scholarly journals Nitric oxide: link between endothelial dysfunction and inflammation in patients with peripheral arterial disease of the lower limbs☆

2009 ◽  
Vol 9 (1) ◽  
pp. 107-112 ◽  
Author(s):  
Joaquin de Haro Miralles ◽  
Esther Martínez-Aguilar ◽  
Aurora Florez ◽  
César Varela ◽  
Silvia Bleda ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Lower Limbs ◽  
Peripheral Arterial

Safety of 60-day l-arginine supplementation of patients with peripheral arterial disease of lower limbs

2015 ◽  
Vol 67 ◽  
pp. 16
Author(s):  
Natasza Balcer-Dymel ◽  
Katarzyna Korzeniowska ◽  
Artur Cieślewicz ◽  
Anna Jabłecka
Keyword(s):  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Lower Limbs ◽  
Peripheral Arterial ◽  
Arginine Supplementation

scholarly journals Association of Carboxyhemoglobin Levels with Peripheral Arterial Disease in Chronic Smokers Managed at Dr George Mukhari Academic Hospital

2020 ◽  
Vol 17 (15) ◽  
pp. 5581
Author(s):  
Mashudu Nemukula ◽  
Motetelo Alfred Mogale ◽  
Honey Bridget Mkhondo ◽  
Lizette Bekker
Keyword(s):  
Nitric Oxide ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Academic Hospital ◽  
Convenience Sample ◽  
Logistic Analysis ◽  
Arterial Dilation ◽  
Peripheral Arterial ◽  
Arterial Damage ◽  
Multivariate Logistic Analysis

Chronic cigarette smokers (CCS) are known to have elevated levels of carboxyhemoglobin (COHb). However, it is not known whether increased levels of COHb are associated with endothelial dysfunction (ED), and therefore the development of peripheral arterial disease (PAD). The aim of the study was to investigate the association of blood COHb and plasma nitric oxide (NO) levels, and whether it is an independent risk factor in the development of PAD among CCS at Dr George Mukhari Academic Hospital (DGMAH). A sample of 120 CCS with PAD and a convenience sample of 100 CCS without PAD were recruited into the study. Blood COHb levels were measured using the ABL 90 FLEX CO-oximeter automated spectroscopy. Plasma nitric oxide (NO) levels were measure using ELISA. Logistic regression analysis was used to investigate the association of blood COHb and plasma NO with PAD. Blood COHb levels of CCS with PAD were significantly higher than those of CCS without PAD, and the NO levels of CCS with PAD were significantly lower than those of CCS without PAD. Although both the blood COHb and plasma NO in CCS were significantly associated with PAD in bivariate logistic analysis, only plasma NO was independently associated with PAD in multivariate logistic analysis. This finding is consistent with the hypothesis that COHb is a cause of arterial damage in PAD, leading to reduced NO, and therefore reduced arterial dilation.

scholarly journals Use of hyperspectral imaging to assess endothelial dysfunction in peripheral arterial disease

2016 ◽  
Vol 64 (4) ◽  
pp. 1066-1073 ◽  
Author(s):  
Brandon J. Sumpio ◽  
Gianluca Citoni ◽  
Jason A. Chin ◽  
Bauer E. Sumpio
Keyword(s):  
Endothelial Dysfunction ◽  
Peripheral Arterial Disease ◽  
Hyperspectral Imaging ◽  
Arterial Disease ◽  
Peripheral Arterial
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