8 Application of polymer membranes in downstream processes

2021 ◽  
pp. 155-164
Author(s):  
Katalin Belafi-Bako ◽  
Gabor Toth ◽  
Nandor Nemestothy
Keyword(s):  
Polymer Membranes ◽  
Downstream Processes

Application of polymer membranes in downstream processes

2020 ◽  
Vol 5 (7) ◽  
Author(s):  
Katalin Belafi-Bako ◽  
Gabor Toth ◽  
Nandor Nemestothy
Keyword(s):  
Polymer Membranes ◽  
Downstream Processing ◽  
Membrane Processes ◽  
Downstream Processes ◽  
Fermentation Technology ◽  
Pressure Driven

AbstractThe purpose of downstream processing in a fermentation technology is the isolation, purification and concentration of the final product. Membrane processes are generally used in these steps. In this paper, the application possibilities of polymer membranes in pressure-driven membrane techniques (microfiltration, ultrafiltration, nanofiltration), pervaporation, dialysis and electrodialysis are presented.

Use of vent stack temperature as a feedforward variable for dissolver total titratable alkali (TTA) control

TAPPI Journal ◽  
2018 ◽  
Vol 17 (05) ◽  
pp. 261-269
Author(s):  
Wei Ren ◽  
Brennan Dubord ◽  
Jason Johnson ◽  
Bruce Allison
Keyword(s):  
Feedback Control ◽  
Current Practice ◽  
Feedforward Control ◽  
Control Variable ◽  
Indirect Measurement ◽  
Tight Control ◽  
Transfer Lines ◽  
Green Liquor ◽  
Process Dynamics ◽  
Downstream Processes

Tight control of raw green liquor total titratable alkali (TTA) may be considered an important first step towards improving the overall economic performance of the causticizing process. Dissolving tank control is made difficult by the fact that the unknown smelt flow is highly variable and subject to runoff. High TTA variability negatively impacts operational costs through increased scaling in the dissolver and transfer lines, increased deadload in the liquor cycle, under- and over-liming, increased energy consumption, and increased maintenance. Current practice is to use feedback control to regulate the TTA to a target value through manipulation of weak wash flow while simultaneously keeping dissolver density within acceptable limits. Unfortunately, the amount of variability reduction that can be achieved by feedback control alone is fundamentally limited by the process dynamics. One way to improve upon the situation would be to measure the smelt flow and use it as a feedforward control variable. Direct measurement of smelt flow is not yet possible. The use of an indirect measurement, the dissolver vent stack temperature, is investigated in this paper as a surrogate feedforward variable for dissolving tank TTA control. Mill trials indicate that significant variability reduction in the raw green liquor TTA is possible and that the control improvements carry through to the downstream processes.

BIOCOMPATIBILITY OF BIODEGRADATED POLYMER MEMBRANES BASED ON POLYGLYCOLIDLACTIDE OF VARIOUS MOLECULAR MASS

2018 ◽  
Author(s):  
A.S. Baikin ◽  
◽  
M. A. Sevostyanov ◽  
E.O. Nasakina ◽  
K.V. Sergienko ◽  
...  
Keyword(s):  
Molecular Mass ◽  
Polymer Membranes

Protein Solvent Interaction: Transition of Protein-solvent Interaction Concept from Basic Research into Solvent Manipulation of Chromatography

2018 ◽  
Vol 20 (1) ◽  
pp. 34-39 ◽  
Author(s):  
Tsutomu Arakawa ◽  
Yoshiko Kita
Keyword(s):  
Column Chromatography ◽  
Rapid Development ◽  
Academic Research ◽  
Basic Research ◽  
Protein Stabilization ◽  
Special Issue ◽  
Solvent Interaction ◽  
Protein Formulations ◽  
Solvent Additive ◽  
Downstream Processes

Previously, we have reviewed in this journal (Arakawa, T., Kita, Y., Curr. Protein Pept. Sci., 15, 608-620, 2014) the interaction of arginine with proteins and various applications of this solvent additive in the area of protein formulations and downstream processes. In this special issue, we expand the concept of protein-solvent interaction into the analysis of the effects of solvent additives on various column chromatography, including mixed-mode chromatography. Earlier in our research, we have studied the interactions of such a variety of solvent additives as sugars, salts, amino acids, polymers and organic solvents with a variety of proteins, which resulted in mechanistic understanding on their protein stabilization and precipitation effects, the latter known as Hofmeister series. While such a study was then a pure academic research, rapid development of genetic engineering technologies and resultant biotechnologies made it a valuable knowledge in fully utilizing solvent additives in manipulation of protein solution, including column chromatography.

Electrically switchable polymer membranes with photo-aligned nematic structures for photonic applications

2020 ◽  
Vol 109 ◽  
pp. 110296
Author(s):  
Alexander V. Dubtsov ◽  
Saša Harkai ◽  
Dina V. Shmeliova ◽  
Sergey V. Pasechnik ◽  
Robert Repnik ◽  
...  
Keyword(s):  
Polymer Membranes

Strategy to equivalence testing for development and scale up of biopharmaceutical downstream processes

2021 ◽  
Vol 235 ◽  
pp. 116497
Author(s):  
Christina Yassouridis ◽  
Astrid Dürauer ◽  
Theresa Scharl ◽  
Friedrich Leisch ◽  
Cécile Brocard ◽  
...  
Keyword(s):  
Scale Up ◽  
Equivalence Testing ◽  
Downstream Processes

Microchip Dialysis of Proteins Using in Situ Photopatterned Nanoporous Polymer Membranes

2004 ◽  
Vol 76 (8) ◽  
pp. 2367-2373 ◽  
Author(s):  
Simon Song ◽  
Anup K. Singh ◽  
Timothy J. Shepodd ◽  
Brian J. Kirby
Keyword(s):  
Polymer Membranes

Fast Water Transport Through Sub-5 nm Polyamide Nanofilms: The New Upper-Bound of the Permeance-Selectivity Trade-Off in Nanofiltration

2021 ◽  
Author(s):  
Pulak Sarkar ◽  
Solagna Modak ◽  
Santanu Ray ◽  
Vasista Adupa ◽  
K. Anki Reddy ◽  
...  
Keyword(s):  
Water Transport ◽  
Composite Membrane ◽  
Upper Bound ◽  
Polymer Membranes ◽  
Liquid Transport ◽  
Trade Off ◽  
Commercial Exploitation

Liquid transport through the composite membrane is inversely proportional to the thickness of its separation layer. While the scalable fabrication of ultrathin polymer membranes is sought for their commercial exploitation,...

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