Safety of 60-day l-arginine supplementation of patients with peripheral arterial disease of lower limbs

Abstract Peripheral arterial disease (PAD) is characterized by obstruction in the lower limbs, mainly due to atherosclerosis. The prevalence of the pathology in people under 40 years of age is 6% and 15-20% in the population over 65 years old.(1,2) Approximately 50% of the affected persons are, at the time of examination, asymptomatic.(3) The most important risk factors associated with this condition are smoking, diabetes mellitus (DM), high cholesterol and high blood pressure (HBP). The current study shows that, regardless of the association of risk factors or pre-hospital treatment, these patients do not benefit from a certain type of treatment (drug or interventional), which corresponds to the existing data in the literature, which do not document the choice of type of treatment depending on the patient’s age or comorbidities.

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Pharmacological therapy in critically ill patients with peripheral and concomitant arteriopathy

ABOUTOPEN ◽

10.19156/abtpn.2018.0068 ◽

2018 ◽

Vol 4 (1) ◽

pp. 166-173

Author(s):

Nicola Troisi ◽

Antonio Trani ◽

Pierluigi Antonino Cappiello

Keyword(s):

Peripheral Arterial Disease ◽

Clinical Manifestations ◽

Arterial Disease ◽

Risk Profile ◽

Pharmacological Therapy ◽

Lower Limbs ◽

Limb Amputation ◽

Critical Ischemia ◽

Good Safety Profile ◽

Peripheral Arterial

Peripheral arterial disease is one of the most frequent clinical manifestations of atherosclerotic disease. The clinical picture of critical ischemia of the lower limbs is often burdened by high mortality and the risk of limb amputation. The direct and indirect prostanoids, and in particular iloprost and cilostazol, are effective in the medical treatment of peripheral arterial disease. We describe here five clinical cases in which iloprost and cilostazol have been successfully administered in arterial patients with various concomitant cardiovascular diseases, highlighting a good safety profile in relation to the cardiocascular risk profile (Cardiology).

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Intermittent Claudication in Physiotherapists’ Practice

BioMed Research International ◽

10.1155/2019/2470801 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10

Author(s):

Anna Spannbauer ◽

Maciej Chwała ◽

Tomasz Ridan ◽

Arkadiusz Berwecki ◽

Piotr Mika ◽

...

Keyword(s):

Peripheral Arterial Disease ◽

Intermittent Claudication ◽

Lower Limb ◽

Systemic Disease ◽

Significant Risk ◽

Arterial Disease ◽

Lower Limbs ◽

Lower Limb Muscles ◽

Limb Muscles ◽

Peripheral Arterial

Intermittent claudication is a symptom of atherosclerosis of the lower limbs (peripheral arterial disease (PAD)) and is characterized by pain and cramps of lower limb muscles during exercise. Claudication leads to a reduction in physical activity of patients. PAD is a systemic disease. Atherosclerotic lesions located in the arteries of the lower limbs not only pose the risk of the ischemic limb loss, but above all, they are an important prognostic factor. Patients with claudication are at significant risk of cardiovascular complications such as infarcts or strokes. Comprehensive rehabilitation of patients with intermittent claudication based on the current TASC II (Inter-Society Consensus for the Management of Peripheral Arterial Disease) guidelines, ESC (European Society of Cardiology) guidelines, and AHA (American Heart Association) guidelines includes supervised treadmill training, training on a bicycle ergometer, Nordic Walking, resistance exercises of lower limb muscles, and exercises of upper limbs. A trained, educated, and motivated patient has a chance to improve life quality as well as life expectancy.

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