) protein, a transcription factor associated with the negative regulation of a number of growth factors and growth factor receptors, including EGFR. Moreover, chromatin immunoprecipitation experiments also show that HCMV infection results in increased binding of WT1 to the EGFR promoter. Finally, we show that depleting the cell of WT1 using small interfering RNA abrogates virus-mediated downregulation of EGFR. Taken together, our observations suggest that HCMV-mediated repression of EGFR expression results from a virus-mediated increase in cellular WT1, a known pleiotropic regulator of mitogenesis, apoptosis and differentiation.

scholarly journals PI3K-Dependent Upregulation of Mcl-1 by Human Cytomegalovirus Is Mediated by Epidermal Growth Factor Receptor and Inhibits Apoptosis in Short-Lived Monocytes

2010 ◽  
Vol 184 (6) ◽  
pp. 3213-3222 ◽  
Author(s):  
Gary Chan ◽  
Maciej T. Nogalski ◽  
Gretchen L. Bentz ◽  
M. Shane Smith ◽  
Alexander Parmater ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Human Cytomegalovirus ◽  
Growth Factor Receptor ◽  
Epidermal Growth

Mechanisms of human cytomegalovirus infection with a focus on epidermal growth factor receptor interactions

2017 ◽  
Vol 27 (6) ◽  
pp. e1955 ◽  
Author(s):  
Aline Semblano Carreira Falcão ◽  
Pedro Fernando da Costa Vasconcelos ◽  
Dorotéa de Fátima Lobato da Silva ◽  
João de Jesus Viana Pinheiro ◽  
Luiz Fábio Magno Falcão ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Human Cytomegalovirus ◽  
Cytomegalovirus Infection ◽  
Growth Factor Receptor ◽  
Receptor Interactions ◽  
Epidermal Growth ◽  
Human Cytomegalovirus Infection

Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium

1990 ◽  
Vol 73 (1) ◽  
pp. 106-112 ◽  
Author(s):  
Ian F. Pollack ◽  
Margaret S. Randall ◽  
Matthew P. Kristofik ◽  
Robert H. Kelly ◽  
Robert G. Selker ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Malignant Glioma ◽  
Cell Lines ◽  
Glioma Cell ◽  
Platelet Derived Growth Factor ◽  
Glial Tumors ◽  
Serum Free ◽  
Glioma Cell Lines ◽  
Epidermal Growth

✓ The use of a serum-free culture system for assessing the growth factor responsiveness of malignant glial cells is described. The mitogenic properties of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) were examined in three human malignant glioma cell lines (T98G, U87, and U138). Each of the three had high-affinity EGF receptors and all responded in a dose-dependent fashion to physiological concentrations of EGF. These cell lines also showed a pronounced mitogenic response to PDGF which equaled or exceeded that achieved with EGF. Simultaneous stimulation with both factors produced an additive response, which approximated that obtained in medium supplemented with 10% fetal calf serum. The authors conclude that functional EGF and PDGF receptors were present in the human malignant glial tumors studied. The response of the human glioma lines to these growth factors in many respects parallels the response seen in fetal astrocytes tested under similar conditions. In contrast, the behavior of two chemically induced rat gliomas (9L and C6) differed significantly from that seen in the human lines, suggesting that the rat lines may not be entirely acceptable as models for studying the growth characteristics of human malignant glial tumors.

Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus

Nature ◽  
2003 ◽  
Vol 424 (6947) ◽  
pp. 456-461 ◽  
Author(s):  
Xin Wang ◽  
Shu-Mei Huong ◽  
Marie L. Chiu ◽  
Nancy Raab-Traub ◽  
Eng-Shang Huang
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Human Cytomegalovirus ◽  
Growth Factor Receptor ◽  
Cellular Receptor ◽  
Epidermal Growth
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