Preparation and characterization of electrospun fibrous scaffolds of either PVA or PVP for fast release of sildenafil citrate

AbstractSildenafil citrate (SC) has proved to be an effective and inexpensive drug for the treatment of pulmonary arterial hypertension (PAH). This study aims to synthesize electrospun, submicron fiber scaffolds of poly(vinyl alcohol) (PVA) and poly(vinyl pyrrolidone) (PVP) loaded with SC for fast drug dissolution and its potential use in the treatment of PAH. These fiber scaffolds were prepared through the electrospinning technique. The chemical composition of the nanofibers was analyzed by Fourier transform infrared spectroscopy. Thermal stability was studied by thermogravimetric analysis and polymeric transitions by differential scattering calorimetry. Surface analysis of the nanofibers was studied by field emission scanning electron microscopy. The wetting and dissolution time of the scaffolds and drug release rate were studied as well. The drug-loaded PVP fibers showed better quality regarding size and homogeneity compared to drug-loaded PVA fibers. These fibers encapsulated approximately 2.5 mg/cm2 of the drug and achieved immediate controlled released rate, which is encouraging for further studies leading to an alternative treatment of PAH in children.

Download Full-text

Characterization of polymeric biocomposite based on poly(vinyl alcohol) and poly(vinyl pyrrolidone)

Polymer Composites ◽

10.1002/pc.20197 ◽

2006 ◽

Vol 27 (2) ◽

pp. 147-152 ◽

Cited By ~ 26

Author(s):

Vladimír Sedlařík ◽

Nabanita Saha ◽

Ivo Kuřitka ◽

Petr Sáha

Keyword(s):

Vinyl Alcohol ◽

Vinyl Pyrrolidone ◽

Poly Vinyl Alcohol ◽

Poly Vinyl Pyrrolidone

Download Full-text

Characterization of associating hydrogels of poly(vinyl alcohol) and poly(vinyl pyrrolidone)

Journal of Applied Polymer Science ◽

10.1002/app.29359 ◽

2009 ◽

Vol 112 (1) ◽

pp. 541-549 ◽

Cited By ~ 11

Author(s):

X. Liu ◽

G. Fussell ◽

M. Marcolongo ◽

A. M. Lowman

Keyword(s):

Vinyl Alcohol ◽

Vinyl Pyrrolidone ◽

Poly Vinyl Alcohol ◽

Poly Vinyl Pyrrolidone

Download Full-text

Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs

Pharmaceutics ◽

10.3390/pharmaceutics11080417 ◽

2019 ◽

Vol 11 (8) ◽

pp. 417 ◽

Cited By ~ 12

Author(s):

Emese Sipos ◽

Nóra Kósa ◽

Adrienn Kazsoki ◽

Zoltán-István Szabó ◽

Romána Zelkó

Keyword(s):

Oral Absorption ◽

Vinyl Pyrrolidone ◽

Drug Dissolution ◽

In Vitro Dissolution ◽

Drug Release Profile ◽

Scanning Calorimetry ◽

Ft Ir ◽

Fast Dissolution ◽

Poly Vinyl Pyrrolidone

Aceclofenac-loaded poly(vinyl-pyrrolidone)-based nanofiber formulations were prepared by electrospinning to obtain drug-loaded orally disintegrating webs to enhance the solubility and dissolution rate of the poorly soluble anti-inflammatory active that belongs to the BCS Class-II. Triethanolamine-containing ternary composite of aceclofenac-poly(vinyl-pyrrolidone) nanofibers were formulated to exert the synergistic effect on the drug-dissolution improvement. The composition and the electrospinning parameters were changed to select the fibrous sample of optimum fiber characteristics. To determine the morphology of the nanofibers, scanning electron microscopy was used. Fourier transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC) were applied for the solid-state characterization of the samples, while the drug release profile was followed by the in vitro dissolution test. The nanofibrous formulations had diameters in the range of few hundred nanometers. FT-IR spectra and DSC thermograms indicated the amorphization of aceclofenac, which resulted in a rapid release of the active substance. The characteristics of the selected ternary fiber composition (10 mg/g aceclofenac, 1% w/w triethanolamine, 15% w/w PVPK90) were found to be suitable for obtaining orally dissolving webs of fast dissolution and potential oral absorption.

Download Full-text