scholarly journals Stimuli-responsive DOX release behavior of cross-linked poly(acrylic acid) nanoparticles

e-Polymers ◽  
2019 ◽  
Vol 19 (1) ◽  
pp. 203-214 ◽  
Author(s):  
Goolia Nikravan ◽  
Vahid Haddadi-Asl ◽  
Mehdi Salami-Kalajahi
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Cancer Drug ◽  
Cross Linking ◽  
Burst Release ◽  
Release Behavior ◽  
Molar Ratios ◽  
Distillation Precipitation Polymerization ◽  
Kinetics Of ◽  
Poly Acrylic Acid

AbstractCross-linked poly(acrylic acid) nanoparticles were synthesized via distillation precipitation polymerization of acrylic acid and ethylene glycol dimethacrylate withdifferent molar ratios. Spherical nanoparticles with diameters between 75 and 122 nm were synthesized and exhibited temperature and pH-responsive behaviors. However, this behavior was less pronounced for samples with higher cross-linking degrees. The potential of all nanoparticles as carriers for controlled release of doxorubicin (DOX) anti-cancer drug was examined at pH values of 1.2, 5.3 and 7.4. An obvious alleviation in burst release behavior and the amount of cumulative drug release was seen for all nanoparticles as the pH of the medium and the cross-linking degree of nanoparticle increased. Also kinetics of drug release was studied using mathematical models of zero-order, first-order, Higuchi, Korsmeyer-Peppas and Hixson-Crowell, where Higuchi and Korsmeyer-Peppas models best defined the kinetics of drug release.

Effect of Hydroxyapatite Nanoparticles on Ibuprofen Release from Carboxymethyl-Hexanoyl Chitosan/O-Hexanoyl Chitosan Hydrogel

2006 ◽  
Vol 6 (9) ◽  
pp. 2929-2935 ◽  
Author(s):  
Tse-Ying Liu ◽  
Ting-Yu Liu ◽  
San-Yuan Chen ◽  
Shian-Chuan Chen ◽  
Dean-Mo Liu
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Burst Release ◽  
Release Behavior ◽  
Chitosan Hydrogel ◽  
Sequential Release ◽  
Water Accessibility ◽  
Hydrophilic Nature ◽  
Hexanoyl Chitosan ◽  
Kinetics Of

In order to explore the effect of nanofiller on the regulation of the drug release behavior from microsphere-embedded hydrogel prepared by carboxymethyl-hexanoyl chitosan (HNOCC) and O-hexanoyl chitosan (OHC), the release kinetics was investigated in terms of various amounts of calcium-deficient hydroxyapatite (CDHA) nanoparticles incorporated. HNOCC is a novel chitosan-based hydrophilic matrix with a burst release profile in a highly swollen state. The drug release kinetics of the HNOCC hydrogel can be regulated by incorporation of well-dispersed CDHA nanoparticles. It was found that the release duration of ibuprofen (IBU) from HNOCC was prolonged with increasing amounts of CDHA which acts as a crosslink agent and diffusion barrier. On the contrary, the release duration of the IBU from OHC (hydrophobic phase) was shortened through increasing the CDHA amount over 5%, which is due to the hydrophilic nature of the CDHA nanoparticles destroying the intermolecular hydrophobic interaction and accelerating OHC degradation. Thus, water accessibility and molecular relaxation were enhanced, resulting in a higher release rate. In addition, sustained and sequential release behavior was achieved by embedding the OHC microspheres (hydrophobic phase) into the HNOCC (hydrophilic phase) matrix, which could significantly prolong the release duration of the HNOCC drug-loaded implant.

Enhanced drug release by selective cleavage of cross-links in a double-cross-linked hydrogel

RSC Advances ◽  
2016 ◽  
Vol 6 (104) ◽  
pp. 102453-102461 ◽  
Author(s):  
Neha Tiwari ◽  
Manohar V. Badiger
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Cross Linking ◽  
Cross Links ◽  
Double Cross ◽  
Poly Acrylic Acid

Poly(acrylic acid) hydrogels were synthesized using two different cross-linking agents namely, cystamine and Jeffamine. The redox sensitive di-sulfide linkages could be selectively cleaved to enhance the release of doxorubicin.

scholarly journals Drug Release OFF Behavior and Deswelling Kinetics of Thermo-Responsive IPNs Composed of Poly(acrylamide-co-butyl methacrylate) and Poly(acrylic acid)

1991 ◽  
Vol 23 (10) ◽  
pp. 1179-1189 ◽  
Author(s):  
Hiroki Katono ◽  
Kohei Sanui ◽  
Naoya Ogata ◽  
Teruo Okano ◽  
Yasuhisa Sakurai
Keyword(s):  
Drug Release ◽  
Acrylic Acid ◽  
Butyl Methacrylate ◽  
Kinetics Of ◽  
Poly Acrylamide ◽  
Poly Acrylic Acid

Fabrication of Sustained Release System of Electrospun Poly(acrylic acid)/Dextran Nanofibers Using Emulsion Electrospinning as Wound Dressing Applications

2021 ◽  
Vol 21 (3) ◽  
pp. 1613-1622
Author(s):  
A. Meera Moydeen ◽  
Badr M. Thamer ◽  
Ali Aldalbahi ◽  
Hany El-Hamshary ◽  
Abdullah M. Al-Enizi ◽  
...  
Keyword(s):  
Electron Microscope ◽  
Acrylic Acid ◽  
Sustained Release ◽  
Wound Dressing ◽  
Confocal Laser ◽  
Release Mechanism ◽  
Core Shell ◽  
Burst Release ◽  
Release Behavior ◽  
Poly Acrylic Acid

The burst release of drug is a problem associated with the use of common blending electrospinning. This problem can be avoided via fabrication of core–shell nanofibers where drug can be coated with polymer nanofibers as a shell. Moreover, there is a need to provide wound dressing with prolonged system of sustained release to accelerate the recovery of the wound. Currently, electrospun ciprofloxacin loaded poly(acrylic acid)/Dextran (Cipro@PAA/Dex) core–shell nanofibers can be prepared in green method using emulsion electrospinning. For comparison study, blend electrospun nanofibers (Cipro/PAA/Dex) was also prepared. The entrapment of drug into the polymeric material and the interaction between polymer blends were confirmed by FT-IR. Moreover, DSC was used to identify the type of interaction between polymeric chains. Field emission scanning electron microscope (FE-SEM) was used to study the nanofiber morphology and transmission electron microscope (TEM) and confocal laser scanning microscope (CLSM) were used to confirm the formation of core–shell structure. In vitro drug release profile was monitored by UV-Vis spectrophotometer and the results showed that Cipro@PAA/Dex exhibited controlled release behavior whereas Cipro/PAA/Dex showed burst release behavior. Moreover, the release mechanism is kinetically followed diffusion.

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