Evaluation of a new generation of plastic evacuated blood-collection tubes in clinical chemistry, therapeutic drug monitoring, hormone and trace metal analysis

AbstractPolyethylene terephthalate (PET) tubes have several advantages over glass tubes: they are unbreakable, lighter and more easily disposed of. Despite a steady increase in their use and an expansion of the range of available tubes, few studies validating their use have been published in the literature. This paper describes the various studies that have been performed to compare VENOJECT glass, VENOSAFE PET and VENOSAFE PET/heparin tubes for the assay of a panel of analytes in routine clinical chemistry, immunochemistry, hormone and tumor marker analysis and trace metal determination. These studies demonstrate that VENOSAFE PET tubes are a suitable alternative to glass tubes.

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Trace Metal Analysis in Clinical Chemistry

Progress in Analytical Chemistry ◽

10.1007/978-1-4684-3324-1_2 ◽

1976 ◽

pp. 15-28 ◽

Cited By ~ 1

Author(s):

Douglas G. Mitchell

Keyword(s):

Trace Metal ◽

Clinical Chemistry ◽

Metal Analysis ◽

Trace Metal Analysis

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Trace Metal Analysis and Quality Assurance in Clinical Chemistry

Biological Trace Element Research - ACS Symposium Series ◽

10.1021/bk-1991-0445.ch009 ◽

1991 ◽

pp. 113-119

Author(s):

J. Savory ◽

M. G. Savory ◽

M. R. Wills

Keyword(s):

Quality Assurance ◽

Trace Metal ◽

Clinical Chemistry ◽

Metal Analysis ◽

Trace Metal Analysis

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TRACE METAL ANALYSIS IN LONG ISLAND MARSH CORES

10.1130/abs/2020se-345411 ◽

2020 ◽

Author(s):

Moread Achek ◽

◽

E. Christa Farmer ◽

Brandon Buchbinder ◽

Joyce Bowen ◽

...

Keyword(s):

Trace Metal ◽

Long Island ◽

Metal Analysis ◽

Trace Metal Analysis

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Clinical Evaluation of the Torq Zero Delay Centrifuge System for Decentralized Blood Collection and Stabilization

Diagnostics ◽

10.3390/diagnostics11061019 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1019

Author(s):

Kyungjin Hong ◽

Gabriella Iacovetti ◽

Ali Rahimian ◽

Sean Hong ◽

Jon Epperson ◽

...

Keyword(s):

Clinical Chemistry ◽

Blood Collection ◽

Test Results ◽

Sample Collection ◽

Rapid Separation ◽

Cell Counts ◽

Collection Device ◽

Precision Study ◽

Clinically Significant ◽

Blood Specimens

Blood sample collection and rapid separation—critical preanalytical steps in clinical chemistry—can be challenging in decentralized collection settings. To address this gap, the Torq™ zero delay centrifuge system includes a lightweight, hand-portable centrifuge (ZDrive™) and a disc-shaped blood collection device (ZDisc™) enabling immediate sample centrifugation at the point of collection. Here, we report results from clinical validation studies comparing performance of the Torq System with a conventional plasma separation tube (PST). Blood specimens from 134 subjects were collected and processed across three independent sites to compare ZDisc and PST performance in the assessment of 14 analytes (K, Na, Cl, Ca, BUN, creatinine, AST, ALT, ALP, total bilirubin, albumin, total protein, cholesterol, and triglycerides). A 31-subject precision study was performed to evaluate reproducibility of plasma test results from ZDiscs, and plasma quality was assessed by measuring hemolysis and blood cells from 10 subject specimens. The ZDisc successfully collected and processed samples from 134 subjects. ZDisc results agreed with reference PSTs for all 14 analytes with mean % biases well below clinically significant levels. Results were reproducible across different operators and ZDisc production lots, and plasma blood cell counts and hemolysis levels fell well below clinical acceptance thresholds. ZDiscs produce plasma samples equivalent to reference PSTs. Results support the suitability of the Torq System for remotely collecting and processing blood samples in decentralized settings.

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