scholarly journals Transcriptomic analysis of cardiac gene expression across the life course in male and female mice

2021 ◽  
Vol 9 (13) ◽  
Author(s):  
Aykhan Yusifov ◽  
Vikram E. Chhatre ◽  
Eva K. Koplin ◽  
Cortney E. Wilson ◽  
Emily E. Schmitt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Life Course ◽  
Transcriptomic Analysis ◽  
Male And Female ◽  
Female Mice ◽  
Cardiac Gene Expression ◽  
Cardiac Gene ◽  
The Life Course

scholarly journals Transcriptomic Analysis Of Cardiac Gene Expression Across The Life‐Course In Male And Female Mice

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Aykhan Yusifov ◽  
Vikram Chhatre ◽  
Eva Koplin ◽  
Emily Schmitt ◽  
Kathleen Woulfe ◽  
...  
Keyword(s):  
Gene Expression ◽  
Life Course ◽  
Transcriptomic Analysis ◽  
Male And Female ◽  
Female Mice ◽  
Cardiac Gene Expression ◽  
Cardiac Gene ◽  
The Life Course

scholarly journals Newborn DNA-methylation, childhood lung function, and the risks of asthma and COPD across the life course

2019 ◽  
Vol 53 (4) ◽  
pp. 1801795 ◽  
Author(s):  
Herman T. den Dekker ◽  
Kimberley Burrows ◽  
Janine F. Felix ◽  
Lucas A. Salas ◽  
Ivana Nedeljkovic ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Function ◽  
Life Course ◽  
Cord Blood ◽  
Childhood Asthma ◽  
Respiratory Health ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
The Life Course

RationaleWe aimed to identify differentially methylated regions (DMRs) in cord blood DNA associated with childhood lung function, asthma and chronic obstructive pulmonary disease (COPD) across the life course.MethodsWe meta-analysed epigenome-wide data of 1688 children from five cohorts to identify cord blood DMRs and their annotated genes, in relation to forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC) ratio and forced expiratory flow at 75% of FVC at ages 7–13 years. Identified DMRs were explored for associations with childhood asthma, adult lung function and COPD, gene expression and involvement in biological processes.ResultsWe identified 59 DMRs associated with childhood lung function, of which 18 were associated with childhood asthma and nine with COPD in adulthood. Genes annotated to the top 10 identified DMRs were HOXA5, PAOX, LINC00602, ABCA7, PER3, CLCA1, VENTX, NUDT12, PTPRN2 and TCL1A. Differential gene expression in blood was observed for 32 DMRs in childhood and 18 in adulthood. Genes related with 16 identified DMRs were associated with respiratory developmental or pathogenic pathways.InterpretationOur findings suggest that the epigenetic status of the newborn affects respiratory health and disease across the life course.

scholarly journals Doppler Echocardiographic Assessment and Cardiac Gene Expression Analysis of the Left Ventricle in Myocardial lnfarcted Rats

1998 ◽  
Vol 62 (6) ◽  
pp. 436-442 ◽  
Author(s):  
Naruhito Shimizu ◽  
Minoru Yoshiyama ◽  
Kazuhide Takeuchi ◽  
Akihisa Hanatani ◽  
Shokei Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Left Ventricle ◽  
Expression Analysis ◽  
Gene Expression Analysis ◽  
Cardiac Gene Expression ◽  
Cardiac Gene ◽  
Echocardiographic Assessment

scholarly journals Myocardin Marks the Earliest Cardiac Gene Expression and Plays an Important Role in Heart Development

2008 ◽  
Vol 291 (10) ◽  
pp. 1200-1211 ◽  
Author(s):  
Jian-Fu Chen ◽  
Shusheng Wang ◽  
Qiulian Wu ◽  
Dongsun Cao ◽  
Thiha Nguyen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heart Development ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

Abstract 247: Scaffold-stiffness Dependent Notch1 Activation Regulates Cardiogenic Gene Expression In Cardiac Progenitor Cells

2013 ◽  
Vol 113 (suppl_1) ◽  
Author(s):  
Archana V Boopathy ◽  
Pao L Che ◽  
Yoshie Narui ◽  
Khalid Salaita ◽  
Michael E Davis
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Cardiac Function ◽  
Progenitor Cells ◽  
Adult Stem Cells ◽  
Cardiac Progenitor Cells ◽  
Critical Pathway ◽  
Cardiac Gene Expression ◽  
Self Assembling ◽  
Cardiac Gene

