Effect of 8-day therapy with propionyl-L-carnitine on muscular and subcutaneous blood flow of the lower limbs in patients with peripheral arterial disease

1995 ◽  
Vol 15 (5) ◽  
pp. 417-423 ◽  
Author(s):  
M. Bolognesi ◽  
P. Amodio ◽  
C. Merkel ◽  
L. Godi ◽  
A. Gatta
Keyword(s):  
Blood Flow ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Lower Limbs ◽  
Subcutaneous Blood Flow ◽  
Peripheral Arterial

Pulmonary V̇o2 dynamics during treadmill and arm exercise in peripheral arterial disease

2004 ◽  
Vol 97 (2) ◽  
pp. 627-634 ◽  
Author(s):  
Timothy A. Bauer ◽  
Eric P. Brass ◽  
Mark Nehler ◽  
Thomas J. Barstow ◽  
William R. Hiatt
Keyword(s):  
Blood Flow ◽  
Peripheral Arterial Disease ◽  
Treadmill Exercise ◽  
Arterial Disease ◽  
Occlusive Disease ◽  
Lower Limbs ◽  
Whole Body ◽  
Moderate Intensity ◽  
Arm Exercise ◽  
Peripheral Arterial

Slowed pulmonary O2 uptake (V̇o2) kinetics in peripheral arterial disease (PAD) have been attributed to impaired limb blood flow and/or peripheral muscle metabolic abnormalities. Although PAD results from atherosclerotic occlusive disease in the arteries to the lower extremities, systemic abnormalities affecting whole body O2 delivery or vascular function in PAD could also partially explain the exercise impairment. To date, the effects of these systemic abnormalities have not been evaluated. To test the hypothesis that the slowed pulmonary V̇o2 kinetics in PAD reflects local and not systemic abnormalities, V̇o2 kinetics were evaluated after the onset of constant-load exercise of the upper and lower limbs in PAD patients and healthy controls (Con). Ten PAD patients and 10 Con without significant cardiopulmonary dysfunction performed multiple transitions from rest to moderate-intensity arm ergometry and treadmill exercise to assess their V̇o2 kinetic responses. Reactive hyperemic (RH) blood flow was assessed in the arms and legs as a measure of endothelial function. Compared with Con, PAD V̇o2 kinetic phase 2 time constants were prolonged during treadmill exercise (PAD 34.3 ± 9.2 s vs. Con 19.6 ± 3.5 s; P < 0.01) but not arm exercise (PAD 38.5 ± 7.5 s vs. Con 32.5 ± 9.0 s; P > 0.05). RH blood flow was significantly reduced in the legs (PAD 20.7 ± 8.3 vs. Con 46.1 ± 17.1 ml·100 ml−1·min−1; P < 0.01) and arms of PAD subjects (PAD 34.0 ± 8.6 vs. Con 50.8 ± 12.2 ml·100 ml−1·min−1; P < 0.01) compared with Con, but RH limb flow was not correlated with arm or treadmill V̇o2 kinetic responses in either group. In summary, slowed pulmonary V̇o2 kinetics in PAD patients occur only with exercise of the lower limbs affected by the arterial occlusive disease process and are not slowed with exercise of the unaffected upper extremities compared with controls. Furthermore, the slowed pulmonaryV̇o2 kinetics of the lower extremity could not be explained by any abnormalities in resting cardiac or pulmonary function and were not related to the magnitude of reduction in limb vascular reactivity.

scholarly journals Hallucal thenar index: A new index to detect peripheral arterial disease using laser speckle flowgraphy

Vascular ◽  
2020 ◽  
pp. 170853812093893
Author(s):  
Kazuhiro Tsunekawa ◽  
Fumio Nagai ◽  
Tamon Kato ◽  
Ikkei Takashimizu ◽  
Daisuke Yanagisawa ◽  
...  
Keyword(s):  
Blood Flow ◽  
Peripheral Arterial Disease ◽  
Operating Characteristic ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Skin Perfusion ◽  
Peripheral Arterial ◽  
Cutaneous Blood

