scholarly journals Plasma disappearance half-time and metabolic clearance rate of exogenous human growth hormone-releasing hormone-(1-44)-NH2 in normal subjects.

1986 ◽  
Vol 33 (6) ◽  
pp. 875-881 ◽  
Author(s):  
YASUHIKO OKIMURA ◽  
KAZUO CHIHARA ◽  
HIROMI ABE ◽  
HIDESUKE KAJI ◽  
HITOSHI KODAMA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Clearance Rate ◽  
Human Growth ◽  
Normal Subjects ◽  
Metabolic Clearance ◽  
Growth Hormone Releasing Hormone ◽  
Half Time ◽  
Metabolic Clearance Rate ◽  
Releasing Hormone

The metabolic clearance rate, serum half-time and apparent distribution space of authentic biosynthetic human growth hormone in growth hormone-deficient patients

1989 ◽  
Vol 120 (1) ◽  
pp. 8-13 ◽  
Author(s):  
J. O. L. Jørgensen ◽  
A. Flyvbjerg ◽  
J. S. Christiansen
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Clearance Rate ◽  
Human Growth ◽  
Metabolic Clearance ◽  
Half Time ◽  
Distribution Space ◽  
Metabolic Clearance Rate ◽  
Apparent Distribution ◽  
Observation Period

Abstract. We studied the metabolic clearance rate (MCR) serum half-time (t½) and apparent distribution space (DS) of unlabelled, authentic, biosynthetic human growth hormone (B-hGH) in 9 GH-deficient patients by means of the constant iv infusion to equilibrium technique. B-hGH was infused for 3 h at a rate of 33 ng · kg−1 · min−1 after which the disappearance from serum of GH was followed for 1 h. The mean ± sem values for MCR, t½ and DS were: 2.3 ± 0.6 ml · kg−1 · min−1, 21.1 ± 1.7 min and 67.6 ± 14.6 ml/kg, respectively. The disappearance of GH was monoexponential for the first 30 min, during which 75% of the GH had been cleared. The disappearance rate during the last 30 min of the observation period was somewhat lower, still approximately 90% of the GH had been eliminated after 60 min.

scholarly journals Metabolic clearance rate of radioiodinated human growth hormone in man

1969 ◽  
Vol 48 (9) ◽  
pp. 1600-1608 ◽  
Author(s):  
Donald P. Cameron ◽  
Henry G. Burger ◽  
Kevin J. Catt ◽  
Alison Doig
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Clearance Rate ◽  
Human Growth ◽  
Metabolic Clearance ◽  
Metabolic Clearance Rate

scholarly journals Tissue-specific molecular heterogeneity of human growth hormone-releasing hormone receptor protein

FEBS Letters ◽  
1996 ◽  
Vol 394 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Yuichi Fujinaka ◽  
Yutaka Yokogoshi ◽  
Chen-Yu Zhang ◽  
Toshihiro Okura ◽  
Kouki Kitagawa ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Hormone Receptor ◽  
Human Growth ◽  
Receptor Protein ◽  
Molecular Heterogeneity ◽  
Growth Hormone Releasing Hormone ◽  
Tissue Specific ◽  
Releasing Hormone
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