scholarly journals Is there hope that transpinal direct current stimulation corrects motoneuron excitability and provides neuroprotection in amyotrophic lateral sclerosis?

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Marcin Bączyk ◽  
Piotr Krutki ◽  
Daniel Zytnicki
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Direct Current ◽  
Direct Current Stimulation ◽  
Motoneuron Excitability ◽  
Lateral Sclerosis

Remotely supervised transcranial direct current stimulation: A feasibility study for amyotrophic lateral sclerosis

2019 ◽  
Vol 45 (3) ◽  
pp. 369-378 ◽  
Author(s):  
Anjali Sivaramakrishnan ◽  
Abhishek Datta ◽  
Marom Bikson ◽  
Sangeetha Madhavan
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Feasibility Study ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation ◽  
Lateral Sclerosis

Motor cortex abnormalities in amyotrophic lateral sclerosis with transcranial direct-current stimulation

2007 ◽  
Vol 35 (5) ◽  
pp. 620-624 ◽  
Author(s):  
Angelo Quartarone ◽  
Nicolas Lang ◽  
Vincenzo Rizzo ◽  
Sergio Bagnato ◽  
Francesca Morgante ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation ◽  
Lateral Sclerosis

scholarly journals Transcranial direct current stimulation does not modulate motor cortex excitability in patients with amyotrophic lateral sclerosis

2011 ◽  
Vol 44 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Moniek A.M. Munneke ◽  
Dick F. Stegeman ◽  
Yvonne A. Hengeveld ◽  
Jan J. Rongen ◽  
H. Jurgen Schelhaas ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation ◽  
Motor Cortex Excitability ◽  
Lateral Sclerosis

Direct Current Motor Cortex Stimulation for Amyotrophic Lateral Sclerosis: A Proof of Principle Study

2013 ◽  
Vol 6 (6) ◽  
pp. 969-970 ◽  
Author(s):  
Vincenzo Di Lazzaro ◽  
Federico Ranieri ◽  
Fioravante Capone ◽  
Gabriella Musumeci ◽  
Michele Dileone
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Cortex ◽  
Direct Current ◽  
Motor Cortex Stimulation ◽  
Direct Current Motor ◽  
Lateral Sclerosis ◽  
Proof Of Principle

Automated Acoustic Analysis of Oral Diadochokinesis to Assess Bulbar Motor Involvement in Amyotrophic Lateral Sclerosis

2020 ◽  
Vol 63 (1) ◽  
pp. 59-73 ◽  
Author(s):  
Panying Rong
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Acoustic Analysis ◽  
Speaking Rate ◽  
Disease Stage ◽  
Healthy Controls ◽  
Tongue Movement ◽  
Major Barrier ◽  
Syllable Repetition ◽  
Oral Diadochokinesis ◽  
Lateral Sclerosis

Purpose The purpose of this article was to validate a novel acoustic analysis of oral diadochokinesis (DDK) in assessing bulbar motor involvement in amyotrophic lateral sclerosis (ALS). Method An automated acoustic DDK analysis was developed, which filtered out the voice features and extracted the envelope of the acoustic waveform reflecting the temporal pattern of syllable repetitions during an oral DDK task (i.e., repetitions of /tɑ/ at the maximum rate on 1 breath). Cycle-to-cycle temporal variability (cTV) of envelope fluctuations and syllable repetition rate (sylRate) were derived from the envelope and validated against 2 kinematic measures, which are tongue movement jitter (movJitter) and alternating tongue movement rate (AMR) during the DDK task, in 16 individuals with bulbar ALS and 18 healthy controls. After the validation, cTV, sylRate, movJitter, and AMR, along with an established clinical speech measure, that is, speaking rate (SR), were compared in their ability to (a) differentiate individuals with ALS from healthy controls and (b) detect early-stage bulbar declines in ALS. Results cTV and sylRate were significantly correlated with movJitter and AMR, respectively, across individuals with ALS and healthy controls, confirming the validity of the acoustic DDK analysis in extracting the temporal DDK pattern. Among all the acoustic and kinematic DDK measures, cTV showed the highest diagnostic accuracy (i.e., 0.87) with 80% sensitivity and 94% specificity in differentiating individuals with ALS from healthy controls, which outperformed the SR measure. Moreover, cTV showed a large increase during the early disease stage, which preceded the decline of SR. Conclusions This study provided preliminary validation of a novel automated acoustic DDK analysis in extracting a useful measure, namely, cTV, for early detection of bulbar ALS. This analysis overcame a major barrier in the existing acoustic DDK analysis, which is continuous voicing between syllables that interferes with syllable structures. This approach has potential clinical applications as a novel bulbar assessment.

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