Sildenafil protects human mammary epithelial cells against ROS production induced by estradiol

2011 ◽  
Vol 6 (3) ◽  
Author(s):  
Gennaro Taibi ◽  
Letizia Cocciadiferro ◽  
Vitale Miceli ◽  
Giuseppe Carruba ◽  
Concetta M.A. Nicotra
Keyword(s):  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Xanthine Dehydrogenase ◽  
Mammary Epithelial ◽  
Enos Gene ◽  
Ros Production ◽  
Aortic Endothelial Cells ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial ◽  
Expression And Activity

AbstractSeveral studies suggest that xanthine dehydrogenase (XDH) and its oxidase form (XO) play an important role in various types of ischemic and vascular injuries. Recently, we have demonstrated that estradiol (E2) induces a significant decrease of the expression and activity of XDH and of its conversion to XO in human mammary epithelial cells. E2 is known to induce upregulation of eNOS gene expression in aortic endothelial cells. Because the XO-derived O

scholarly journals Viral oncogenes accelerate conversion to immortality of cultured conditionally immortal human mammary epithelial cells

Oncogene ◽  
1999 ◽  
Vol 18 (13) ◽  
pp. 2169-2180 ◽  
Author(s):  
James Garbe ◽  
Michelle Wong ◽  
Don Wigington ◽  
Paul Yaswen ◽  
Martha R Stampfer
Keyword(s):  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Human Mammary Epithelial Cells ◽  
Viral Oncogenes ◽  
Human Mammary Epithelial
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