scholarly journals A 1 week IGF-1 infusion decreases arterial insulin concentrations but increases pancreatic insulin content and islet vascularity in fetal sheep

2018 ◽  
Vol 6 (17) ◽  
pp. e13840 ◽  
Author(s):  
Alicia White ◽  
Samantha Louey ◽  
Eileen I Chang ◽  
Brit H. Boehmer ◽  
David Goldstrohm ◽  
...  
Keyword(s):  
Insulin Content ◽  
Fetal Sheep ◽  
Pancreatic Insulin ◽  
Pancreatic Insulin Content ◽  
Arterial Insulin

Insulin release and pancreatic insulin is reduced in young prediabetic BB rats

1986 ◽  
Vol 112 (3) ◽  
pp. 367-371 ◽  
Author(s):  
Annette Svenningsen ◽  
Thomas Dyrberg ◽  
Helle Markholst ◽  
Christian Binder ◽  
Åke Lernmark
Keyword(s):  
Insulin Release ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Content ◽  
Dependent Diabetes Mellitus ◽  
Clinical Onset ◽  
Pancreatic Insulin ◽  
Pancreatic Insulin Content ◽  
Bb Rats ◽  
Insulin Dependent ◽  
The Mean

Abstract. The pancreases of approximately 50 days old diabetes-prone BB/Hagedorn (BB/H) and of the genetically closely related, but non-diabetic BB w-subline (control BB) rats were perfused to determine the capacity of D-glucose to release insulin before the expected development of diabetes. The BB/H rats were from a colony with 82–84% incidence of insulin-dependent diabetes mellitus (IDDM) by 140 days of age. The total amount of insulin released from the BB/H rat pancreas during stimulation with 20 mmol/l D-glucose was reduced by nearly 50% (P <0.01). The initial peak of insulin release was similar between the two groups of animals, whereas the amount of insulin released during the second peak accounted for the diminished release (P < 0.01). The extractable pancreatic insulin was 30% (P < 0.05) less in the BB/H rats. Total insulin release expressed relative to the pancreatic insulin content, was therefore not different between the two groups. It is concluded that about 20–40 days before the mean age of clinical onset of IDDM in BB/H rats, the capacity to release insulin in response to D-glucose is reduced along with a diminished pancreatic insulin content. This abnormality seems to be preceded only by islet cell surface antibodies but not by insulitis.

scholarly journals Pancreatic Insulin Content Regulation by the Estrogen Receptor ERα

PLoS ONE ◽  
2008 ◽  
Vol 3 (4) ◽  
pp. e2069 ◽  
Author(s):  
Paloma Alonso-Magdalena ◽  
Ana B. Ropero ◽  
M. Pilar Carrera ◽  
Christopher R. Cederroth ◽  
Mathurin Baquié ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Insulin Content ◽  
Pancreatic Insulin ◽  
Pancreatic Insulin Content ◽  
Content Regulation

Pancreatic Insulin Content of Nonpregnant, Pregnant and Postpartum Rats and the Developing Rat Fetus

Diabetes ◽  
1969 ◽  
Vol 18 (5) ◽  
pp. 268-272 ◽  
Author(s):  
S. Rishi ◽  
E. K. Golob ◽  
K. L. Becker ◽  
N. Shah
Keyword(s):  
Insulin Content ◽  
Rat Fetus ◽  
Pancreatic Insulin ◽  
Pancreatic Insulin Content ◽  
Developing Rat

Marked reduction of pancreatic insulin content in male ventromedial hypothalamic-lesioned spontaneously non-insulin-dependent diabetic (Goto-Kakizaki) rats

Metabolism ◽  
1994 ◽  
Vol 43 (1) ◽  
pp. 32-37 ◽  
Author(s):  
Yoshiaki Keno ◽  
Katsuto Tokunaga ◽  
Shigenori Fujioka ◽  
Takashi Kobatake ◽  
Kazuaki Kotani ◽  
...  
Keyword(s):  
Marked Reduction ◽  
Insulin Content ◽  
Pancreatic Insulin ◽  
Pancreatic Insulin Content ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

scholarly journals Effect of Mesoxalate on Pancreatic Insulin Content in Rats and Dogs

1958 ◽  
Vol 34 (6) ◽  
pp. 387-390
Author(s):  
Setsuya TAKEUCHI ◽  
Shigeru OHASHI
Keyword(s):  
Insulin Content ◽  
Pancreatic Insulin ◽  
Pancreatic Insulin Content
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