Objectives Laser speckle flowgraphy is a technology using reflected scattered light for visualization of blood distribution, which can be used to measure relative velocity of blood flow easily without contact with the skin within a short time. It was hypothesized that laser speckle flowgraphy may be able to identify foot ischemia. This study was performed to determine whether laser speckle flowgraphy could distinguish between subjects with and without peripheral arterial disease. Materials and methods All subjects were classified based on clinical observations using the Rutherford classification: non-peripheral arterial disease, class 0; peripheral arterial disease group, class 2–5. Rutherford class 6 was one of the exclusion criteria. Laser speckle flowgraphy measured the beat strength of skin perfusion as an indicator of average dynamic cutaneous blood flow change synchronized with the heartbeat. The beat strength of skin perfusion indicates the strength of the heartbeat on the skin, and the heartbeat strength calculator in laser speckle flowgraphy uses the blood flow data to perform a Fourier transform to convert the temporal changes in blood flow to a power spectrum. A total of 33 subjects with peripheral arterial disease and 40 subjects without peripheral arterial disease at a single center were prospectively examined. Laser speckle flowgraphy was used to measure hallucal and thenar cutaneous blood flow, and the measurements were repeated three times. The hallucal and thenar index was defined as the ratio of beat strength of skin perfusion value on hallux/beat strength of skin perfusion value on ipsilateral thenar eminence. The Mann–Whitney U-test was used to compare the median values of hallucal and thenar index and ankle brachial index between the two groups. A receiver operating characteristic curve for hallucal and thenar index of beat strength of skin perfusion was plotted, and a cutoff point was set. The correlation between hallucal and thenar index of beat strength of skin perfusion and ankle brachial index was explored in all subjects, the hemodialysis group, and the non-hemodialysis (non-hemodialysis) group. Results The median value of the hallucal and thenar index of beat strength of skin perfusion was significantly different between subjects with and without peripheral arterial disease (0.27 vs. 0.87, respectively; P <  0.001). The median value of ankle brachial index was significantly different between subjects with and without peripheral arterial disease (0.8 vs. 1.1, respectively; P <  0.001). Based on the receiver operating characteristic of hallucal and thenar index, the cutoff was 0.4416 and the sensitivity, specificity, positive predictive value, and negative predictive value were 68.7%, 95%, 91.7%, and 77.6%, respectively. The correlation coefficients of all subjects, the hemodialysis group, and the non-hemodialysis group were 0.486, 0.102, and 0.743, respectively. Conclusions Laser speckle flowgraphy is a noninvasive, rapid, and widely applicable method. Laser speckle flowgraphy using hallucal and thenar index would be helpful to determine the differences between subjects with and without peripheral arterial disease. The correlation between hallucal and thenar index of beat strength of skin perfusion and ankle brachial index indicated that this index was especially useful in the non-hemodialysis group.

scholarly journals Laser Doppler blood flowmeter as a useful instrument for the early detection of lower extremity peripheral arterial disease in hemodialysis patients: an observational study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Takeo Ishii ◽  
Shizuka Takabe ◽  
Yuki Yanagawa ◽  
Yuko Ohshima ◽  
Yasuhiro Kagawa ◽  
...  
Keyword(s):  
Blood Flow ◽  
Peripheral Arterial Disease ◽  
Early Stage ◽  
Arterial Disease ◽  
Hemodialysis Patients ◽  
Laser Doppler ◽  
Doppler Flowmetry ◽  
Skin Perfusion ◽  
Dorsal Area ◽  
Peripheral Arterial

Abstract Background A simpler method for detecting atherosclerosis obliterans is required in the clinical setting. Laser Doppler flowmetry (LDF) is easy to perform and can accurately detect deterioration in skin perfusion. We performed LDF for hemodialysis patients to determine the correlations between blood flow in the lower limbs and peripheral arterial disease (PAD). Methods This retrospective study included 128 hemodialysis patients. Patients were categorized into the non-PAD group (n = 106) and PAD group (n = 22), 14 early stage PAD patients were included in the PAD group. We conducted LDF for the plantar area and dorsal area of the foot and examined skin perfusion pressure (SPP) during dialysis. Results SPP-Dorsal Area values were 82.1 ± 22.0 mmHg in the non-PAD, and 59.1 ± 20.3 mmHg in PAD group, respectively (p < 0.05). The LDF-Plantar blood flow (Qb) values were 32.7 ± 15.5 mL/min in non-PAD group and 21.5 ± 11.3 mL/min in PAD group (p < 0.001). A total of 21 non-PAD patients underwent LDF before and during dialysis. The LDF-Plantar-Qb values were 36.5 ± 17.6 mL/min before dialysis and 29.6 ± 17.7 mL/min after dialysis (p < 0.05). We adjusted SPP and LDF for PAD using logistic regression, SPP-Dorsal-Area and LDF-P were significantly correlated with PAD (p < 0.05). The receiver-operating characteristic curve analysis indicated cut-off values of 20.0 mL/min for LDF-Plantar-Qb during dialysis. Conclusion LDF is a simple technique for sensitive detection of early-stage PAD. This assessment will help physicians identify early-stage PAD, including Fontaine stage II in clinical practice, thereby allowing prompt treatment.

Safety of 60-day l-arginine supplementation of patients with peripheral arterial disease of lower limbs

2015 ◽  
Vol 67 ◽  
pp. 16
Author(s):  
Natasza Balcer-Dymel ◽  
Katarzyna Korzeniowska ◽  
Artur Cieślewicz ◽  
Anna Jabłecka
Keyword(s):  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Lower Limbs ◽  
Peripheral Arterial ◽  
Arginine Supplementation

scholarly journals First-in-human Results of Ultrasound Velocimetry for Visualization of Blood Flow Patterns in Patients with Peripheral Arterial Disease

2019 ◽  
Vol 58 (6) ◽  
pp. e805-e806
Author(s):  
Stefan Engelhard ◽  
Majorie van Helvert ◽  
Jason Voorneveld ◽  
Johan Bosch ◽  
Erik Groot Jebbink ◽  
...  
Keyword(s):  
Blood Flow ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Flow Patterns ◽  
Peripheral Arterial ◽  
Blood Flow Patterns ◽  
Ultrasound Velocimetry

scholarly journals 755 The Influence of the Blood Flow Restricted Training on the Acute Angiogenic and Endothelial Response in Patients With Peripheral Arterial Disease

2020 ◽  
Vol 29 ◽  
pp. S376
Author(s):  
A. Wlodarczyk ◽  
A. Wachsmann-Maga ◽  
M. Schonborn ◽  
A. Trynkiewicz ◽  
J. Krezel ◽  
...  
Keyword(s):  
Blood Flow ◽  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Endothelial Response ◽  
Peripheral Arterial
Sign in / Sign up

Export Citation Format

Share Document