Rationale: Cardiac progenitor cells (CPCs) are multipotent, self-renewing cells that can regenerate the myocardium and improve cardiac function in animal models of myocardial infarction (MI). However, limited survival of stem/progenitor cells inhibits cardiac regeneration. Force dependent Notch activation promotes cardiac development and cardiac gene expression in many adult stem cells. As dysregulation of Notch signaling leads to embryonic lethal cardiovascular defects, activating this critical pathway during cell transplantation could improve efficacy of stem cell therapy. Objective: Investigate i) whether self-assembling peptide scaffolds can be used to activate Notch1 signaling in CPCs to promote cardiogenic differentiation and ii) the effect of scaffold stiffness on Notch1 activation and differentiation. Methods: Rat CPCs (c-kit + ) were cultured for 48h in 3D self-assembling scaffolds of varying stiffness (1% low, 2% high): empty scaffolds (RADA), scaffolds modified with peptide mimicking Notch1 ligand, Jagged1 (RJAG), or scaffolds modified with a scrambled peptide (RSCR) and cardiogenic gene expression measured by qRT-PCR. CHO cells expressing Notch1 responsive YFP were also cultured in the above scaffolds for 48h and YFP expression was determined. Results are mean ± SEM with p<0.05 considered significant by one or two-way ANOVA with appropriate post test. Results: In the Notch1 reporter cells, Notch1 activation increased significantly in presence of RJAG (p<0.01) and on increasing scaffold stiffness (p<0.01,n=6) indicating scaffold stiffness-dependent Notch1 activation. Culture of CPCs in RJAG containing 1% scaffolds (low stiffness) significantly increased early endothelial and smooth muscle but not cardiac gene expression while in 2% scaffolds (high stiffness) significantly increased only cardiac and not endothelial or smooth muscle gene expression (p<0.05, n≥4). Conclusions: Taken together, these data show that i) Notch1 activation in 3D is dependent on ligand density and scaffold stiffness and ii) stiffness dependent Notch1 activation differentially regulates cardiogenic gene expression in CPCs. Therefore, delivery of CPCs in JAG containing scaffolds could be used to improve cardiac function following MI.

scholarly journals Corrigendum to “Tbx5-dependent rheostatic control of cardiac gene expression and morphogenesis” [Dev. Biol. 297 (2006) 566–586]

2007 ◽  
Vol 309 (2) ◽  
pp. 386
Author(s):  
Allesandro D. Mori ◽  
Yonghong Zhu ◽  
Ilyas Vahora ◽  
Brian Nieman ◽  
Kazuko Koshiba-Takeuchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

Multifactorial Regulation of Cardiac Gene Expression: an In Vivo and In Vitro Analysis

1995 ◽  
Vol 752 (1 Cardiac Growt) ◽  
pp. 370-386 ◽  
Author(s):  
J. L. SAMUEL ◽  
I. DUBUS ◽  
F. FARHADIAN ◽  
F. MAROTTE ◽  
P. OLIVIERO ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cardiac Gene Expression ◽  
Cardiac Gene ◽  
Vitro Analysis ◽  
In Vitro Analysis

scholarly journals Transcription factor-induced activation of cardiac gene expression in human c-kit+ cardiac progenitor cells

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0174242 ◽  
Author(s):  
Tareq Al-Maqtari ◽  
Kyung U. Hong ◽  
Bathri N. Vajravelu ◽  
Afsoon Moktar ◽  
Pengxiao Cao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Progenitor Cells ◽  
Cardiac Progenitor Cells ◽  
Cardiac Gene Expression ◽  
Cardiac Gene

scholarly journals Adenosine-Induced Cardiac Gene Expression of Ischemic Murine Hearts Revealed by cDNA Array Hybridization

2002 ◽  
Vol 66 (1) ◽  
pp. 93-93 ◽  
Author(s):  
Masanori Asakura ◽  
Masafumi Kitakaze ◽  
Yasuhiko Sakata ◽  
Hiroshi Asanuma ◽  
Shoji Sanada ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cdna Array ◽  
Cardiac Gene Expression ◽  
Cardiac Gene ◽  
Array Hybridization
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