Electrochemical determination of atenolol and propranolol using a carbon paste sensor modified with natural ilmenite

Abstract In this study, a simple voltammetric method was reported for independent determination of propranolol (PROP) and atenolol (ATN) in pharmaceutical tablets using carbon paste electrode modified with natural Ilmenite (CPE-I). The analytical performance of the modified sensor was evaluated using the square wave voltammetry and cyclic voltammetry for determination of both β(beta) blockers in 0.1 mol L−1 of sulfuric acid solution (H2SO4). The signal obtained with modified carbon paste electrode in 0.1 mol L−1 of H2SO4 showed a good electrocatalytic activity toward the oxidations of PROP and ATN compared with the bare one. The enhanced oxidation peak current response can be attributed to the catalytic effect of the ilmenite nanomaterial incorporated into the carbon paste electrode. Under optimal condition, good linear calibration curves were obtained ranging from 0.20 to 8.9 mmol L−1 for PROP and 2.0 to 9.9 µmol L−1 for ATN, with detection limits of 80 and 0.31 µmol L−1, respectively. The CPE-I sensor had good repeatability and reproducibility (RSD ≤ 3.2%) and high sensitivity for the detection of both ATN and PROP. The proposed sensor was applied for detection of these drugs in pharmaceutical tablets. The obtained results indicate that the voltammetric CPE-I sensor could be an alternative method for the routine quality control of the β blockers in complex matrices.

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Electrochemical Determination of Dopamine and Uric Acid Using Poly(proline) Modified Carbon Paste Electrode: A Cyclic Voltammetric Study

Chemistry & Chemical Technology ◽

10.23939/chcht15.02.153 ◽

2021 ◽

Vol 15 (2) ◽

pp. 153-160

Author(s):

Edwin S. D’ Souza ◽

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Jamballi G. Manjunatha ◽

Chenthattil Raril ◽

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...

Keyword(s):

Uric Acid ◽

Modified Electrode ◽

Carbon Paste Electrode ◽

Oxidation Potential ◽

Modified Carbon Paste Electrode ◽

Current Response ◽

Carbon Paste ◽

Cyclic Voltammetric ◽

Paste Electrode

A cyclic voltammetric technique was used for electropolymerisation of proline on the surface of carbon paste electrode and for individual and concurrent determination of dopamine (DA) and uric acid (UA). The surface morphology of the developed electrode was studied by using field emission scanning electron microscopy. The modified electrode showed a high current response towards DA as compared to the bare electrode. The developed modified electrode shows good catalytic activity with a different oxidation potential of DA and UA. The electrode process was found to be adsorption controlled. The developed method shows very good stability and reproducibility. Under the optimized conditions, the concentration range is (1‒2)∙10-4 M and the observed detection limit was 4.7∙10-6 M. The developed sensor was applied for the determination of DA in the real sample with a good recovery.

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Electroanalytical Performance of a Carbon Paste Electrode Modified by Coffee Husks for the Quantification of Acetaminophen in Quality Control of Commercialized Pharmaceutical Tablets

International Journal of Electrochemistry ◽

10.1155/2016/1953278 ◽

2016 ◽

Vol 2016 ◽

pp. 1-10 ◽

Cited By ~ 9

Author(s):

Serge Foukmeniok Mbokou ◽

Maxime Pontié ◽

Jean-Philippe Bouchara ◽

Francis Merlin Melataguia Tchieno ◽

Evangeline Njanja ◽

...

Keyword(s):

Carbon Paste Electrode ◽

Low Cost ◽

Pharmaceutical Formulations ◽

Differential Pulse ◽

Electrochemical Determination ◽

Current Response ◽

Carbon Paste ◽

Pharmaceutical Tablets ◽

Paste Electrode

Electrochemical determination of acetaminophen (APAP) was successfully performed using a carbon paste electrode (CPE) modified with coffee husks (CH-CPE). Scanning electron microscopy (SEM) and SEM-energy dispersive X-ray spectroscopy (SEM-EDX) were, respectively, used for the morphological and elemental characterization of coffee husks prior to their utilization. The electrochemical oxidation of APAP was investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV). SWV technique appeared to be more sensitive since the oxidation current of APAP was twofold higher with the CH-CPE sensor than with the bare CPE, in relation to the increase in the organophilic character of the electrode surface. Furthermore, on CH-CPE, the current response of APAP varied linearly with its concentration in the range of 6.6 μM to 0.5 mM, leading to a detection limit of 0.66 μM (S/N=3). Finally, the proposed CH-CPE sensor was successfully used to determine the amount of APAP in commercialized tablets (Doliprane® 500 and Doliprane 1000), with a recovery rate ranging from 98% to 103%. This novel sensor opens the way for the development of low-cost and reliable devices for the electroanalysis of pharmaceutical formulations in developing countries.

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Electrochemical Behaviour of Tinidazole at 1,4-Benzoquinone Modified Carbon Paste Electrode and Its Direct Determination in Pharmaceutical Tablets and Urine by Differential Pulse Voltammetry

Journal of Analytical Methods in Chemistry ◽

10.1155/2017/8518707 ◽

2017 ◽

Vol 2017 ◽

pp. 1-10 ◽

Cited By ~ 1

Author(s):

Yosef Nikodimos ◽

Beyene Hagos

Keyword(s):

Carbon Paste Electrode ◽

Limit Of Detection ◽

Direct Determination ◽

Differential Pulse ◽

Modified Carbon Paste Electrode ◽

Reduction Peak ◽

Current Response ◽

Carbon Paste ◽

Paste Electrode

A simple and highly sensitive electrochemical method based on a 1,4-benzoquinone modified carbon paste electrode (1,4-BQMCPE) was described for the determination of tinidazole (TDZ). In Britton Robinson buffer solution, TDZ yields well-defined irreversible reduction peak at −0.344 V on a 1,4-BQMCPE. Compared with that on a bare CPE, the reduction peak of TDZ increased significantly on the modified CPE and the effects of different parameters on the voltammetric responses were also investigated. Differential pulse voltammetric method was proposed and optimized for TDZ determination and its reductive peak current response at 1,4-BQMCPE was found to show linear dependence on the concentration of TDZ in the range of 1.0 × 10−6 to 5.0 × 10−4 M with a linear regression equation, correlation coefficient, limit of detection (LOD), and limit of quantification (LOQ) of IPC (μA) = 0.19958 + 0.02657C (μM), 0.99486, 1.10 × 10−7 M, and 3.77 × 10−7, respectively. Excellent recovery results for spiked TDZ in pharmaceutical tablet samples ranging within 97.44–97.51% and in urine ranging within 95.37–96.91% were observed. The selectivity of the method for TDZ was further studied in the presence of selected potential interferents and confirmed the potential applicability of the developed method for the determination of TDZ.

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