Xanthine dehydrogenase processes retinol to retinoic acid in human mammary epithelial cells

2008 ◽  
Vol 23 (3) ◽  
pp. 317-327 ◽  
Author(s):  
Gennaro Taibi ◽  
Francesca Di Gaudio ◽  
Concetta M. A. Nicotra
Keyword(s):  
Retinoic Acid ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Xanthine Dehydrogenase ◽  
Mammary Epithelial ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial

Sildenafil protects human mammary epithelial cells against ROS production induced by estradiol

2011 ◽  
Vol 6 (3) ◽  
Author(s):  
Gennaro Taibi ◽  
Letizia Cocciadiferro ◽  
Vitale Miceli ◽  
Giuseppe Carruba ◽  
Concetta M.A. Nicotra
Keyword(s):  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Xanthine Dehydrogenase ◽  
Mammary Epithelial ◽  
Enos Gene ◽  
Ros Production ◽  
Aortic Endothelial Cells ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial ◽  
Expression And Activity

AbstractSeveral studies suggest that xanthine dehydrogenase (XDH) and its oxidase form (XO) play an important role in various types of ischemic and vascular injuries. Recently, we have demonstrated that estradiol (E2) induces a significant decrease of the expression and activity of XDH and of its conversion to XO in human mammary epithelial cells. E2 is known to induce upregulation of eNOS gene expression in aortic endothelial cells. Because the XO-derived O

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