SYNTHESIS AND SPECTRAL STUDIES OF NITROSOUREA DERIVATIVES OF 6-BROMO AND 6-CHLORO-2,3-DIHYDRO-1,4-BENZOTHIAZINES AS POSSIBLE ANTICANCER AGENTS

1996 ◽  
Vol 2 (6) ◽  
Author(s):  
Dinesh Rai ◽  
Vandana Gupta ◽  
R.R. Gupta
Keyword(s):  
Anticancer Agents ◽  
Spectral Studies ◽  
Derivatives Of

Hybridized Quinoline Derivatives as Anticancer Agents: Design, Synthesis, Biological Evaluation and Molecular Docking

2019 ◽  
Vol 19 (4) ◽  
pp. 439-452 ◽  
Author(s):  
Mohamed R. Selim ◽  
Medhat A. Zahran ◽  
Amany Belal ◽  
Moustafa S. Abusaif ◽  
Said A. Shedid ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Anticancer Agents ◽  
Caspase 3 ◽  
Biological Evaluation ◽  
Tubulin Polymerization ◽  
Design Synthesis ◽  
Chemical Structures ◽  
M Phase ◽  
Induced Apoptosis ◽  
Derivatives Of

Objective: Conjugating quinolones with different bioactive pharmacophores to obtain potent anticancer active agents. Methods: Fused pyrazolopyrimidoquinolines 3a-d, Schiff bases 5, 6a-e, two hybridized systems: pyrazolochromenquinoline 7 and pyrazolothiazolidinquinoline 8, different substituted thiazoloquinolines 13-15 and thiazolo[3,2-a]pyridine derivatives 16a-c were synthesized. Their chemical structures were characterized through spectral and elemental analysis, cytotoxic activity on five cancer cell lines, caspase-3 activation, tubulin polymerization inhibition and cell cycle analysis were evaluated. Results: Four compounds 3b, 3d, 8 and 13 showed potent activity than doxorubicin on HCT116 and three compounds 3b, 3d and 8 on HEPG2. These promising derivatives showed increase in the level of caspase-3. The trifloromethylphenyl derivatives of pyrazolopyrimidoquinolines 3b and 3d showed considerable tubulin polymerization inhibitory activity. Both compounds arrested cell cycle at G2/M phase and induced apoptosis. Conclusion: Compounds 3b and 3d can be considered as promising anticancer active agents with 70% of colchicine activity on tubulin polymerization inhibition and represent hopeful leads that deserve further investigation and optimization.

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

Synthetis of Potential Anticancer Agents. XVI. S-Substituted Derivatives of 6-Mercaptopurine1a

1958 ◽  
Vol 80 (23) ◽  
pp. 6265-6271 ◽  
Author(s):  
Thomas P. Johnston ◽  
Lee B. Holum ◽  
John A. Montgomery
Keyword(s):  
Anticancer Agents ◽  
Derivatives Of

Hydrogen bonds in derivatives of N-substituted N’-benzoyl- and N’-(2-chlorobenzoyl)thiourea

1991 ◽  
Vol 56 (4) ◽  
pp. 880-885 ◽  
Author(s):  
Oľga Hritzová ◽  
Dušan Koščík
Keyword(s):  
Hydrogen Bonds ◽  
Spectral Studies ◽  
Intramolecular Hydrogen Bonds ◽  
Tautomeric Forms ◽  
Intramolecular Hydrogen ◽  
Derivatives Of

Intramolecular hydrogen bonds of the N-H···O=C type have been detected in the derivatives of N-substituted N’-benzoyl- and N’-(2-chlorobenzoyl)thiourea on the basis of IR spectral studies. The title compounds can exist in two tautomeric forms.

New derivatives of imidazole as potential anticancer agents

Il Farmaco ◽  
1998 ◽  
Vol 53 (5) ◽  
pp. 342-345 ◽  
Author(s):  
Izabella Krȩżel
Keyword(s):  
Anticancer Agents ◽  
Derivatives Of

Chemoselective synthesis and spectral studies of N-thiocyanatoacetyl derivatives of 3-alkyl-2,6-diarylpiperidin-4-ones

2016 ◽  
Vol 191 (9) ◽  
pp. 1209-1215 ◽  
Author(s):  
M. Velayutham Pillai ◽  
K. Rajeswari ◽  
C. Udhaya Kumar ◽  
C. Ramalingan ◽  
A. Manohar ◽  
...  
Keyword(s):  
Spectral Studies ◽  
Chemoselective Synthesis ◽  
Derivatives Of
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